目的:建立快速检测保健食品中非法添加的西地那非、那红地那非、他达拉非、氨基他达拉非、伪伐地那非、那莫西地那非、二乙胺他达拉非7种5型磷酸二酯酶抑制剂的离子迁移谱方法。方法:采用离子迁移谱正离子模式检测西地那非、那红地那非...目的:建立快速检测保健食品中非法添加的西地那非、那红地那非、他达拉非、氨基他达拉非、伪伐地那非、那莫西地那非、二乙胺他达拉非7种5型磷酸二酯酶抑制剂的离子迁移谱方法。方法:采用离子迁移谱正离子模式检测西地那非、那红地那非、他达拉非、氨基他达拉非、伪伐地那非、那莫西地那非、二乙胺他达拉非7种5型磷酸二酯酶抑制剂,离子源电压为2.5 k V,迁移管电压为7.5 k V,进气口温度和迁移管温度均为180℃。利用所建立方法对20批市售缓解体力疲劳类保健食品进行非法添加筛查,并通过LC-MS进行确认。结果:7种5型磷酸二酯酶抑制剂迁移时间在13.8~16.2 ms之间,检出限为0.05~2μg·m L^(-1)。20批市售样品中13批检出西地那非,2批检出他达拉非,2批同时检出西地那非与他达拉非,与LC-MS检测结果一致。结论:离子迁移谱检测方法快速、灵敏,可以作为缓解体力疲劳类保健食品中非法添加的西地那非、那红地那非、他达拉非、氨基他达拉非、伪伐地那非、那莫西地那非、二乙胺他达拉非7种5型磷酸二酯酶抑制剂的快速初筛方法。展开更多
Aim： To investigate how erectile dysfunction （ED） medications affect morning erection in patients with ED and how they respond to the return of morning erection. Methods： This study was conducted in 120 patients w...Aim： To investigate how erectile dysfunction （ED） medications affect morning erection in patients with ED and how they respond to the return of morning erection. Methods： This study was conducted in 120 patients who experienced successful intercourse with either tadalafil or sildenafil. Using a random face-to-face interview and a questionnaire （about the quality and number of days getting morning erection after using the two medications）, the impact of the medications on the morning erections was investigated, and the participants were asked about their feelings on regaining morning erection. Results： Of the respondents, 81% （68% of those with sildenafil and 99% of those with tadalafil） experienced morning erections after taking an oral ED medication. The men who took tadalafil mainly for 2 days with one dose, while those who took sildenafil experienced morning erections mainly for 1 day. The major sentiment upon regaining a morning erection was, ＂having more confidence as a man＂ （74%）. Among the 96 respondents who experienced morning erections with tadalafil, 52% preferred tadalafil over sildenafil, not only because of freedom from concerns about a specific time to have relations, but also regaining morning erection. Conclusion： Regaining a morning erection affects the recovery of confidence as a man and influences the preference for tadalafil over sildenafil.展开更多
文摘目的:建立快速检测保健食品中非法添加的西地那非、那红地那非、他达拉非、氨基他达拉非、伪伐地那非、那莫西地那非、二乙胺他达拉非7种5型磷酸二酯酶抑制剂的离子迁移谱方法。方法:采用离子迁移谱正离子模式检测西地那非、那红地那非、他达拉非、氨基他达拉非、伪伐地那非、那莫西地那非、二乙胺他达拉非7种5型磷酸二酯酶抑制剂,离子源电压为2.5 k V,迁移管电压为7.5 k V,进气口温度和迁移管温度均为180℃。利用所建立方法对20批市售缓解体力疲劳类保健食品进行非法添加筛查,并通过LC-MS进行确认。结果:7种5型磷酸二酯酶抑制剂迁移时间在13.8~16.2 ms之间,检出限为0.05~2μg·m L^(-1)。20批市售样品中13批检出西地那非,2批检出他达拉非,2批同时检出西地那非与他达拉非,与LC-MS检测结果一致。结论:离子迁移谱检测方法快速、灵敏,可以作为缓解体力疲劳类保健食品中非法添加的西地那非、那红地那非、他达拉非、氨基他达拉非、伪伐地那非、那莫西地那非、二乙胺他达拉非7种5型磷酸二酯酶抑制剂的快速初筛方法。
文摘Aim： To investigate how erectile dysfunction （ED） medications affect morning erection in patients with ED and how they respond to the return of morning erection. Methods： This study was conducted in 120 patients who experienced successful intercourse with either tadalafil or sildenafil. Using a random face-to-face interview and a questionnaire （about the quality and number of days getting morning erection after using the two medications）, the impact of the medications on the morning erections was investigated, and the participants were asked about their feelings on regaining morning erection. Results： Of the respondents, 81% （68% of those with sildenafil and 99% of those with tadalafil） experienced morning erections after taking an oral ED medication. The men who took tadalafil mainly for 2 days with one dose, while those who took sildenafil experienced morning erections mainly for 1 day. The major sentiment upon regaining a morning erection was, ＂having more confidence as a man＂ （74%）. Among the 96 respondents who experienced morning erections with tadalafil, 52% preferred tadalafil over sildenafil, not only because of freedom from concerns about a specific time to have relations, but also regaining morning erection. Conclusion： Regaining a morning erection affects the recovery of confidence as a man and influences the preference for tadalafil over sildenafil.
