目的观察白芷的有效成分白芷香豆素（Coumarin of Angelicae daburicae，CAD）的抗炎作用．方法采用小鼠巴豆油耳肿胀实验、冰醋酸致小鼠腹腔毛细血管通透性增高实验及小鼠角叉菜胶足肿胀实验观察CAD的抗炎作用．结果CAD（60，120mg...目的观察白芷的有效成分白芷香豆素（Coumarin of Angelicae daburicae，CAD）的抗炎作用．方法采用小鼠巴豆油耳肿胀实验、冰醋酸致小鼠腹腔毛细血管通透性增高实验及小鼠角叉菜胶足肿胀实验观察CAD的抗炎作用．结果CAD（60，120mg·kg^-1）ig能显著抑制巴豆油所致的小鼠耳肿胀、冰醋酸引起的小鼠腹腔毛细血管通透性增强和角叉菜胶所致的小鼠足肿胀．结论CAD具有明显的抗炎作用，与对照组比较差异非常显著．展开更多
Aim To find corresponding relationship between the fingerprint of Houttuynia cordata injections from different factories and their effects.Methods Houttuynia cordata injections from six different factories were determ...Aim To find corresponding relationship between the fingerprint of Houttuynia cordata injections from different factories and their effects.Methods Houttuynia cordata injections from six different factories were determined by gas chromatography(GC) and gas chromatography-mass spectra(GC-MS),and GC fingerprints were classified by hierarchical clustering.The anti-inflammatory activity of Houttuynia cordata injections was characterized through the rat pleurisy model induced by carrageenin and the mice ear edema model by dimethylbenzene.Results The anti-inflammatory effect of the injections from the first class factories on the two model was significant,while those from the second class not.(GC-MS) analysis result indicated that main effect compounds in Houttuynia cordata injections are methyl(n-nonyl ketone),decanoylacetaldehyde,lauryl aldehyde,capryl aldehyde,(β-pinene),(βlinalool),(1-nonanol),(4-terpineol),α-terpineol,bornyl acetate, n-decanoic acid and acetic acid,geraniol ester etc.Conclusion There is corresponding relationship between the fingerprint of Houttuynia cordata injections and effect to a certain extent.展开更多
文摘目的观察白芷的有效成分白芷香豆素（Coumarin of Angelicae daburicae，CAD）的抗炎作用．方法采用小鼠巴豆油耳肿胀实验、冰醋酸致小鼠腹腔毛细血管通透性增高实验及小鼠角叉菜胶足肿胀实验观察CAD的抗炎作用．结果CAD（60，120mg·kg^-1）ig能显著抑制巴豆油所致的小鼠耳肿胀、冰醋酸引起的小鼠腹腔毛细血管通透性增强和角叉菜胶所致的小鼠足肿胀．结论CAD具有明显的抗炎作用，与对照组比较差异非常显著．
文摘Aim To find corresponding relationship between the fingerprint of Houttuynia cordata injections from different factories and their effects.Methods Houttuynia cordata injections from six different factories were determined by gas chromatography(GC) and gas chromatography-mass spectra(GC-MS),and GC fingerprints were classified by hierarchical clustering.The anti-inflammatory activity of Houttuynia cordata injections was characterized through the rat pleurisy model induced by carrageenin and the mice ear edema model by dimethylbenzene.Results The anti-inflammatory effect of the injections from the first class factories on the two model was significant,while those from the second class not.(GC-MS) analysis result indicated that main effect compounds in Houttuynia cordata injections are methyl(n-nonyl ketone),decanoylacetaldehyde,lauryl aldehyde,capryl aldehyde,(β-pinene),(βlinalool),(1-nonanol),(4-terpineol),α-terpineol,bornyl acetate, n-decanoic acid and acetic acid,geraniol ester etc.Conclusion There is corresponding relationship between the fingerprint of Houttuynia cordata injections and effect to a certain extent.
