Objective:To investigate the antidiarrheal activity of the methanol leaf extract of Pterocarpus erinaceus in vivo.Methods:The methanol leaf extract of Ptemcarpus erinaceus was evaluated using different doses(100,200 a...Objective:To investigate the antidiarrheal activity of the methanol leaf extract of Pterocarpus erinaceus in vivo.Methods:The methanol leaf extract of Ptemcarpus erinaceus was evaluated using different doses(100,200 and 400 mg/kg body weight) orally for antidiarrheal activity using castor oil-induced diarrhea,charcoal meal transit lime and castor oil-induced enteropooling in different groups of albino Wistar mice.The activity of the extract at different doses were compared to diphenoxylate(3 mg/kg) and atropine sulphate(3 mg/kg) which were used as standard reference drugs and also to the distilled water administered negative control group of mice.Results:The extract at the doses used caused a significant(P【 0.01) reduction in the wet faeces passed by the mice in the castor oil-induced diarrhea,decreased the distance travelled by the charcoal meal by up to 54.8%and also caused a dose dependent and significant(P【 0.001) reduction in the intraluminal fluid accumulation in the castor oil-induced enteropooling. Conclusions:Our results indicate that Pterocarpits erinaceus extract produced significant antidiarrheal activity and the action may attribute to inhibition of gastrointestinal movement and fluid secretion.展开更多
文摘Objective:To investigate the antidiarrheal activity of the methanol leaf extract of Pterocarpus erinaceus in vivo.Methods:The methanol leaf extract of Ptemcarpus erinaceus was evaluated using different doses(100,200 and 400 mg/kg body weight) orally for antidiarrheal activity using castor oil-induced diarrhea,charcoal meal transit lime and castor oil-induced enteropooling in different groups of albino Wistar mice.The activity of the extract at different doses were compared to diphenoxylate(3 mg/kg) and atropine sulphate(3 mg/kg) which were used as standard reference drugs and also to the distilled water administered negative control group of mice.Results:The extract at the doses used caused a significant(P【 0.01) reduction in the wet faeces passed by the mice in the castor oil-induced diarrhea,decreased the distance travelled by the charcoal meal by up to 54.8%and also caused a dose dependent and significant(P【 0.001) reduction in the intraluminal fluid accumulation in the castor oil-induced enteropooling. Conclusions:Our results indicate that Pterocarpits erinaceus extract produced significant antidiarrheal activity and the action may attribute to inhibition of gastrointestinal movement and fluid secretion.
文摘目的探索在^(60)Co-γ辐照条件下不同因素(辐照剂量、初始浓度、N_2/O_2饱和及自由基清除剂等)对硫酸阿托品稳定性的影响。方法分别配制不同准确初始浓度的硫酸阿托品溶液(10、50、100 mg/L、100 mg/L+N_2饱和、100 mg/L+O_2饱和、100 mg/L+10%乙醇及硫酸阿托品粉末)等,经不同辐照剂量(0.3、0.6、1、2.5、5、10 k Gy)的^(60)Co-γ辐照后,利用HPLC测定溶液中剩余硫酸阿托品的含量。结果 (1)在相同辐照剂量下,初始浓度越大,稳定性越好;在相同初始浓度下,辐照剂量越大,稳定性越差;(2)N_2/O_2饱和并未显著改善硫酸阿托品的稳定性;(3)添加自由基清除剂乙醇后,硫酸阿托品的稳定性显著提高;(4)硫酸阿托品粉末状态非常稳定,即使在10 k Gy辐照剂量下,降解不超过10%。结论硫酸阿托品溶液对^(60)Co-γ辐照敏感,为了在辐照环境下尽量保持硫酸阿托品稳定性,可尝试将其制成粉末剂型。
