The specific mechanisms by which acupuncture affects the central nervous system are unclear. In the International Standard Scalp Acupuncture system, acupuncture needles are applied at the middle line of the vertex, an...The specific mechanisms by which acupuncture affects the central nervous system are unclear. In the International Standard Scalp Acupuncture system, acupuncture needles are applied at the middle line of the vertex, anterior parietal-temporal oblique line, and the posterior parietal-temporal oblique line. We conducted a single-arm prospective clinical trial in which seven healthy elderly volunteers (three men and four women;50–70 years old) received International Standard Scalp Acupuncture at MS5 (the mid-sagittal line between Baihui (DU20) and Qianding (DU21)), the left MS6 (line joining Sishencong (EX-HN1) and Xuanli (GB6)), and the left MS7 (line joining DU20 and Qubin (GB7)). After acupuncture, resting-state functional magnetic resonance imaging demonstrated changes in the fractional amplitude of low frequency fluctuations and regional homogeneity in various areas, showing remarkable enhancement of regional homogeneity in the bilateral anterior cingulate, left medial frontal gyrus, supramarginal gyrus, right middle frontal gyrus, and inferior frontal gyrus. Functional connectivity based on a seed region at the right middle frontal gyrus (42, 51, 9) decreased at the bilateral medial superior frontal gyrus. Our data preliminarily indicates that the international standard scalp acupuncture in healthy elderly participants specifcally enhances the correlation between the brain regions involved in cognition and implementation of the brain network regulation system and the surrounding adjacent brain regions. The study was approved by the Ethics Committee of the China-Japan Union Hospital at Jilin University, China, on July 18, 2016 (approval No. 2016ks043).展开更多
目的:利用功能磁共振成像(Functional Magnetic Resonance Imaging,fMRI)技术观察电针针刺正常人的合谷、合谷配太冲时的即时效应和取针后的后遗效应的脑功能网络响应差异。方法:将20例健康受试者随机分为合谷组和合谷配太冲组,每组10...目的:利用功能磁共振成像(Functional Magnetic Resonance Imaging,fMRI)技术观察电针针刺正常人的合谷、合谷配太冲时的即时效应和取针后的后遗效应的脑功能网络响应差异。方法:将20例健康受试者随机分为合谷组和合谷配太冲组,每组10例。合谷组仅针刺合谷穴,合谷配太冲组则需在合谷、太冲穴同时针刺,皆得气后连上电针。采用fMRI收集针灸前、针灸中和针灸后的图像数据。脑功能连接分析的感兴趣区为面口运动区(Face Motor Area,faceMOT)、默认网络前部(Anterior Default Mode Network,aDMN)和后部(Posterior Default Mode Network,pDMN)。结果:合谷组与合谷配太冲组比较,在faceMOT针刺时双侧颞上回、中央沟盖和右侧颞上极功能连接加强,右侧中央前、后回、左侧脑岛则降低(P<0.05);而取针后右侧岛盖部/三角部额下回、双侧楔前叶功能连接增强(P<0.05)。在aDMN针刺时双侧楔前叶功能连接减弱(P<0.05);而取针后右侧颞下回、枕下回脑功能连接增强,右侧额下回则下降(P<0.05)。在pDMN针刺时右侧舌回、楔前叶、距状回脑功能连接加强,双侧距状回、楔叶则降低(P<0.05);而取针后右侧舌回、距状回增强,双侧距状回、楔叶减弱(P<0.05)。结论:合谷单穴和合谷配太冲穴在针刺时和取针后的脑功能网络响应具有差异,针刺时合谷比合谷配太冲更突出表现在听觉语言、视觉的脑区响应,而合谷配太冲更突出在面口区、运动、内脏功能和情感的脑区功能响应;取针后合谷的针刺后遗效应更多表现在情感、思维、运动语言、内脏相关脑区的响应,而合谷配太冲则表现在视觉的脑区的响应。展开更多
Resting-state functional magnetic resonance imaging has revealed disrupted brain network connectivity in adults and teenagers with cerebral palsy. However, the specific brain networks implicated in neonatal cases rema...Resting-state functional magnetic resonance imaging has revealed disrupted brain network connectivity in adults and teenagers with cerebral palsy. However, the specific brain networks implicated in neonatal cases remain poorly understood. In this study, we recruited 14 termborn infants with mild hypoxic ischemic encephalopathy and 14 term-born infants with severe hypoxic ischemic encephalopathy from Changzhou Children's Hospital, China. Resting-state functional magnetic resonance imaging data showed efficient small-world organization in whole-brain networks in both the mild and severe hypoxic ischemic encephalopathy groups. However, compared with the mild hypoxic ischemic encephalopathy