Objective：Clinical application ofautologous fat grafting （AFG） is quickly expanding.Despite the widely acceptance,long-term survival rate （SR） of AFG remains a question not yet solved.Meanwhile,although rare,seve...Objective：Clinical application ofautologous fat grafting （AFG） is quickly expanding.Despite the widely acceptance,long-term survival rate （SR） of AFG remains a question not yet solved.Meanwhile,although rare,severe complications related to AFG including vision loss,stroke even death could be seen in the literature.Data Sources：A comprehensive research of PubMed database to June 2013 was performed according to guidelines of the American Society of Plastic Surgeons Fat Graft Task Force Assessment Methodology.Articles were screened using predetermined inclusion and exclusion criteria.Study Selection：Data collected included patient characteristics,surgical technique,donor site,recipient site,graft amount,and quantified measurement methods.Patient cohorts were pooled,and SR was calculated.All the severe complications were also summarized according to the different clinical characteristics.Results：Of 550 articles,16 clinical articles and 10 animal studies met the inclusion criteria and provided quantified measurement methods.Totally,596 patients were included.SR varied from 34％ to 82％ in breast and 30-83％ in the facial area.Nude mice were applied to investigate human fat grafting SR （38.3-52.5％ after 15 weeks）.Rabbits were commonly used to study animal AFG SR （14.00-14.56％ after 1-year）.Totally,21 severe complications were reported,including death （2）,stroke （10）,vision loss （11,8 of which accompanied with stroke）,sepsis （3）,multiple abscess （1） and giant fat necrotic cyst （2）.Ten of these complications happened within 10 years.Conclusions：There is no unified measurement method to evaluate fat graft SR until now and no clinical evidence to show better SR according to different donor and recipient cite.Body mass index change between pre-and postoperation may be the bias factor in evaluating fat SR.Fat embolisms of the ophthalmic artery and the middle cerebral artery are the most severe complication of AFG and still lack of effective treatment.展开更多
目的探讨应用自体脂肪颗粒移植改善鼻唇沟凹陷的效果。方法 2011年11月至2014年12月,利用自体脂肪颗粒注射填充鼻唇沟凹陷91例。选取腰腹部或大腿作为脂肪供区,利用负压吸脂机获取脂肪颗粒,吸水浓缩法纯化后,多层次、多隧道、多点少量...目的探讨应用自体脂肪颗粒移植改善鼻唇沟凹陷的效果。方法 2011年11月至2014年12月,利用自体脂肪颗粒注射填充鼻唇沟凹陷91例。选取腰腹部或大腿作为脂肪供区,利用负压吸脂机获取脂肪颗粒,吸水浓缩法纯化后,多层次、多隧道、多点少量注射填充91例患者的鼻唇沟凹陷。结果术后随访6~36个月,56例患者一次注射填充即达满意效果,35例患者经过两次注射填充达到满意效果。每侧注射量1.2~4.6 m L。本组患者均无严重并发症。结论自体脂肪颗粒移植注射填充鼻唇沟凹陷,效果优良,并发症少,值得临床推广应用。展开更多
文摘Objective：Clinical application ofautologous fat grafting （AFG） is quickly expanding.Despite the widely acceptance,long-term survival rate （SR） of AFG remains a question not yet solved.Meanwhile,although rare,severe complications related to AFG including vision loss,stroke even death could be seen in the literature.Data Sources：A comprehensive research of PubMed database to June 2013 was performed according to guidelines of the American Society of Plastic Surgeons Fat Graft Task Force Assessment Methodology.Articles were screened using predetermined inclusion and exclusion criteria.Study Selection：Data collected included patient characteristics,surgical technique,donor site,recipient site,graft amount,and quantified measurement methods.Patient cohorts were pooled,and SR was calculated.All the severe complications were also summarized according to the different clinical characteristics.Results：Of 550 articles,16 clinical articles and 10 animal studies met the inclusion criteria and provided quantified measurement methods.Totally,596 patients were included.SR varied from 34％ to 82％ in breast and 30-83％ in the facial area.Nude mice were applied to investigate human fat grafting SR （38.3-52.5％ after 15 weeks）.Rabbits were commonly used to study animal AFG SR （14.00-14.56％ after 1-year）.Totally,21 severe complications were reported,including death （2）,stroke （10）,vision loss （11,8 of which accompanied with stroke）,sepsis （3）,multiple abscess （1） and giant fat necrotic cyst （2）.Ten of these complications happened within 10 years.Conclusions：There is no unified measurement method to evaluate fat graft SR until now and no clinical evidence to show better SR according to different donor and recipient cite.Body mass index change between pre-and postoperation may be the bias factor in evaluating fat SR.Fat embolisms of the ophthalmic artery and the middle cerebral artery are the most severe complication of AFG and still lack of effective treatment.
文摘目的探讨应用自体脂肪颗粒移植改善鼻唇沟凹陷的效果。方法 2011年11月至2014年12月,利用自体脂肪颗粒注射填充鼻唇沟凹陷91例。选取腰腹部或大腿作为脂肪供区,利用负压吸脂机获取脂肪颗粒,吸水浓缩法纯化后,多层次、多隧道、多点少量注射填充91例患者的鼻唇沟凹陷。结果术后随访6~36个月,56例患者一次注射填充即达满意效果,35例患者经过两次注射填充达到满意效果。每侧注射量1.2~4.6 m L。本组患者均无严重并发症。结论自体脂肪颗粒移植注射填充鼻唇沟凹陷,效果优良,并发症少,值得临床推广应用。
