BACKGROUND Radical resection of gastric cancer liver metastases(GCLM)can increase the 5-year survival rate of GCLM patients.However,patients may lose the theoretical feasibility of surgery due to the critical location...BACKGROUND Radical resection of gastric cancer liver metastases(GCLM)can increase the 5-year survival rate of GCLM patients.However,patients may lose the theoretical feasibility of surgery due to the critical location of liver metastasis in some cases.CASE SUMMARY A 29-year-old woman had a chief complaint of chronic abdominal pain for 1 year.Abdominal computed tomography and magnetic resonance imaging examinations suggested a mass of unknown pathological nature located between the first and second hila and the margin of the lower segment of the right lobe of the liver.The anterior wall of the gastric antrum was unevenly thickened.The diagnosis of(gastric antrum)intramucosal well-differentiated adenocarcinoma was histopathologically confirmed by puncture biopsy with gastroscopy guidance.She underwent radical resection(excision of both gastric tumors and ex vivo liver resection followed by autotransplantation simultaneously)followed by XELOX adjuvant chemotherapy.Without serious postoperative complications,the patient was successfully discharged on the 20th day after the operation.Pathological examination of the excised specimen indicated that gastrectomy with D2 lymph node dissection for primary gastric tumors and R0 resection for liver metastases were achieved.The resected mass was confirmed to be poorly differentiated gastric carcinoma(hepatoid adenocarcinoma with neuroendocrine differentiation)with liver metastases in segments VIII.No recurrence or metastasis within the liver was found during a 7.5-year follow-up review that began 1 mo after surgery.CONCLUSION Application of ex vivo liver resection followed by autotransplantation in radical resection for GCLM can help selected patients with intrahepatic metastases located in complex sites obtain a favorable clinical outcome.展开更多
Response of the vortical flow around a slender body of revolution at high incidence to the shift of a single nose perturbation was investigated systematically using numerical methods. A minute geometric bump was emplo...Response of the vortical flow around a slender body of revolution at high incidence to the shift of a single nose perturbation was investigated systematically using numerical methods. A minute geometric bump was employed to act as the nose perturbation, and all computations were performed for subsonic flows at incidence of 50°. The computational results show that the vortical flow is more sensitive to the perturbation located axially closer to the nose apex of a slender body. With perturbation shifting axially downstream away from nose apex, there is a critical axial location appearing. The vortical flow is less sensitive to the perturbation located axially closer to the critical axial location; when perturbation traverses axially around the critical axial location, the vortical flow switches between opposite asymmetric patterns. The eventual influence of perturbation axial location on the vortical flow lies on both its relative locations to nose apex and the critical axial location. The vortical flow is more sensitive to the perturbation located circumferentially farther away from the fore-and-aft symmetric plane of a slender body, and just the asymmetrically-located perturbation can provoke the vortical flow to asymmetry. With perturbation shifting circumferentially in sequence, the vortical flow varies by degrees in manner of a single periodicity. A convective-type of instability existing in the flow field is responsible for the influence of nose perturbation on the vortical flow.展开更多
Fire-induced pollutant dispersion under the influence of buoyancy in urban street canyons has attracted wide attention given its adverse impact on human health.This study analyzes the influences of fire source locatio...Fire-induced pollutant dispersion under the influence of buoyancy in urban street canyons has attracted wide attention given its adverse impact on human health.This study analyzes the influences of fire source location and crossflowing wind(perpendicular to the canyon centerline)on indoor and outdoor air pollutant dispersion in an idealized urban street canyon by employing large eddy simulation.Three fire scenarios are defined according to the transverse location of the fire source:near the windward building(scenario 1),in the middle of the canyon(scenario 2),and near the leeward building(scenario 3).Results show that a re-entrainment phenomenon appears when the wind velocity reaches a critical value in scenarios 1 and 2,but it doesn't occur in scenario 3.Fire source location significantly influences the critical re-entrainment velocity.The critical velocity in scenario 1 is approximate 1.2-1.5 m/s larger than that in scenario 2.When the heat release rate is large,the critical Fr numbers are less sensitive to changes in HRR,and remain approximately constant with values of 0.47(scenario 1)and 0.37(scenario 2).When the wind velocity is large,more compartments are expected to be affected in the upper floors in all of the three scenarios,and smoke is distributed in an inverted triangle within the buildings.The indoor/outdoor temperature and pollutant concentrations are also analyzed.Our findings can provide valuable information for both human and property safety in relation to urban street canyons and their surrounding buildings.展开更多
