目的:分析耳科正常青年人气导和骨导短纯音诱发的听性脑干反应(ABR)的特性,比较气骨导短纯音ABR反应阈与纯音听阈的关系,探讨气骨导短纯音ABR反应阈对听阈评估的价值。方法:30例耳科正常青年人(男/女=14/16)分别进行纯音听阈测试、气导...目的:分析耳科正常青年人气导和骨导短纯音诱发的听性脑干反应(ABR)的特性,比较气骨导短纯音ABR反应阈与纯音听阈的关系,探讨气骨导短纯音ABR反应阈对听阈评估的价值。方法:30例耳科正常青年人(男/女=14/16)分别进行纯音听阈测试、气导和骨导短声及短纯音ABR测试。结果:1气导0.5、1、2、4 k Hz短纯音诱发ABR反应阈分别较对应频率气导纯音听阈高18.41±4.47、13.18±3.63、8.86±5.10、8.64±5.16 d B,骨导0.5、1、2、4 k Hz短纯音诱发ABR反应阈分别较对应频率骨导纯音听阈高14.31±3.98、10.45±4.54、6.82±4.24、8.18±4.77 d B。2气骨导各频率短纯音ABR反应阈的差值分别为5.55±3.42、3.86±4.86、1.36±5.60、1.59±6.05 d B,0.5、1 k Hz气骨导阈值间的差异有统计学意义(P<0.01),2、4k Hz气骨导阈值间的差异无统计学意义(P>0.05)。3气骨导短纯音ABR V波潜伏期均较短声ABR长,其差异有统计学意义(P<0.01),但两者I^V波间期的差异无统计学意义(P>0.05)。结论:气骨导短纯音ABR反应阈可以预测纯音听阈,气骨导短纯音ABR反应阈的差值有助于鉴别听力损失的类型。展开更多
Objective Auditory neuropathy(AN)is a unique pattern of hearing loss with preservation of hair cell function.The condition is characterized by the presence of otoacoustic emissions(OAE)or cochlear microphonic(CM)respo...Objective Auditory neuropathy(AN)is a unique pattern of hearing loss with preservation of hair cell function.The condition is characterized by the presence of otoacoustic emissions(OAE)or cochlear microphonic(CM)responses with severe abnormalities of the auditory brainstem response(ABR).The vestibular branches of the VIII cranial nerve and the structures innervated by it can also be affected.However,the precise lesion sites in the vestibular system are not well characterized in patients with AN.Methods The air-conducted sound(ACS)vestibular-evoked myogenic potentials(VEMPs)and galvanic vestibular stimuli(GVS)-VEMPs were examined in 14 patients with AN.Results On examination of VEMPs(n=14,28 ears),the absent rates of ACS-cervical VEMP(cVEMP),ACS-ocular VEMP(oVEMP),GVS-cVEMP,GVS-oVEMP and caloric test were 92.9%(26/28),85.7%(24/28),67.9%(19/28),53.6%(15/28),and 61.5%(8/13),respectively.Impaired functions of the saccule,inferior vestibular nerve,utricle,superior vestibular nerve,and horizontal semicircular canal were found in 25.0%(7/28),67.9%(19/28),32.1%(9/28),53.6%(15/28)and 61.5%(8/13)patients,respectively.On comparing the elicited VEMPs parameters of AN patients with those of normal controls,both ACS-VEMPs and GVS-VEMPs showed abnormal results in AN patients(such as,lower presence rates,elevated thresholds,prolonged latencies,and decreased amplitudes).Conclusion The study suggested that patients with AN often have concomitant vestibular disorders.Retro-labyrinthine lesions were more frequently observed in this study.GVS-VEMPs combined with ACS-VEMPs may help identify the lesion sites and facilitate detection of areas of vestibular dysfunction in these patients.展开更多
A sustained monaural block of auditory air-conduction model was established in rats through subcutaneous suture in the right ear canal.The gene expression levels of hypothalamic N-methyl-D-aspartate receptor NR1,NR2A,...A sustained monaural block of auditory air-conduction model was established in rats through subcutaneous suture in the right ear canal.The gene expression levels of hypothalamic N-methyl-D-aspartate receptor NR1,NR2A,NR2B and NR2C mRNA in the auditory central nervous system of Sprague-Dawley rats at postnatal 9,23,37 days were determined after an environmental change.Reverse transcription-PCR assay showed that the critical period for the development of NR1,NR2A,and NR2B subunits in the left hypothalamus and NR1-and NR2B-dependent auditory neurons in the right hypothalamus terminated 23 days after the suture in the right ear.The critical period for the development of NR2A subunit-dependent auditory neurons in the right hypothalamus was terminated by postnatal day 37.The results confirmed that N-methyl-D-aspartate receptor subunits in the hypothalamus may be regulated by the auditory environment.展开更多
