目的探讨听神经病谱系障碍患者的时域间隔感知能力。方法使用美国加州大学尔湾分校开发的时域间隔感知能力测试软件,分别测试成年听力正常者(12例)、感音神经性听力损失者(12例)和听神经病谱系障碍者(15例)能够分辨出刺激声中无声间隔...目的探讨听神经病谱系障碍患者的时域间隔感知能力。方法使用美国加州大学尔湾分校开发的时域间隔感知能力测试软件,分别测试成年听力正常者(12例)、感音神经性听力损失者(12例)和听神经病谱系障碍者(15例)能够分辨出刺激声中无声间隔的最小时长,即时域间隔感知(temporal gap dection,TGD)阈值,比较三组受试者TGD的差异。结果三组受试者左右耳间TGD阈值差异均无统计学意义(P>0.05);听力正常组、感音神经性听力损失组和听神经病谱系障碍组双耳平均TGD阈值分别为3.97±1.12、3.62±1.14、13.72±9.89ms,感音神经性听力损失组TGD阈值与听力正常组差异无统计学意义(P>0.05),而听神经病谱系障碍组TGD阈值显著高于听力正常组和感音神经性听力损失组(P<0.01)。结论听神经病谱系障碍患者听觉系统的时域间隔感知能力下降,且个体差异较大。展开更多
To study the changes of the expression of growth-associated protein-43 (GAP-43) and pathology in temporal infarction of rats photochemically induced and the effects of batroxobin. METHODS: Immunohistochemical techniqu...To study the changes of the expression of growth-associated protein-43 (GAP-43) and pathology in temporal infarction of rats photochemically induced and the effects of batroxobin. METHODS: Immunohistochemical technique and hematoxylin-eosin stain was used to show the changes of the expression of GAP-43 and pathology. RESULTS: In infarction group, GAP-43 expression was markedly increased on the infarction and surrounding tissues at 24 h cerebral infarction. The expression reached peak level at 72 h after cerebral infarction and was decreased at 7 d after cerebral infarction. However, in batroxobin-treated group, GAP-43 expression was increased and the pathological changes were much slight as compared with infarction group. CONCLUSION: The expression of GAP-43 increases in infarction of temporal neocortex and batroxobin promotes the expression of GAP-43 and ameliorates the pathological changes in infarction of temporal neocortex.展开更多
According to the data of precise relevelling and deformation measurement across faults, the temporal and spatial evolution process of crustal deformation field in the source and peripheral regions of the Tangshan ea...According to the data of precise relevelling and deformation measurement across faults, the temporal and spatial evolution process of crustal deformation field in the source and peripheral regions of the Tangshan earthquake (1976, M S=7.8), from 22 years before the earthquake to 9 years after, is described with the method of crustal deforma tion pattern dynamics. The crustal unstable zones first occur in the exterior, and then surround the focal region by contracting from the exterior to the interior, when the focal region appears to be unstable but does not lose stability. After the transient stable state, the second unstable process from the exterior to interior appears, which results in the instability of focal region. 'Deformation gap', 'earthquake gap' and 'locked fault zone' occur before instability, and their spatial distributions overlap, but their occurrence times have little differences. The earthquake occurs after the impending pre slide of the faults in the focal region. The studied results of the evolution process of crustal deformation field are identical with each other and with that of numeric simulation of crustal stress field, which supports the evolution model of seismogenic system with a strong body as its core.展开更多
Yingjiang granite, Hudiequan plagioclase-granite and Longling granite specimens were true-triaxially compressed (σ1>σ2>σ3) till they ruptured. The 8-channel, high-speed microcrack data sampling and analyzing ...Yingjiang granite, Hudiequan plagioclase-granite and Longling granite specimens were true-triaxially compressed (σ1>σ2>σ3) till they ruptured. The 8-channel, high-speed microcrack data sampling and analyzing system were used to preliminarily analyze the temporal and spatial distribution of the microcracks during the rupture-brewing process. Result of our study showed the following: In the primary episode(peak value) of the acoustic emission (AE), many microcracks were developed. In the second episode (relatively stable and of lower value), fewer microcracks were developed. The microcracks developed in the aformentioned 2 episodes all randomly distributed throughout the entire specimens. When stress kept increasing and reached the third episode (the 2nd peak value), the number of microcracks increased again and gradually gaps were formed. The stripe-shaped distribution was only observed in the short period immediately before the main rupturing.展开更多
