The aim of the present study was to evaluate whether tissue levels of vitamin B complex and vitamin B12 were altered after crush-induced peripheral nerve injury in an experimental rat model. A total of 80 male Wistar ...The aim of the present study was to evaluate whether tissue levels of vitamin B complex and vitamin B12 were altered after crush-induced peripheral nerve injury in an experimental rat model. A total of 80 male Wistar rats were randomized into one control（n = 8） and six study groups（1, 6, 12, 24 hours, 3, and 7 days after experimental nerve injury; n = 12 for each group）. Crush-induced peripheral nerve injury was performed on the sciatic nerves of rats in six study groups. Tissue samples from the sites of peripheral nerve injury were obtained at 1, 6, 12, 24 hours, 3 and 7 days after experimental nerve injury. Enzyme-linked immunosorbent assay results showed that tissue levels of vitamin B complex and vitamin B12 in the injured sciatic nerve were significantly greater at 1 and 12 hours after experimental nerve injury, while they were significantly lower at 7 days than in control group. Tissue level of vitamin B_（12） in the injured sciatic nerve was significantly lower at 1, 6, 12 and 24 hours than in the control group. These results suggest that tissue levels of vitamin B complex and vitamin B12 vary with progression of crush-induced peripheral nerve injury, and supplementation of these vitamins in the acute period may be beneficial for acceleration of nerve regeneration.展开更多
目的探讨内观认知疗法联合复合维生素B、氯硝西泮治疗酒精依赖患者的临床效果。方法回顾性分析焦作市第四人民医院心理科2018年1月至2019年12月间接收的124例酒精依赖患者的临床资料,按干预方案不同分组,将其中以维持药物(复合维生素B...目的探讨内观认知疗法联合复合维生素B、氯硝西泮治疗酒精依赖患者的临床效果。方法回顾性分析焦作市第四人民医院心理科2018年1月至2019年12月间接收的124例酒精依赖患者的临床资料,按干预方案不同分组,将其中以维持药物(复合维生素B、氯硝西泮)替代干预的59例患者列为对照组;在维持药物替代的同时配合实施内观认知疗法干预的65例患者列为研究组。比较两组干预前后酒精依赖症状宾夕法尼亚酒精渴求量表(Pennsylvania Alcohoi Craving Scale,PACS)、脑电生理活动(P3潜伏期、P3波幅)、领悟社会支持程度量表(perceived social support scale,PSSS)、心理状态(Symptom checklist-90,SCL-90)及干预后6个月内的复饮率。结果干预后两组PACS量表各项评分均降低,研究组低于对照组(P<0.05);干预后两组P3潜伏期缩短、P3波幅升高,研究组均优于对照组(P<0.05);干预后研究组PSSS评分高于对照组、SCL-90评分低于对照组(P<0.05);干预后6个月内,研究组复饮率为18.46%(12/65),低于对照组55.93%(33/59),差异均具有统计学意义(P<0.05)。结论内观认知疗法联合复合维生素B、氯硝西泮治疗酒精依赖患者的临床效果显著,可有效减轻患者酒精依赖症状,改善其脑电生理活动,同时提升其领悟社会支持及心理健康状况,降低复饮率。展开更多
文摘The aim of the present study was to evaluate whether tissue levels of vitamin B complex and vitamin B12 were altered after crush-induced peripheral nerve injury in an experimental rat model. A total of 80 male Wistar rats were randomized into one control（n = 8） and six study groups（1, 6, 12, 24 hours, 3, and 7 days after experimental nerve injury; n = 12 for each group）. Crush-induced peripheral nerve injury was performed on the sciatic nerves of rats in six study groups. Tissue samples from the sites of peripheral nerve injury were obtained at 1, 6, 12, 24 hours, 3 and 7 days after experimental nerve injury. Enzyme-linked immunosorbent assay results showed that tissue levels of vitamin B complex and vitamin B12 in the injured sciatic nerve were significantly greater at 1 and 12 hours after experimental nerve injury, while they were significantly lower at 7 days than in control group. Tissue level of vitamin B_（12） in the injured sciatic nerve was significantly lower at 1, 6, 12 and 24 hours than in the control group. These results suggest that tissue levels of vitamin B complex and vitamin B12 vary with progression of crush-induced peripheral nerve injury, and supplementation of these vitamins in the acute period may be beneficial for acceleration of nerve regeneration.
文摘目的探讨内观认知疗法联合复合维生素B、氯硝西泮治疗酒精依赖患者的临床效果。方法回顾性分析焦作市第四人民医院心理科2018年1月至2019年12月间接收的124例酒精依赖患者的临床资料,按干预方案不同分组,将其中以维持药物(复合维生素B、氯硝西泮)替代干预的59例患者列为对照组;在维持药物替代的同时配合实施内观认知疗法干预的65例患者列为研究组。比较两组干预前后酒精依赖症状宾夕法尼亚酒精渴求量表(Pennsylvania Alcohoi Craving Scale,PACS)、脑电生理活动(P3潜伏期、P3波幅)、领悟社会支持程度量表(perceived social support scale,PSSS)、心理状态(Symptom checklist-90,SCL-90)及干预后6个月内的复饮率。结果干预后两组PACS量表各项评分均降低,研究组低于对照组(P<0.05);干预后两组P3潜伏期缩短、P3波幅升高,研究组均优于对照组(P<0.05);干预后研究组PSSS评分高于对照组、SCL-90评分低于对照组(P<0.05);干预后6个月内,研究组复饮率为18.46%(12/65),低于对照组55.93%(33/59),差异均具有统计学意义(P<0.05)。结论内观认知疗法联合复合维生素B、氯硝西泮治疗酒精依赖患者的临床效果显著,可有效减轻患者酒精依赖症状,改善其脑电生理活动,同时提升其领悟社会支持及心理健康状况,降低复饮率。