文摘目的:分析耳科正常青年人气导和骨导短纯音诱发的听性脑干反应(ABR)的特性,比较气骨导短纯音ABR反应阈与纯音听阈的关系,探讨气骨导短纯音ABR反应阈对听阈评估的价值。方法:30例耳科正常青年人(男/女=14/16)分别进行纯音听阈测试、气导和骨导短声及短纯音ABR测试。结果:1气导0.5、1、2、4 k Hz短纯音诱发ABR反应阈分别较对应频率气导纯音听阈高18.41±4.47、13.18±3.63、8.86±5.10、8.64±5.16 d B,骨导0.5、1、2、4 k Hz短纯音诱发ABR反应阈分别较对应频率骨导纯音听阈高14.31±3.98、10.45±4.54、6.82±4.24、8.18±4.77 d B。2气骨导各频率短纯音ABR反应阈的差值分别为5.55±3.42、3.86±4.86、1.36±5.60、1.59±6.05 d B,0.5、1 k Hz气骨导阈值间的差异有统计学意义(P<0.01),2、4k Hz气骨导阈值间的差异无统计学意义(P>0.05)。3气骨导短纯音ABR V波潜伏期均较短声ABR长,其差异有统计学意义(P<0.01),但两者I^V波间期的差异无统计学意义(P>0.05)。结论:气骨导短纯音ABR反应阈可以预测纯音听阈,气骨导短纯音ABR反应阈的差值有助于鉴别听力损失的类型。
基金supported by grants from the National Natural Science Foundation of China(No.81670945,No.81970891,No.81600809,No.81700915)the Shaanxi Major International Cooperative Project of China(No.2020KWZ-019)the Key R&D Projects in Shaanxi Province,China(No.2018SF-189).
文摘Objective Auditory neuropathy(AN)is a unique pattern of hearing loss with preservation of hair cell function.The condition is characterized by the presence of otoacoustic emissions(OAE)or cochlear microphonic(CM)responses with severe abnormalities of the auditory brainstem response(ABR).The vestibular branches of the VIII cranial nerve and the structures innervated by it can also be affected.However,the precise lesion sites in the vestibular system are not well characterized in patients with AN.Methods The air-conducted sound(ACS)vestibular-evoked myogenic potentials(VEMPs)and galvanic vestibular stimuli(GVS)-VEMPs were examined in 14 patients with AN.Results On examination of VEMPs(n=14,28 ears),the absent rates of ACS-cervical VEMP(cVEMP),ACS-ocular VEMP(oVEMP),GVS-cVEMP,GVS-oVEMP and caloric test were 92.9%(26/28),85.7%(24/28),67.9%(19/28),53.6%(15/28),and 61.5%(8/13),respectively.Impaired functions of the saccule,inferior vestibular nerve,utricle,superior vestibular nerve,and horizontal semicircular canal were found in 25.0%(7/28),67.9%(19/28),32.1%(9/28),53.6%(15/28)and 61.5%(8/13)patients,respectively.On comparing the elicited VEMPs parameters of AN patients with those of normal controls,both ACS-VEMPs and GVS-VEMPs showed abnormal results in AN patients(such as,lower presence rates,elevated thresholds,prolonged latencies,and decreased amplitudes).Conclusion The study suggested that patients with AN often have concomitant vestibular disorders.Retro-labyrinthine lesions were more frequently observed in this study.GVS-VEMPs combined with ACS-VEMPs may help identify the lesion sites and facilitate detection of areas of vestibular dysfunction in these patients.
文摘A sustained monaural block of auditory air-conduction model was established in rats through subcutaneous suture in the right ear canal.The gene expression levels of hypothalamic N-methyl-D-aspartate receptor NR1,NR2A,NR2B and NR2C mRNA in the auditory central nervous system of Sprague-Dawley rats at postnatal 9,23,37 days were determined after an environmental change.Reverse transcription-PCR assay showed that the critical period for the development of NR1,NR2A,and NR2B subunits in the left hypothalamus and NR1-and NR2B-dependent auditory neurons in the right hypothalamus terminated 23 days after the suture in the right ear.The critical period for the development of NR2A subunit-dependent auditory neurons in the right hypothalamus was terminated by postnatal day 37.The results confirmed that N-methyl-D-aspartate receptor subunits in the hypothalamus may be regulated by the auditory environment.
