目的:分析大承气汤治疗胃肠功能障碍患者的作用及临床疗效。方法:计算机检索Pub Med、CBMdisc、重庆维普、中国知网和万方数据库,查找有关应用大承气汤治疗胃肠功能障碍的文献,根据文献纳入标准进行筛选,Rev Man 5.2软件对纳入文献进行M...目的:分析大承气汤治疗胃肠功能障碍患者的作用及临床疗效。方法:计算机检索Pub Med、CBMdisc、重庆维普、中国知网和万方数据库,查找有关应用大承气汤治疗胃肠功能障碍的文献,根据文献纳入标准进行筛选,Rev Man 5.2软件对纳入文献进行Meta分析。结果:最终纳入13个研究,共1308名病例。Meta分析结果显示,大承气汤能有效改善胃肠功能障碍患者的临床症状,提高临床疗效,缩短住院时间,其差异有统计学意义。结论:大承气汤对胃肠功能障碍的疗效优于单独常规的西医治疗,在临床上具有良好的应用前景。展开更多
目的:探讨大承气汤治疗大鼠重症急性胰腺炎(SAP)肠功能障碍的可能机制。方法:将54只雄性SD大鼠随机分为假手术组(SO组)、重症急性胰腺炎肠功能障碍组(SAP组)和大承气汤治疗组,每组18只。经胆胰管内加压注射3.5%牛磺胆酸钠0.1 m L/100 g...目的:探讨大承气汤治疗大鼠重症急性胰腺炎(SAP)肠功能障碍的可能机制。方法:将54只雄性SD大鼠随机分为假手术组(SO组)、重症急性胰腺炎肠功能障碍组(SAP组)和大承气汤治疗组,每组18只。经胆胰管内加压注射3.5%牛磺胆酸钠0.1 m L/100 g体质量制备SAP肠功能障碍模型,治疗组在造模前给予10%的大承气汤剂(9.18 g/kg体质量)灌胃1次,SAP组和SO组则灌注等量0.9%氯化钠溶液。每组于造模后3、6、12 h各处死6只大鼠并立即心脏取血,检测血清淀粉酶、脂肪酶水平,酶联免疫吸附试验检测血清5-羟色胺(5-HT)、白介素6(IL-6)含量。同时检测6h时间点各组大鼠距屈氏韧带10 cm空肠、末端回肠及乙状结肠组织中5-HT7R的表达情况。结果:造模后SAP组和治疗组血清淀粉酶、脂肪酶及5-HT水平均明显高于SO组(P<0.05),且每个时间点治疗组均较SAP组显著降低(P<0.05)。与SO组相比,SAP组5-HT7R蛋白及阳性细胞面积表达水平在空肠、末端回肠及乙状结肠均明显增高(P<0.05);与SAP组比较,治疗组各部位5-HT7R蛋白及阳性细胞面积表达均减少(P<0.05)。结论:血清5-HT的增加过度激活5-HT7R可能是SAP发生肠功能障碍的原因之一,而大承气汤可能是通过减少5-HT7R的表达来促进肠功能恢复。展开更多
Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS),the complicated and devastating illness,resulted from various processes of systemic inflammatory response syndrome(SIRS),injure directly or indirectly t...Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS),the complicated and devastating illness,resulted from various processes of systemic inflammatory response syndrome(SIRS),injure directly or indirectly the lung.With the advance of investigations in SIRS and multiple organs disfunction syndrome(MODS),inflammation development and control have been considered to be the important mechanism of ALI/ARDS.The research hotspot is also focused on the inflammatory cells and cytokines.Dachengqi decoction can influence on the functions of inflammatory cells and cytokines,so the strategies of anti-inflammatory treatment on immunoregulation became the key point for prevention and treatment of ALI/ARDS with traditional Chinese medicine.展开更多
Background Traditional Chinese medicine has been used widely for many years in China to treat acute pancreatitis. We have investigated the effects of Dachengqi decoction on intestinal mucosal permeability and outcome ...Background Traditional Chinese medicine has been used widely for many years in China to treat acute pancreatitis. We have investigated the effects of Dachengqi decoction on intestinal mucosal permeability and outcome in patients with severe acute pancreatitis （SAP）. Methods Forty patients with sustained SAP that required admission to the surgical intensive care unit were enrolled prospectively in the study. All of these patients were divided randomly into the Dachengqi decoction group （n=-20） and control group （n=-20） on admission. Intestinal permeability was assessed by measuring absorption of two metabolically inert markers, lactulose （L） and mannitol （M）, which were administered orally. Serum concentrations of endotoxin （lipopolysaccharide, LPS） and the ratio of lactulose to mannitol in urine （L/M） were detected in all patients. Results Compared with those in the control