group, the severe hypoxic ischemic encephalopathy group exhibited decreased local efficiency and a low clustering coefficient. The distribution of hub regions in the functional networks had fewer nodes in the severe hypoxic ischemic encephalopathy group compared with the mild hypoxic ischemic encephalopathy group. Moreover, nodal efficiency was reduced in the left rolandic operculum, left supramarginal gyrus, bilateral superior temporal gyrus, and right middle temporal gyrus. These results suggest that the topological structure of the resting state functional network in children with severe hypoxic ischemic encephalopathy is clearly distinct from that in children with mild hypoxic ischemic encephalopathy, and may be associated with impaired language, motion, and cognition. These data indicate that it may be possible to make early predictions regarding brain development in children with severe hypoxic ischemic encephalopathy, enabling early interventions targeting brain function. This study was approved by the Regional Ethics Review Boards of the Changzhou Children's Hospital(approval No. 2013-001) on January 31, 2013. Informed consent was obtained from the family members of the children. The trial was registered with the Chinese Clinical Trial Registry(registration number: ChiCTR1800016409) and the protocol version is 1.0.展开更多
睡眠分期是评估睡眠质量的基础。然而,睡眠呼吸暂停(sleep apnea,SA)会改变测试者的睡眠结构,进而影响对睡眠分期的准确评估。因此,在评估睡眠质量时,准确检测睡眠呼吸暂停和睡眠分期至关重要。为准确评估睡眠分期,本研究通过研究脑区...睡眠分期是评估睡眠质量的基础。然而,睡眠呼吸暂停(sleep apnea,SA)会改变测试者的睡眠结构,进而影响对睡眠分期的准确评估。因此,在评估睡眠质量时,准确检测睡眠呼吸暂停和睡眠分期至关重要。为准确评估睡眠分期,本研究通过研究脑区之间的功能连接,探讨了脑功能连接的相互作用关系。采用锁相值(phase locking value,PLV)在不同时间段上进行特征提取,构建功能连接网络;然后利用多个时间段的PLV进行特征融合,并通过LibSVM(library for support vector machines,LibSVM)结合分类性能优化策略的方法进行睡眠分期。同时,本研究还分析了睡眠呼吸暂停和正常呼吸对脑网络的影响。实验结果显示,睡眠呼吸暂停时的各脑区连通紧密程度大于正常呼吸时,并在子时段数为30时,睡眠分期的分类准确率达到了88.87%,呼吸暂停的检测准确率达到了93.64%。该算法在睡眠分类和呼吸暂停检测方面表现出良好性能,有助于推动脑电睡眠分类和呼吸暂停检测系统的开发和应用。展开更多
基金funded by the National Natural Science Foundation of China,No.81403455(to JQC)
文摘The specific mechanisms by which acupuncture affects the central nervous system are unclear. In the International Standard Scalp Acupuncture system, acupuncture needles are applied at the middle line of the vertex, anterior parietal-temporal oblique line, and the posterior parietal-temporal oblique line. We conducted a single-arm prospective clinical trial in which seven healthy elderly volunteers (three men and four women;50–70 years old) received International Standard Scalp Acupuncture at MS5 (the mid-sagittal line between Baihui (DU20) and Qianding (DU21)), the left MS6 (line joining Sishencong (EX-HN1) and Xuanli (GB6)), and the left MS7 (line joining DU20 and Qubin (GB7)). After acupuncture, resting-state functional magnetic resonance imaging demonstrated changes in the fractional amplitude of low frequency fluctuations and regional homogeneity in various areas, showing remarkable enhancement of regional homogeneity in the bilateral anterior cingulate, left medial frontal gyrus, supramarginal gyrus, right middle frontal gyrus, and inferior frontal gyrus. Functional connectivity based on a seed region at the right middle frontal gyrus (42, 51, 9) decreased at the bilateral medial superior frontal gyrus. Our data preliminarily indicates that the international standard scalp acupuncture in healthy elderly participants specifcally enhances the correlation between the brain regions involved in cognition and implementation of the brain network regulation system and the surrounding adjacent brain regions. The study was approved by the Ethics Committee of the China-Japan Union Hospital at Jilin University, China, on July 18, 2016 (approval No. 2016ks043).
