Neonatal hypoxic-ischemic encephalopathy is a serious neurological disease,often resulting in long-term neurodevelopmental disorders among surviving children.However,whether these neurodevelopmental issues can be pass...Neonatal hypoxic-ischemic encephalopathy is a serious neurological disease,often resulting in long-term neurodevelopmental disorders among surviving children.However,whether these neurodevelopmental issues can be passed to offspring remains unclear.The right common carotid artery of 7-day-old parental-generation rats was subjected to permanent ligation using a vessel electrocoagulator.Neonatal hypoxic-ischemic rat models were established by subjecting the rats to 8%O2–92%N2 for 2 hours.The results showed that 24 hours after hypoxia and ischemia,pathological damage,cerebral atrophy,liquefaction,and impairment were found,and Zea-Longa scores were significantly increased.The parental-generation rats were propagated at 3 months old,and offspring were obtained.No changes in the overall brain structures of these offspring rats were identified by magnetic resonance imaging.However,the escape latency was longer and the number of platform crossings was reduced among these offspring compared with normal rats.These results indicated that the offspring of hypoxic-ischemic encephalopathy model rats displayed cognitive impairments in learning and memory.This study was approved by the Animal Care&Welfare Committee of Kunming Medical University,China in 2018(approval No.kmmu2019072).展开更多
目的观察肌电图定位定量电刺激治疗腕管综合征的临床疗效。方法对经我院确诊的100例轻中度腕管综合征的患者随机分为两组:对照组48例和治疗组52例,两组患者均给予常规药物甲钴胺治疗,治疗组同时辅予肌电图定位定量电刺激,并分别予治疗...目的观察肌电图定位定量电刺激治疗腕管综合征的临床疗效。方法对经我院确诊的100例轻中度腕管综合征的患者随机分为两组:对照组48例和治疗组52例,两组患者均给予常规药物甲钴胺治疗,治疗组同时辅予肌电图定位定量电刺激,并分别予治疗前及治疗后1个月进行肌电图检查,并结合临床表现来评价疗效。肌电图检查包括正中神经远端潜伏期(distal motor latency,DML)、感觉传导速度(sensory conduction velocity,SCV)及波幅(amplitude,AMP)。结果治疗组的肌电图改善情况即传导速度与波幅明显优于对照组,差异有统计学意义(P<0.05);临床表现改善情况优于对照组。结论肌电图定位定量电刺激可有效促进受损神经修复,恢复神经功能,值得临床推广及应用。展开更多
基金supported by the National Natural Science Foundation of China,No.81560215(FW)the Innovative Research Team Program of Science and Technology in Yunnan Province of China,No.2017HC007
文摘Neonatal hypoxic-ischemic encephalopathy is a serious neurological disease,often resulting in long-term neurodevelopmental disorders among surviving children.However,whether these neurodevelopmental issues can be passed to offspring remains unclear.The right common carotid artery of 7-day-old parental-generation rats was subjected to permanent ligation using a vessel electrocoagulator.Neonatal hypoxic-ischemic rat models were established by subjecting the rats to 8%O2–92%N2 for 2 hours.The results showed that 24 hours after hypoxia and ischemia,pathological damage,cerebral atrophy,liquefaction,and impairment were found,and Zea-Longa scores were significantly increased.The parental-generation rats were propagated at 3 months old,and offspring were obtained.No changes in the overall brain structures of these offspring rats were identified by magnetic resonance imaging.However,the escape latency was longer and the number of platform crossings was reduced among these offspring compared with normal rats.These results indicated that the offspring of hypoxic-ischemic encephalopathy model rats displayed cognitive impairments in learning and memory.This study was approved by the Animal Care&Welfare Committee of Kunming Medical University,China in 2018(approval No.kmmu2019072).
文摘目的观察肌电图定位定量电刺激治疗腕管综合征的临床疗效。方法对经我院确诊的100例轻中度腕管综合征的患者随机分为两组:对照组48例和治疗组52例,两组患者均给予常规药物甲钴胺治疗,治疗组同时辅予肌电图定位定量电刺激,并分别予治疗前及治疗后1个月进行肌电图检查,并结合临床表现来评价疗效。肌电图检查包括正中神经远端潜伏期(distal motor latency,DML)、感觉传导速度(sensory conduction velocity,SCV)及波幅(amplitude,AMP)。结果治疗组的肌电图改善情况即传导速度与波幅明显优于对照组,差异有统计学意义(P<0.05);临床表现改善情况优于对照组。结论肌电图定位定量电刺激可有效促进受损神经修复,恢复神经功能,值得临床推广及应用。
