A wood logistics system was combined with a linear programming (LP) method utilizing GIS-based techniques on the platform of GIS software-ARC/INFO. The combined costs of road and off-road transport were taken as the o...A wood logistics system was combined with a linear programming (LP) method utilizing GIS-based techniques on the platform of GIS software-ARC/INFO. The combined costs of road and off-road transport were taken as the objective function to find the least cost route and the optimal landing locations of wood transportation. Then transport costs and allowable wood volume of stands were calculated. An LP model was developed to allocate timber resources among mills in order to minimize the wood logistics costs from harvesting sites to mills. The parameters of the LP model, including the transport costs, allowable wood volume and wood orders, were written into a text file in MPS format which were then accessed by LINDO to solve the LP problem. The system is an effective tool to manage logistics, information and funds together in order to increase the speed of wood logistics and reduce the cost. The benefits and efficiency of mill cluster can be improved. The focal firm in the cluster can be competitive.展开更多
目的 探讨在真实世界中鹿瓜多肽注射液治疗骨关节炎的人群特征及联合用药情况,并通过构建靶点网络预测其作用机制。方法 通过调取医院信息系统(hospital information systeam,HIS)数据库中使用过鹿瓜多肽注射液治疗骨关节炎患者信息,使...目的 探讨在真实世界中鹿瓜多肽注射液治疗骨关节炎的人群特征及联合用药情况,并通过构建靶点网络预测其作用机制。方法 通过调取医院信息系统(hospital information systeam,HIS)数据库中使用过鹿瓜多肽注射液治疗骨关节炎患者信息,使用SAS9.2及R软件对其使用人群特征及用药情况进行统计;通过分析应用鹿瓜多肽注射液的骨关节炎患者的治疗结局以判断其有效性,并与未使用鹿瓜多肽的骨关节炎患者的治疗结局进行对比分析;Clementine 12.0对联合用药情况进行关联规则分析,并按照置信度排序;利用CNKI、TCMSP数据库及Cytoscape软件构建“疾病-药物-成分-靶点”网络及蛋白相互作用网络,并进行拓扑学分析筛选核心成分与核心靶点;将药物靶点与疾病靶点的交集靶点进行基因本体(gene ontology,GO)及京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)富集分析;最后将核心成分与核心靶点进行分子对接。结果 4050例骨关节炎患者中,46~65岁年龄段最多(2248例,55.51%),其次为66~75岁年龄段(850例,20.99%),其中女性患者占多数(2657例,70.35%)。4050例应用鹿瓜多肽注射液治疗的骨关节炎患者的总有效率为97.88%,对比未应用鹿瓜多肽注射液的骨关节炎患者的治疗效果,显示鹿瓜多肽注射液疗效更好。关联规则显示鹿瓜多肽注射液治疗骨关节炎常与激素(倍他米松)、抗生素(头孢唑啉)、抗炎镇痛药(骨肽注射剂)、补肾壮骨剂(金天格胶囊)、活血化瘀剂(脉血康胶囊)合并用药。靶点网络分析得到核心成分棕榈酸、肉豆蔻酸、色氨酸、维生素A等10种;核心靶点过氧化物酶体增殖物激活受体(peroxisomeproliferator-activatedreceptorgamma,PPARG)、髓过氧物酶(myeloperoxidase,MPO)、受体型酪氨酸蛋白磷酸酶C(receptor-type tyrosine-protein phosphatase C,PTPRC)等9个,其中分子对接较好的组合:维生素A与丝裂原活化蛋�展开更多
缺血性中风病急性期患者在临床实践中常联合使用中成药和西药,该研究选择来源于14家三级甲等医院信息系统（hospital information system,HIS）中的27 678例缺血性中风病患者作为研究对象,以入院14 d内针对中风治疗的中西药物构建复杂网...缺血性中风病急性期患者在临床实践中常联合使用中成药和西药,该研究选择来源于14家三级甲等医院信息系统（hospital information system,HIS）中的27 678例缺血性中风病患者作为研究对象,以入院14 d内针对中风治疗的中西药物构建复杂网络,发现该网络具有无尺度现象,采用层次结构核心算法分别对急、危、一般3类入院病情患者入院1 d内,2~3,4~7,8~14 d 4个时间段的中西药物使用进行分析,发现3类入院病情患者核心中成药使用主要为活血化瘀和化痰醒脑药物,化痰醒脑药随时间变化在各类患者中使用逐渐减少。核心西药主要为抗血小板药、改善循环药物、神经保护药、抗凝药和脱水药,脱水药在入院病情为危的患者入院14 d内均为核心药物,而入院病情为一般的患者在入院3 d内作为核心药物使用,神经保护药的使用在患者入院7 d后逐渐下降。中西药物组合主要为神经保护药＋活血化瘀药、抗血小板药＋活血化瘀药、改善微循环药＋活血化瘀药;化痰醒脑药在入院病情急和一般的患者中主要与神经保护药联合使用,而入院病情为危的患者多与脱水药联合使用。该研究以大数据分析和复杂网络建模发现缺血性中风病患者急性期中西药物使用的动态特征和药物联合应用特点,为缺血性中风病急性期治疗策略的制定提供参考。展开更多
文摘A wood logistics system was combined with a linear programming (LP) method utilizing GIS-based techniques on the platform of GIS software-ARC/INFO. The combined costs of road and off-road transport were taken as the objective function to find the least cost route and the optimal landing locations of wood transportation. Then transport costs and allowable wood volume of stands were calculated. An LP model was developed to allocate timber resources among mills in order to minimize the wood logistics costs from harvesting sites to mills. The parameters of the LP model, including the transport costs, allowable wood volume and wood orders, were written into a text file in MPS format which were then accessed by LINDO to solve the LP problem. The system is an effective tool to manage logistics, information and funds together in order to increase the speed of wood logistics and reduce the cost. The benefits and efficiency of mill cluster can be improved. The focal firm in the cluster can be competitive.
