Diabetes mellitus is a chronic condition that occurs when the body cannot produce enough or effectively use of insulin.Compared with individuals without diabetes,patients with type 2 diabetes mellitus have a considera...Diabetes mellitus is a chronic condition that occurs when the body cannot produce enough or effectively use of insulin.Compared with individuals without diabetes,patients with type 2 diabetes mellitus have a considerably higher risk of cardiovascular morbidity and mortality,and are disproportionately affected by cardiovascular disease.Most of this excess risk is it associated with an augmented prevalence of well-known risk factors such as hypertension,dyslipidaemia and obesity in these patients.However the improved cardiovascular disease in type 2 diabetes mellitus patients can not be attributed solely to the higher prevalence of traditional risk factors.Therefore other non-traditional risk factors may be important in people with type 2 diabetes mellitus.Cardiovascular disease is increased in type 2 diabetes mellitus subjects due to a complex combination of various traditional and non-traditional risk factors that have an important role to play in the beginning and the evolution of atherosclerosis over its long natural history from endothelial function to clinical events.Many of these risk factors could be common history for both di-abetes mellitus and cardiovascular disease,reinforcing the postulate that both disorders come independently from"common soil".The objective of this review is to highlight the weight of traditional and non-traditional risk factors for cardiovascular disease in the setting of type 2 diabetes mellitus and discuss their position in the pathogenesis of the excess cardiovascular disease mortality and morbidity in these patients.展开更多
目的观察阿卡波糖联合甘精胰岛素对2型糖尿病患者胰岛功能、血脂水平的影响及安全性。方法选取2018年1月—2020年12月就诊的102例2型糖尿病,根据治疗方式不同分为对照组48例和研究组54例,对照组给予阿卡波糖联合普通胰岛素治疗,研究组...目的观察阿卡波糖联合甘精胰岛素对2型糖尿病患者胰岛功能、血脂水平的影响及安全性。方法选取2018年1月—2020年12月就诊的102例2型糖尿病,根据治疗方式不同分为对照组48例和研究组54例,对照组给予阿卡波糖联合普通胰岛素治疗,研究组给予阿卡波糖联合甘精胰岛素治疗。比较两组治疗前后胰岛功能[稳态模型胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)]、血糖[空腹血糖(FPG)、餐后2 h血糖(2 h PG)及糖化血红蛋白(HbA1c)]、血脂[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]水平,并观察不良反应发生情况。结果治疗后,两组FPG、2 h PG、HbA1c、TC、TG、LDL-C及HOMA-IR水平均较治疗前降低,HDL-C及HOMA-β水平均较治疗前升高,且研究组上述指标降低或升高程度较对照组更为明显(P<0.05)。两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论阿卡波糖联合甘精胰岛素治疗能够有效控制2型糖尿病患者的血糖,并改善血脂水平及胰岛功能,且联合用药后并未增加不良反应,具有一定安全性。展开更多
文摘Diabetes mellitus is a chronic condition that occurs when the body cannot produce enough or effectively use of insulin.Compared with individuals without diabetes,patients with type 2 diabetes mellitus have a considerably higher risk of cardiovascular morbidity and mortality,and are disproportionately affected by cardiovascular disease.Most of this excess risk is it associated with an augmented prevalence of well-known risk factors such as hypertension,dyslipidaemia and obesity in these patients.However the improved cardiovascular disease in type 2 diabetes mellitus patients can not be attributed solely to the higher prevalence of traditional risk factors.Therefore other non-traditional risk factors may be important in people with type 2 diabetes mellitus.Cardiovascular disease is increased in type 2 diabetes mellitus subjects due to a complex combination of various traditional and non-traditional risk factors that have an important role to play in the beginning and the evolution of atherosclerosis over its long natural history from endothelial function to clinical events.Many of these risk factors could be common history for both di-abetes mellitus and cardiovascular disease,reinforcing the postulate that both disorders come independently from"common soil".The objective of this review is to highlight the weight of traditional and non-traditional risk factors for cardiovascular disease in the setting of type 2 diabetes mellitus and discuss their position in the pathogenesis of the excess cardiovascular disease mortality and morbidity in these patients.
文摘目的观察阿卡波糖联合甘精胰岛素对2型糖尿病患者胰岛功能、血脂水平的影响及安全性。方法选取2018年1月—2020年12月就诊的102例2型糖尿病,根据治疗方式不同分为对照组48例和研究组54例,对照组给予阿卡波糖联合普通胰岛素治疗,研究组给予阿卡波糖联合甘精胰岛素治疗。比较两组治疗前后胰岛功能[稳态模型胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)]、血糖[空腹血糖(FPG)、餐后2 h血糖(2 h PG)及糖化血红蛋白(HbA1c)]、血脂[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]水平,并观察不良反应发生情况。结果治疗后,两组FPG、2 h PG、HbA1c、TC、TG、LDL-C及HOMA-IR水平均较治疗前降低,HDL-C及HOMA-β水平均较治疗前升高,且研究组上述指标降低或升高程度较对照组更为明显(P<0.05)。两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论阿卡波糖联合甘精胰岛素治疗能够有效控制2型糖尿病患者的血糖,并改善血脂水平及胰岛功能,且联合用药后并未增加不良反应,具有一定安全性。