基金supported by the Jiangsu Maternal and Child Health Research Project of China,No.F201612(to HXL)Changzhou Science and Technology Support Plan of China,No.CE20165027(to HXL)+1 种基金Changzhou City Planning Commission Major Science and Technology Projects of China,No.ZD201515(to HXL)Changzhou High Level Training Fund for Health Professionals of China,No.2016CZBJ028(to HXL)
文摘Resting-state functional magnetic resonance imaging has revealed disrupted brain network connectivity in adults and teenagers with cerebral palsy. However, the specific brain networks implicated in neonatal cases remain poorly understood. In this study, we recruited 14 termborn infants with mild hypoxic ischemic encephalopathy and 14 term-born infants with severe hypoxic ischemic encephalopathy from Changzhou Children's Hospital, China. Resting-state functional magnetic resonance imaging data showed efficient small-world organization in whole-brain networks in both the mild and severe hypoxic ischemic encephalopathy groups. However, compared with the mild hypoxic ischemic encephalopathy group, the severe hypoxic ischemic encephalopathy group exhibited decreased local efficiency and a low clustering coefficient. The distribution of hub regions in the functional networks had fewer nodes in the severe hypoxic ischemic encephalopathy group compared with the mild hypoxic ischemic encephalopathy group. Moreover, nodal efficiency was reduced in the left rolandic operculum, left supramarginal gyrus, bilateral superior temporal gyrus, and right middle temporal gyrus. These results suggest that the topological structure of the resting state functional network in children with severe hypoxic ischemic encephalopathy is clearly distinct from that in children with mild hypoxic ischemic encephalopathy, and may be associated with impaired language, motion, and cognition. These data indicate that it may be possible to make early predictions regarding brain development in children with severe hypoxic ischemic encephalopathy, enabling early interventions targeting brain function. This study was approved by the Regional Ethics Review Boards of the Changzhou Children's Hospital(approval No. 2013-001) on January 31, 2013. Informed consent was obtained from the family members of the children. The trial was registered with the Chinese Clinical Trial Registry(registration number: ChiCTR1800016409) and the protocol version is 1.0.
文摘睡眠分期是评估睡眠质量的基础。然而,睡眠呼吸暂停(sleep apnea,SA)会改变测试者的睡眠结构,进而影响对睡眠分期的准确评估。因此,在评估睡眠质量时,准确检测睡眠呼吸暂停和睡眠分期至关重要。为准确评估睡眠分期,本研究通过研究脑区之间的功能连接,探讨了脑功能连接的相互作用关系。采用锁相值(phase locking value,PLV)在不同时间段上进行特征提取,构建功能连接网络;然后利用多个时间段的PLV进行特征融合,并通过LibSVM(library for support vector machines,LibSVM)结合分类性能优化策略的方法进行睡眠分期。同时,本研究还分析了睡眠呼吸暂停和正常呼吸对脑网络的影响。实验结果显示,睡眠呼吸暂停时的各脑区连通紧密程度大于正常呼吸时,并在子时段数为30时,睡眠分期的分类准确率达到了88.87%,呼吸暂停的检测准确率达到了93.64%。该算法在睡眠分类和呼吸暂停检测方面表现出良好性能,有助于推动脑电睡眠分类和呼吸暂停检测系统的开发和应用。
