摘要
目的观察足三里穴位注射新斯的明联合大承气汤对脓毒症患者胃肠功能的临床疗效及其机制。方法选择武汉市中心医院2013年1月至2016年6月收治的脓毒症并胃肠功能障碍患者60例,随机分为观察组与对照组,每组30例,对照组给予常规西医治疗,观察组在西医治疗基础上给予足三里穴位注射新斯的明联合大承气汤治疗,比较两组患者临床效果、血清炎症因子及氧化损伤指标。结果两组治疗后APACHEⅡ及SOFA评分均较治疗前改善,其中观察组治疗后APACHEⅡ及SOFA评分明显低于对照组,比较差异有统计学意义(P<0.05)。两组治疗后肠鸣音、腹内压及腹围均较治疗前改善,其中观察组治疗后肠鸣音次数多于对照组,腹内压与腹围观察组小于对照组,组间比较差异有统计学意义(P<0.05)。两组治疗后血清CRP、IL-6水平较治疗前下降,其中观察组治疗后CRP、IL-6水平明显低于对照组,比较差异有统计学意义(P<0.05)。两组治疗后MAD、SOD、GSH-Px、TAO水平均较治疗前改善,其中观察组治疗后MAD水平低于对照组,SOD、GSH、T-AOC水平观察组高于对照组,组间比较差异有统计学意义(P<0.05)。结论足三里穴位注射新斯的明联合大承气汤治疗脓毒症可提高治疗效果,改善胃肠功能,控制机体炎症反应及氧化损失。
Objective：To observe the clinical effect and mechanism of neostigmine injection on Zusanli acupoint combined with Dachengqi Decoction on gastrointestinal function in patients with sepsis. Methods： 60 patients with sepsis complicated with gastrointestinal dysfunction in Wuhan Central Hospital from Jan,2013 to Jun,2016 were selected and randomly divided into observation group and control group with 30 cases in each group. The control group was treated with conventional western medicine therapy. The observation group received neostigmine injection on Zusanli acupoint combined with Dachengqi Decoction on the basis of the control group. The clinical effect,serum inflammatory factors and oxidative damage index were compared between the two groups. Results：APACHEⅡand SOFA scores in the two groups were improved after treatment,and the APACHEⅡand SOFA scores in the observation group were obviously lower than that in the control group,the difference was statistically significant （P〈0.05）. The bowel sounds,intra-abdominal pressure and abdominal perimeter in the two groups were improved after treatment. The number of bowel sounds in the observation group was more than that in the control group and the index on intra-abdominal pressure and abdominal perimeter in the observation group were smaller than that in the control group,the difference was statistically significant （P〈0.05）. The serum CRP and IL-6 levels in the two groups dropped down after treatment and the CRP and IL-6 levels in the observation group was obviously lower than that in the control group,the difference was statistically significant（P〈0.05）. The MAD, SOD,GSH-Px and TAO levels in the two groups were improved after treatment. The MAD level in the observation group was lower than that in the control group after treatment. The SOD,GSH and T-AOC levels in the observa-tion group was higher than that in the control group,the difference was statistically significant（P〈0.05）. Conclu-sion： Zusanli acupoint combined with Dachengqi
出处
《中国中医急症》
2017年第6期1052-1055,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
湖北省武汉市中心医院科研项目(YH16A04)
关键词
足三里穴位注射
新斯的明
大承气汤
脓毒症
胃肠道功能
Zusanli acupoint injection
Neostigmine
Dachengqi Decoction
Sepsis
Gastrointestinal function
