Background：Antimicrobial resistance is a serious problem that compromises the empirical treatment of infections,resulting in a lack of effective antibiotics and high medical expenses.Here,we aimed to monitor the tren...Background：Antimicrobial resistance is a serious problem that compromises the empirical treatment of infections,resulting in a lack of effective antibiotics and high medical expenses.Here,we aimed to monitor the trends in antimicrobial resistance among Enterobacteriaceae isolated from blood samples in China's Mainland.Methods：A total of 2240 Enterobacteriaceae isolates from blood were collected from hospitalized patients at 19 tertiary hospitals between October 2004 and June 2014.The minimum inhibitory concentrations of all isolates were determined using the agar dilution method according to the Clinical and Laboratory Standards Institute 2016 guidelines.Results：The most commonly isolated bacteria were Escherichia coli,compromising 47.0% （1053/2240） of the total isolates,followed byKlebsiella spp.（26.3%）,Sahnonella spp.（10.4%）,and Enterobacter spp.（9.2%）.The detection rates of extended-spectrum β-lactamases （ESBLs） among E.coli were 68.9% （2004-2005）,73.2% （2007-2008）,67.9% （2009-2010）,72.6% （2011-2012）,and 58.4% （2013-2014）,whereas those in ESBL-producing Klebsiellapneumoniae were slightly decreased （75.9%,50.0%,41.4%,40.2%,and 43.0%,respectively）.Carbapenems were the most potent agents against the Enterobacteriaceae isolates,followed by moxalactam,tigecycline,and amikacin.However,there was a decrease in the susceptibility rates for carbapenems in all species,particularly K.pneumoniae （decreased by 10.6% for imipenem） and Enterobacter aerogenes （decreased by 2 l.1% for imipenem）.Reviving antibiotics （tigecycline and polymyxins） showed good in vitro activity against Enterobacteriaceae.Conclusions：The activity of antibiotics against Enterobacteriaceae isolated from blood was decreased overall.Large proportions of ESBL-producing isolates were identified among E.coli and Klebsiella spp.Carbapenem-resistant isolates have become a major challenge in the treatment of infections.展开更多
A new series of N-arylquinoline derivatives 5a-x bearing 2-morpholinoquinoline moiety has been synthesized by one pot base catalyzed cyclocondensation reaction of 2-morpholinoquinoline-3-carbaldehydes 2a-c,malononitri...A new series of N-arylquinoline derivatives 5a-x bearing 2-morpholinoquinoline moiety has been synthesized by one pot base catalyzed cyclocondensation reaction of 2-morpholinoquinoline-3-carbaldehydes 2a-c,malononitrile 3 andβ-enaminones 4a-h. All the synthesized compounds were screened for their in vitro antimicrobial activity against six bacterial pathogens,namely Streptococcus pneumoniae,Clostridium tetani,Bacillus subtilis,Salmonella typhi,Vibrio cholerae,Escherichia coli and against two fungal pathogens,Aspergillus fumigatus and Candida albicans using broth microdilution MIC method.Of the compounds studied,majority of the compounds were found to active against C.tetani,B.subtilis and C.albicans as compared to first-line standard drugs.展开更多
文摘Background：Antimicrobial resistance is a serious problem that compromises the empirical treatment of infections,resulting in a lack of effective antibiotics and high medical expenses.Here,we aimed to monitor the trends in antimicrobial resistance among Enterobacteriaceae isolated from blood samples in China's Mainland.Methods：A total of 2240 Enterobacteriaceae isolates from blood were collected from hospitalized patients at 19 tertiary hospitals between October 2004 and June 2014.The minimum inhibitory concentrations of all isolates were determined using the agar dilution method according to the Clinical and Laboratory Standards Institute 2016 guidelines.Results：The most commonly isolated bacteria were Escherichia coli,compromising 47.0% （1053/2240） of the total isolates,followed byKlebsiella spp.（26.3%）,Sahnonella spp.（10.4%）,and Enterobacter spp.（9.2%）.The detection rates of extended-spectrum β-lactamases （ESBLs） among E.coli were 68.9% （2004-2005）,73.2% （2007-2008）,67.9% （2009-2010）,72.6% （2011-2012）,and 58.4% （2013-2014）,whereas those in ESBL-producing Klebsiellapneumoniae were slightly decreased （75.9%,50.0%,41.4%,40.2%,and 43.0%,respectively）.Carbapenems were the most potent agents against the Enterobacteriaceae isolates,followed by moxalactam,tigecycline,and amikacin.However,there was a decrease in the susceptibility rates for carbapenems in all species,particularly K.pneumoniae （decreased by 10.6% for imipenem） and Enterobacter aerogenes （decreased by 2 l.1% for imipenem）.Reviving antibiotics （tigecycline and polymyxins） showed good in vitro activity against Enterobacteriaceae.Conclusions：The activity of antibiotics against Enterobacteriaceae isolated from blood was decreased overall.Large proportions of ESBL-producing isolates were identified among E.coli and Klebsiella spp.Carbapenem-resistant isolates have become a major challenge in the treatment of infections.
文摘A new series of N-arylquinoline derivatives 5a-x bearing 2-morpholinoquinoline moiety has been synthesized by one pot base catalyzed cyclocondensation reaction of 2-morpholinoquinoline-3-carbaldehydes 2a-c,malononitrile 3 andβ-enaminones 4a-h. All the synthesized compounds were screened for their in vitro antimicrobial activity against six bacterial pathogens,namely Streptococcus pneumoniae,Clostridium tetani,Bacillus subtilis,Salmonella typhi,Vibrio cholerae,Escherichia coli and against two fungal pathogens,Aspergillus fumigatus and Candida albicans using broth microdilution MIC method.Of the compounds studied,majority of the compounds were found to active against C.tetani,B.subtilis and C.albicans as compared to first-line standard drugs.
