Liver transplantation(LT)represents a life-saving surgical procedure and is considered the current standard of care for the majority of patients having end-stage liver disease.As known,significant progress in organ pr...Liver transplantation(LT)represents a life-saving surgical procedure and is considered the current standard of care for the majority of patients having end-stage liver disease.As known,significant progress in organ preservation techniques,perioperative care,and strict immunosuppression protocols are associated with favorable patient/graft survival post-LT.Hence,proper evaluation of liver allograft-related complications among survivors has paid great attention,particularly the rejection sequel after LT.It is a seriously underestimated cause of allograft injury,which pushes researchers for understanding the exact pathogenesis of different types and proper time diagnosis for better management of such complications.However,it still represents a challenge because of the complexities related to diagnosis and histopathology.Hence,increasing clinical awareness with earlier diagnosis of post-LT rejection is essential through stimulating further studies.Therefore,our review will focus on the clinicopathological debates regarding liver allograft loss after transplantation.展开更多
文摘Liver transplantation(LT)represents a life-saving surgical procedure and is considered the current standard of care for the majority of patients having end-stage liver disease.As known,significant progress in organ preservation techniques,perioperative care,and strict immunosuppression protocols are associated with favorable patient/graft survival post-LT.Hence,proper evaluation of liver allograft-related complications among survivors has paid great attention,particularly the rejection sequel after LT.It is a seriously underestimated cause of allograft injury,which pushes researchers for understanding the exact pathogenesis of different types and proper time diagnosis for better management of such complications.However,it still represents a challenge because of the complexities related to diagnosis and histopathology.Hence,increasing clinical awareness with earlier diagnosis of post-LT rejection is essential through stimulating further studies.Therefore,our review will focus on the clinicopathological debates regarding liver allograft loss after transplantation.