目的时域间隔感知测试(Temporal gap detection test)主要评估受试者的时间听觉加工能力,本研究主要是对听力正常的儿童和成人进行时域间隔感知测试,探索儿童在生长发育过程中听觉信息处理能力的变化和发展。方法本研究选取20岁~30岁的...目的时域间隔感知测试(Temporal gap detection test)主要评估受试者的时间听觉加工能力,本研究主要是对听力正常的儿童和成人进行时域间隔感知测试,探索儿童在生长发育过程中听觉信息处理能力的变化和发展。方法本研究选取20岁~30岁的听力正常者15例(30耳),4岁~10岁的听力正常儿童70例(140耳),各年龄段10例(20耳),分别对其进行时域间隔感知能力测试,比较各组的时域间隔阈值(TGD thresholds,TGDs)。采用独立样本T检验对男童和女童的TGDs进行比较,以分析性别上的差异。采用独立样本T检验对儿童受试者不同耳别的TGDs进行比较,以分析耳别上的差异。采用Kruskal-Wallis H检验听力正常成人组、7个年龄段儿童组的TGDs的差异,再通过Bonferroni校正法进行组间两两比较。结果①女童(72耳)的时域间隔阈值为6.48±7.49ms,男童(68耳)的时域间隔阈值为5.16±3.14ms,男女性别上无显著性差异(P=0.180>0.05)。②左耳(70耳)的时域间隔阈值为5.74±4.91ms,右耳(70耳)的时域间隔阈值为5.93±6.63ms,左右耳别上无显著性差异(P=0.884>0.05)。③听力正常成人组的时域间隔阈值为3.94±1.44ms,4岁儿童组的时域间隔阈值为13.06±12.52ms,5岁儿童组的时域间隔阈值为6.95±2.71ms,6岁儿童组的时域间隔阈值为4.55±1.06ms,7岁儿童组的时域间隔阈值为4.52±1.90ms,8岁儿童组的时域间隔阈值为4.12±1.80ms,9岁儿童组的时域间隔阈值为3.74±1.17ms,10岁儿童组的时域间隔阈值为3.92±1.65ms。④年龄4岁和5岁儿童组时域间隔阈值显著高于听力正常成人组和年龄≥6岁各儿童组(P<0.001)。⑤听力正常成人组和年龄≥6岁儿童各组相比无显著性差异(P>0.05)。⑥随着年龄增长,儿童组的时域间隔阈值呈下降趋势,6岁已接近成人水平。结论时域间隔感知能力测试在一定程度上反映了中枢听觉系统的信息处理能力,年龄≥6岁儿童的时域间隔阈值与成人相比无�展开更多
文摘目的探讨听神经病谱系障碍患者的时域间隔感知能力。方法使用美国加州大学尔湾分校开发的时域间隔感知能力测试软件,分别测试成年听力正常者(12例)、感音神经性听力损失者(12例)和听神经病谱系障碍者(15例)能够分辨出刺激声中无声间隔的最小时长,即时域间隔感知(temporal gap dection,TGD)阈值,比较三组受试者TGD的差异。结果三组受试者左右耳间TGD阈值差异均无统计学意义(P>0.05);听力正常组、感音神经性听力损失组和听神经病谱系障碍组双耳平均TGD阈值分别为3.97±1.12、3.62±1.14、13.72±9.89ms,感音神经性听力损失组TGD阈值与听力正常组差异无统计学意义(P>0.05),而听神经病谱系障碍组TGD阈值显著高于听力正常组和感音神经性听力损失组(P<0.01)。结论听神经病谱系障碍患者听觉系统的时域间隔感知能力下降,且个体差异较大。
文摘To study the changes of the expression of growth-associated protein-43 (GAP-43) and pathology in temporal infarction of rats photochemically induced and the effects of batroxobin. METHODS: Immunohistochemical technique and hematoxylin-eosin stain was used to show the changes of the expression of GAP-43 and pathology. RESULTS: In infarction group, GAP-43 expression was markedly increased on the infarction and surrounding tissues at 24 h cerebral infarction. The expression reached peak level at 72 h after cerebral infarction and was decreased at 7 d after cerebral infarction. However, in batroxobin-treated group, GAP-43 expression was increased and the pathological changes were much slight as compared with infarction group. CONCLUSION: The expression of GAP-43 increases in infarction of temporal neocortex and batroxobin promotes the expression of GAP-43 and ameliorates the pathological changes in infarction of temporal neocortex.
文摘According to the data of precise relevelling and deformation measurement across faults, the temporal and spatial evolution process of crustal deformation field in the source and peripheral regions of the Tangshan earthquake (1976, M S=7.8), from 22 years before the earthquake to 9 years after, is described with the method of crustal deforma tion pattern dynamics. The crustal unstable zones first occur in the exterior, and then surround the focal region by contracting from the exterior to the interior, when the focal region appears to be unstable but does not lose stability. After the transient stable state, the second unstable process from the exterior to interior appears, which results in the instability of focal region. 'Deformation gap', 'earthquake gap' and 'locked fault zone' occur before instability, and their spatial distributions overlap, but their occurrence times have little differences. The earthquake occurs after the impending pre slide of the faults in the focal region. The studied results of the evolution process of crustal deformation field are identical with each other and with that of numeric simulation of crustal stress field, which supports the evolution model of seismogenic system with a strong body as its core.
文摘Yingjiang granite, Hudiequan plagioclase-granite and Longling granite specimens were true-triaxially compressed (σ1>σ2>σ3) till they ruptured. The 8-channel, high-speed microcrack data sampling and analyzing system were used to preliminarily analyze the temporal and spatial distribution of the microcracks during the rupture-brewing process. Result of our study showed the following: In the primary episode(peak value) of the acoustic emission (AE), many microcracks were developed. In the second episode (relatively stable and of lower value), fewer microcracks were developed. The microcracks developed in the aformentioned 2 episodes all randomly distributed throughout the entire specimens. When stress kept increasing and reached the third episode (the 2nd peak value), the number of microcracks increased again and gradually gaps were formed. The stripe-shaped distribution was only observed in the short period immediately before the main rupturing.
