妊娠期高血压疾病(hypertensive disorders in pregnancy,HDP)是妊娠与血压升高并存的一组疾病。加强孕期的监测和孕期血压的管理是预防子痫前期、改善母婴结局的关键。血压和蛋白尿是孕期监测的重点。指南推荐可用于孕期的降压药物包...妊娠期高血压疾病(hypertensive disorders in pregnancy,HDP)是妊娠与血压升高并存的一组疾病。加强孕期的监测和孕期血压的管理是预防子痫前期、改善母婴结局的关键。血压和蛋白尿是孕期监测的重点。指南推荐可用于孕期的降压药物包括甲基多巴、拉贝洛尔或硝苯地平等。子痫前期的早期筛查和干预是女性孕期心血管风险防范的关键之一。除药物干预之外,体重控制、生活方式干预、筛查和治疗阻塞性睡眠呼吸暂停等也不容忽视。展开更多
目的系统评价阿司匹林联合氯吡格雷治疗急性脑梗死的疗效。方法检索2000年1月至2016年3月Pub Med、中国知网(CNKI)、万方数据库和重庆维普数据库中阿司匹林联合氯吡格雷治疗急性脑梗死的相关文献,并应用Stata 11.0软件对符合入选标准的...目的系统评价阿司匹林联合氯吡格雷治疗急性脑梗死的疗效。方法检索2000年1月至2016年3月Pub Med、中国知网(CNKI)、万方数据库和重庆维普数据库中阿司匹林联合氯吡格雷治疗急性脑梗死的相关文献,并应用Stata 11.0软件对符合入选标准的文献进行异质性检验和效应值合并,综合分析各种偏倚及效应值。结果纳入符合条件的相关文献共17篇,其中实验组925例,对照组923例。阿司匹林联合氯吡格雷治疗急性脑梗死的有效率高于对照组,合并OR值(95%CI)为3.76(2.75~5.14),P<0.05;阿司匹林联合氯吡格雷可以降低患者的神经功能缺损(National Institutes of Health Stroke Scale,NIHSS)评分,SMD值(95%CI)为-1.77(-1.58^-0.76),P<0.05。结论阿司匹林联合氯吡格雷治疗急性脑梗死具有显著的疗效,可以提高治疗有效率,改善患者的预后。展开更多
Restorative materials in the new era aim to be “bio-active” and long-lasting. It has been suggested that the anti-inflammatory activity of some non-steroidal anti-inflammatory drugs (NSAIDs) may be partly due to the...Restorative materials in the new era aim to be “bio-active” and long-lasting. It has been suggested that the anti-inflammatory activity of some non-steroidal anti-inflammatory drugs (NSAIDs) may be partly due to their ability to scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as to inhibit the respiratory burst of neutrophils triggered by various activating agents. As a part of our continuous interest of developing functional dual action restorative materials capable of being “bio-active” and long-lasting, we design and evaluate novel chitosan hydrogels containing krill oil (antioxidant containing material), naproxen, ibuprofen (non steroidal anti-inflammatory medication), aspirin (pain relieve medication and free radical scavengers) and combinations thereof (chitosan-H-krill oil, chitosan-H-krill oil-aspirin and chitosan-H-naproxen, chitosan-H-naproxen-krill oil, chitosan-H-krill oil-ibuprofen and chitosan-H-ibuprofen) as functional additive prototypes for further development of “dual function restorative materials”;secondly, determine their effect on the dentin bond strength of a composite and thirdly, evaluate the capability of newly designed hydrogels to play an integral role of “build in” free radical defense mechanism by using BSA solubility as a “molecular prototype” of the site of free radical attack in vitro. Materials and Methods: The above mentioned hydrogels were prepared by dispersion of the corresponding component in glycerol and acetic acid with the addition of chitosan gelling agent. The surface morphology (SEM), release behaviors (physiological pH and also in acidic conditions), stability of the therapeutic agent-antioxidant-chitosan and the effect of the hydrogels on the shear bond strength of dentin were also evaluated. Results: The release of aspirin, ibuprofen and naproxen confers the added benefit of synergistic action of a functional therapeutic delivery when comparing the newly designed chitosan-based hydrogel restorative materials to展开更多
文摘妊娠期高血压疾病(hypertensive disorders in pregnancy,HDP)是妊娠与血压升高并存的一组疾病。加强孕期的监测和孕期血压的管理是预防子痫前期、改善母婴结局的关键。血压和蛋白尿是孕期监测的重点。指南推荐可用于孕期的降压药物包括甲基多巴、拉贝洛尔或硝苯地平等。子痫前期的早期筛查和干预是女性孕期心血管风险防范的关键之一。除药物干预之外,体重控制、生活方式干预、筛查和治疗阻塞性睡眠呼吸暂停等也不容忽视。
文摘目的系统评价阿司匹林联合氯吡格雷治疗急性脑梗死的疗效。方法检索2000年1月至2016年3月Pub Med、中国知网(CNKI)、万方数据库和重庆维普数据库中阿司匹林联合氯吡格雷治疗急性脑梗死的相关文献,并应用Stata 11.0软件对符合入选标准的文献进行异质性检验和效应值合并,综合分析各种偏倚及效应值。结果纳入符合条件的相关文献共17篇,其中实验组925例,对照组923例。阿司匹林联合氯吡格雷治疗急性脑梗死的有效率高于对照组,合并OR值(95%CI)为3.76(2.75~5.14),P<0.05;阿司匹林联合氯吡格雷可以降低患者的神经功能缺损(National Institutes of Health Stroke Scale,NIHSS)评分,SMD值(95%CI)为-1.77(-1.58^-0.76),P<0.05。结论阿司匹林联合氯吡格雷治疗急性脑梗死具有显著的疗效,可以提高治疗有效率,改善患者的预后。
文摘Restorative materials in the new era aim to be “bio-active” and long-lasting. It has been suggested that the anti-inflammatory activity of some non-steroidal anti-inflammatory drugs (NSAIDs) may be partly due to their ability to scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as to inhibit the respiratory burst of neutrophils triggered by various activating agents. As a part of our continuous interest of developing functional dual action restorative materials capable of being “bio-active” and long-lasting, we design and evaluate novel chitosan hydrogels containing krill oil (antioxidant containing material), naproxen, ibuprofen (non steroidal anti-inflammatory medication), aspirin (pain relieve medication and free radical scavengers) and combinations thereof (chitosan-H-krill oil, chitosan-H-krill oil-aspirin and chitosan-H-naproxen, chitosan-H-naproxen-krill oil, chitosan-H-krill oil-ibuprofen and chitosan-H-ibuprofen) as functional additive prototypes for further development of “dual function restorative materials”;secondly, determine their effect on the dentin bond strength of a composite and thirdly, evaluate the capability of newly designed hydrogels to play an integral role of “build in” free radical defense mechanism by using BSA solubility as a “molecular prototype” of the site of free radical attack in vitro. Materials and Methods: The above mentioned hydrogels were prepared by dispersion of the corresponding component in glycerol and acetic acid with the addition of chitosan gelling agent. The surface morphology (SEM), release behaviors (physiological pH and also in acidic conditions), stability of the therapeutic agent-antioxidant-chitosan and the effect of the hydrogels on the shear bond strength of dentin were also evaluated. Results: The release of aspirin, ibuprofen and naproxen confers the added benefit of synergistic action of a functional therapeutic delivery when comparing the newly designed chitosan-based hydrogel restorative materials to
