本实验观察了低剂量 X 射线整体和离体照射后对小鼠脾淋巴细胞丝裂原反应的影响。结果表明,X 射线全身照射后小鼠脾脏 T、B 淋巴细胞对刀豆蛋白-A(Con A)和细菌脂多糖(LPS)的反应较对照组增强,尤以75 mGy 组最为明显。在离体照射后,脾...本实验观察了低剂量 X 射线整体和离体照射后对小鼠脾淋巴细胞丝裂原反应的影响。结果表明,X 射线全身照射后小鼠脾脏 T、B 淋巴细胞对刀豆蛋白-A(Con A)和细菌脂多糖(LPS)的反应较对照组增强,尤以75 mGy 组最为明显。在离体照射后,脾淋巴细胞对 Con A 的反应未见明显改变,而对 LPS 反应则低于对照组。提示低剂量 X 射线照射可刺激 T 细胞反应增强。展开更多
Background and Purpose: To perform a retrospective in vivo dosimetry study of 129 total body irradiation (TBI) on leukemia and bone marrow transplant patients treated in our clinic from 2008 to 2011 and to find out if...Background and Purpose: To perform a retrospective in vivo dosimetry study of 129 total body irradiation (TBI) on leukemia and bone marrow transplant patients treated in our clinic from 2008 to 2011 and to find out if there is any indication of the necessity of developing a new efficient TBI approach. Materials and Methods: The in vivo dosimetry data of 129 patients treated with TBI between 2008 and 2011 were retrieved from the database and analyzed. These patients were mostly treated with the regime of a single fraction or 6 fractions with some exceptions of 8-fraction or 2-fraction treatments depending on the protocols that were applied. For every fraction of treatment, 10 pairs of diode dosimeters were used to monitor the doses to the midline of head, neck, arms, mediastinum, left lung, right lung, umbilicus, thigh, knee, and ankle for both AP and PA fields. The doses to the midline of the above body parts were considered to be the average of the AP and PA readings of each diode pair. Dose deviation from the prescribed value for each body part was studied by plotting the histogram of the frequency versus deviation and comparing this with the dose delivered to the midline of the umbilicus to where the dose was prescribed. The correlation of dose deviation to body part thickness was also studied. By studying the dose deviations, we can find the uniformity of general dose distributions for conventional TBI treatments. Results: The retrospective dosimetry study of the 129 TBI patient treatments indicates that for most of the patients treated in our clinic, the doses received by different body parts monitored with in vivo dosimetry were within the window of 10% difference from the prescribed dose. The inhomogeneity of dose on different body parts could be manually improved by using compensators, but the method is cumbersome and time consuming. The dose deviation in many histograms ranging from about ?10% to 10% indicates some incongruity of dose distribution. This could be due to the method of using lead compensato展开更多
文摘本实验观察了低剂量 X 射线整体和离体照射后对小鼠脾淋巴细胞丝裂原反应的影响。结果表明,X 射线全身照射后小鼠脾脏 T、B 淋巴细胞对刀豆蛋白-A(Con A)和细菌脂多糖(LPS)的反应较对照组增强,尤以75 mGy 组最为明显。在离体照射后,脾淋巴细胞对 Con A 的反应未见明显改变,而对 LPS 反应则低于对照组。提示低剂量 X 射线照射可刺激 T 细胞反应增强。
文摘Background and Purpose: To perform a retrospective in vivo dosimetry study of 129 total body irradiation (TBI) on leukemia and bone marrow transplant patients treated in our clinic from 2008 to 2011 and to find out if there is any indication of the necessity of developing a new efficient TBI approach. Materials and Methods: The in vivo dosimetry data of 129 patients treated with TBI between 2008 and 2011 were retrieved from the database and analyzed. These patients were mostly treated with the regime of a single fraction or 6 fractions with some exceptions of 8-fraction or 2-fraction treatments depending on the protocols that were applied. For every fraction of treatment, 10 pairs of diode dosimeters were used to monitor the doses to the midline of head, neck, arms, mediastinum, left lung, right lung, umbilicus, thigh, knee, and ankle for both AP and PA fields. The doses to the midline of the above body parts were considered to be the average of the AP and PA readings of each diode pair. Dose deviation from the prescribed value for each body part was studied by plotting the histogram of the frequency versus deviation and comparing this with the dose delivered to the midline of the umbilicus to where the dose was prescribed. The correlation of dose deviation to body part thickness was also studied. By studying the dose deviations, we can find the uniformity of general dose distributions for conventional TBI treatments. Results: The retrospective dosimetry study of the 129 TBI patient treatments indicates that for most of the patients treated in our clinic, the doses received by different body parts monitored with in vivo dosimetry were within the window of 10% difference from the prescribed dose. The inhomogeneity of dose on different body parts could be manually improved by using compensators, but the method is cumbersome and time consuming. The dose deviation in many histograms ranging from about ?10% to 10% indicates some incongruity of dose distribution. This could be due to the method of using lead compensato