group, urinary L/M ratio decreased significantly in the Dachengqi decoction group on the 7th day after admission （P=0.001）. Also, serum concentrations of LPS were reduced on the 5th and 7th day after admission （P=-0.006, P=0.008, respectively）. Incidence of multiple organ dysfunction syndrome （MODS） and pancreatic infection was significantly lower in the Dachengqi decoction group compared with those in the control group （P=-0.038, P=-0.025, respectively）. Conclusion Dachengqi decoction may promote the recovery of intestinal mucosal permeability and decrease the incidence of MODS and pancreatic infection in patients with SAP.展开更多
文摘目的:分析大承气汤治疗胃肠功能障碍患者的作用及临床疗效。方法:计算机检索Pub Med、CBMdisc、重庆维普、中国知网和万方数据库,查找有关应用大承气汤治疗胃肠功能障碍的文献,根据文献纳入标准进行筛选,Rev Man 5.2软件对纳入文献进行Meta分析。结果:最终纳入13个研究,共1308名病例。Meta分析结果显示,大承气汤能有效改善胃肠功能障碍患者的临床症状,提高临床疗效,缩短住院时间,其差异有统计学意义。结论:大承气汤对胃肠功能障碍的疗效优于单独常规的西医治疗,在临床上具有良好的应用前景。
文摘Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS),the complicated and devastating illness,resulted from various processes of systemic inflammatory response syndrome(SIRS),injure directly or indirectly the lung.With the advance of investigations in SIRS and multiple organs disfunction syndrome(MODS),inflammation development and control have been considered to be the important mechanism of ALI/ARDS.The research hotspot is also focused on the inflammatory cells and cytokines.Dachengqi decoction can influence on the functions of inflammatory cells and cytokines,so the strategies of anti-inflammatory treatment on immunoregulation became the key point for prevention and treatment of ALI/ARDS with traditional Chinese medicine.
文摘Background Traditional Chinese medicine has been used widely for many years in China to treat acute pancreatitis. We have investigated the effects of Dachengqi decoction on intestinal mucosal permeability and outcome in patients with severe acute pancreatitis （SAP）. Methods Forty patients with sustained SAP that required admission to the surgical intensive care unit were enrolled prospectively in the study. All of these patients were divided randomly into the Dachengqi decoction group （n=-20） and control group （n=-20） on admission. Intestinal permeability was assessed by measuring absorption of two metabolically inert markers, lactulose （L） and mannitol （M）, which were administered orally. Serum concentrations of endotoxin （lipopolysaccharide, LPS） and the ratio of lactulose to mannitol in urine （L/M） were detected in all patients. Results Compared with those in the control group, urinary L/M ratio decreased significantly in the Dachengqi decoction group on the 7th day after admission （P=0.001）. Also, serum concentrations of LPS were reduced on the 5th and 7th day after admission （P=-0.006, P=0.008, respectively）. Incidence of multiple organ dysfunction syndrome （MODS） and pancreatic infection was significantly lower in the Dachengqi decoction group compared with those in the control group （P=-0.038, P=-0.025, respectively）. Conclusion Dachengqi decoction may promote the recovery of intestinal mucosal permeability and decrease the incidence of MODS and pancreatic infection in patients with SAP.
