摘要
目的了解医院血培养的病原菌分布以及耐药性,为临床合理使用抗菌药物提供科学依据。方法对2009年1月-2015年12月从血标本中分离的病原菌分布和药物敏感试验结果进行回顾性分析,数据采用WHONET5.6软件进行分析。结果 2009年1月-2015年12月医院35 368份血培养标本共分离病原菌2 375株,阳性率为6.72%,其中革兰阴性杆菌1 341株(56.46%),革兰阳性球菌905株(38.11%),真菌104株(4.38%);大肠埃希菌和肺炎克雷白菌出现耐亚胺培南菌株;葡萄球菌对利奈唑胺、万古霉素和喹奴普汀/达福普汀非常敏感;屎肠球菌整体耐药率较粪肠球菌高。结论医院血培养的病原菌以革兰阴性菌为主,肠杆菌科出现碳青霉烯耐药菌株,加强监测血培养病原菌变化及耐药趋势,对指导临床用药至关重要。
OBJECTIVE To investigate the distribution and antimicrobial resistance of pathogenic bacteria in blood culture,so as to provide a basis for the rational use of antibiotics in clinic.METHODS The distribution and the results of antimicrobial susceptibility testing and characteristics of the pathogenic bacteria isolated from blood culture samples from Jan.2009 to Dec.2015 in our hospital were retrospectively analyzed.WHONET 5.6was applied for analysis.RESULTS The results showed that 2 372 pathogens were isolated from 35 368 blood culture samples from Jan.2009 to Dec.2015 in our hospital,and the positive rate was 6.72%,including 1 341（56.46%）strains of gram-negative bacteria,905（38.11%）strains of gram-positive bacteria,and 104（4.38%）strains of fungi.Imipenem-resistant strains were found in Escherichia coil and Klebsiella pneumonia.The antimicrobial susceptibilities of Staphylococci to linezolid,vancimycin and quinupristin/dalfopristin were highly sensitive.The antimicrobial resistant rates of E.faecalis strains were much higher than those of E.faecium.CONCLUSION Gramnegative bacteria are the main pathogens of blood culture in our hospital and cabapenem-resistant strains were appeared in Enterobacteriaceae.Monitoring the changes of pathogens and trends of antimicrobial resistance was very important to guide clinical medication.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第3期535-538,共4页
Chinese Journal of Nosocomiology
基金
北京市医管局首届登峰人才计划基金资助项目(DFL20150701)
关键词
血培养
病原菌
分布
耐药性
Blood culture
Pathogen
Distribution
Antimicrobial resistance