文摘BACKGROUND Radical resection of gastric cancer liver metastases(GCLM)can increase the 5-year survival rate of GCLM patients.However,patients may lose the theoretical feasibility of surgery due to the critical location of liver metastasis in some cases.CASE SUMMARY A 29-year-old woman had a chief complaint of chronic abdominal pain for 1 year.Abdominal computed tomography and magnetic resonance imaging examinations suggested a mass of unknown pathological nature located between the first and second hila and the margin of the lower segment of the right lobe of the liver.The anterior wall of the gastric antrum was unevenly thickened.The diagnosis of(gastric antrum)intramucosal well-differentiated adenocarcinoma was histopathologically confirmed by puncture biopsy with gastroscopy guidance.She underwent radical resection(excision of both gastric tumors and ex vivo liver resection followed by autotransplantation simultaneously)followed by XELOX adjuvant chemotherapy.Without serious postoperative complications,the patient was successfully discharged on the 20th day after the operation.Pathological examination of the excised specimen indicated that gastrectomy with D2 lymph node dissection for primary gastric tumors and R0 resection for liver metastases were achieved.The resected mass was confirmed to be poorly differentiated gastric carcinoma(hepatoid adenocarcinoma with neuroendocrine differentiation)with liver metastases in segments VIII.No recurrence or metastasis within the liver was found during a 7.5-year follow-up review that began 1 mo after surgery.CONCLUSION Application of ex vivo liver resection followed by autotransplantation in radical resection for GCLM can help selected patients with intrahepatic metastases located in complex sites obtain a favorable clinical outcome.
基金Supported by the Innovating-Fostering Foundation for PhD Candidates in Nanjing University of Science and Technology
文摘Response of the vortical flow around a slender body of revolution at high incidence to the shift of a single nose perturbation was investigated systematically using numerical methods. A minute geometric bump was employed to act as the nose perturbation, and all computations were performed for subsonic flows at incidence of 50°. The computational results show that the vortical flow is more sensitive to the perturbation located axially closer to the nose apex of a slender body. With perturbation shifting axially downstream away from nose apex, there is a critical axial location appearing. The vortical flow is less sensitive to the perturbation located axially closer to the critical axial location; when perturbation traverses axially around the critical axial location, the vortical flow switches between opposite asymmetric patterns. The eventual influence of perturbation axial location on the vortical flow lies on both its relative locations to nose apex and the critical axial location. The vortical flow is more sensitive to the perturbation located circumferentially farther away from the fore-and-aft symmetric plane of a slender body, and just the asymmetrically-located perturbation can provoke the vortical flow to asymmetry. With perturbation shifting circumferentially in sequence, the vortical flow varies by degrees in manner of a single periodicity. A convective-type of instability existing in the flow field is responsible for the influence of nose perturbation on the vortical flow.
基金This work was sponsored by the National Natural Science Foundation of Shandong Province(No.ZR2020QE279)Shandong Jianzhu University Doctoral Fund(No.X19055Z)Plan of Guidance and Cultivation for Young Innovative Talents of Shandong Province.
文摘Fire-induced pollutant dispersion under the influence of buoyancy in urban street canyons has attracted wide attention given its adverse impact on human health.This study analyzes the influences of fire source location and crossflowing wind(perpendicular to the canyon centerline)on indoor and outdoor air pollutant dispersion in an idealized urban street canyon by employing large eddy simulation.Three fire scenarios are defined according to the transverse location of the fire source:near the windward building(scenario 1),in the middle of the canyon(scenario 2),and near the leeward building(scenario 3).Results show that a re-entrainment phenomenon appears when the wind velocity reaches a critical value in scenarios 1 and 2,but it doesn't occur in scenario 3.Fire source location significantly influences the critical re-entrainment velocity.The critical velocity in scenario 1 is approximate 1.2-1.5 m/s larger than that in scenario 2.When the heat release rate is large,the critical Fr numbers are less sensitive to changes in HRR,and remain approximately constant with values of 0.47(scenario 1)and 0.37(scenario 2).When the wind velocity is large,more compartments are expected to be affected in the upper floors in all of the three scenarios,and smoke is distributed in an inverted triangle within the buildings.The indoor/outdoor temperature and pollutant concentrations are also analyzed.Our findings can provide valuable information for both human and property safety in relation to urban street canyons and their surrounding buildings.
