TSH受体抗体(TRAb)是Graves病的致病性抗体。TRAb水平与Graves病的严重程度有关,并且是Graves病复发的预测因子。但是目前仍不清楚哪些因素可能影响TRAb与甲状腺激素水平和Graves病复发风险的相关性。2018年12月The Journal of Clinical...TSH受体抗体(TRAb)是Graves病的致病性抗体。TRAb水平与Graves病的严重程度有关,并且是Graves病复发的预测因子。但是目前仍不清楚哪些因素可能影响TRAb与甲状腺激素水平和Graves病复发风险的相关性。2018年12月The Journal of Clinical Endocrinology & Metabolism杂志在线发表了1篇文章[Bano A, Gan E, Addison C, et al. Age may influence the impact of TRAbs on thyroid function and relapse-risk in patients with Graves′ disease. J Clin Endocrinol Metab, 2019,104(5):1378-1385. DOI: 10.1210/jc.2018-01738]。在获得原文杂志授权同意后,对该文进行中文编译。该文研究了Graves病患者诊断时TRAb水平与甲状腺激素和疾病复发风险之间的相关性,以及影响这种相关性的潜在因素。结果显示,基线TRAb水平与血清甲状腺激素水平和Graves病复发风险呈正相关;年龄会影响其相关性,但性别、种族、吸烟和甲状腺过氧化物酶抗体水平不会影响二者的关系。该研究表明就甲状腺激素水平和Graves病复发风险而言,诊断时的TRAb水平在年轻患者中可能比在老年患者中具有更好的预测价值。展开更多
Objective:To investigate the clinical significance of serum thyroid stimulating hormone(TSH) receptor antibody(TRAb) levels in pregnant women with Graves'disease,on neonatal hyperthyroidism. Methods:The clinical d...Objective:To investigate the clinical significance of serum thyroid stimulating hormone(TSH) receptor antibody(TRAb) levels in pregnant women with Graves'disease,on neonatal hyperthyroidism. Methods:The clinical data of 68 pregnant women with Graves' disease and their newborns were retrospectively analyzed.Testing indicators included thyroid function tests and TRAb levels during pregnancy,at delivery,and within 2 weeks after birth.The serum TRAb and T_3,T_4,Free T_3,Free T_4,TSH levels were detected by radio receptor assay(RRA) and electrical chemiluminescence immunoassay(ECLIA),respectively. Results:The results showed that serum TRAb levels of the third trimester of pregnancy was positively correlated with that of the umbilical vein(n = 68,r= 0.8494,P<0.01),and that of the newborns(n = 68, r=0.8286,P<0.01).The incidence of neonatal hyperthyroidism was 11.8%(8/68).The serum TRAb levels in the 8 neonates with hyperthyroidism within 2 weeks after birth were 3 times higher than those in the normal neonates.Of these 8 neonates,2 had 15 times higher serum TRAb levels than those of normal neonates within 2 weeks after birth.The thyroid function and TRAb levels of these 2 neonates were still abnormal 6 months later. Conclusions:The risk of hyperthyroidism in newborn whose mother's TRAb levels were high in the third trimester of pregnancy was increased.This study suggests a significant correlation between TRAb levels in pregnant women with Graves' disease and the severity of neonatal hyperthyroidism.展开更多
文摘TSH受体抗体(TRAb)是Graves病的致病性抗体。TRAb水平与Graves病的严重程度有关,并且是Graves病复发的预测因子。但是目前仍不清楚哪些因素可能影响TRAb与甲状腺激素水平和Graves病复发风险的相关性。2018年12月The Journal of Clinical Endocrinology & Metabolism杂志在线发表了1篇文章[Bano A, Gan E, Addison C, et al. Age may influence the impact of TRAbs on thyroid function and relapse-risk in patients with Graves′ disease. J Clin Endocrinol Metab, 2019,104(5):1378-1385. DOI: 10.1210/jc.2018-01738]。在获得原文杂志授权同意后,对该文进行中文编译。该文研究了Graves病患者诊断时TRAb水平与甲状腺激素和疾病复发风险之间的相关性,以及影响这种相关性的潜在因素。结果显示,基线TRAb水平与血清甲状腺激素水平和Graves病复发风险呈正相关;年龄会影响其相关性,但性别、种族、吸烟和甲状腺过氧化物酶抗体水平不会影响二者的关系。该研究表明就甲状腺激素水平和Graves病复发风险而言,诊断时的TRAb水平在年轻患者中可能比在老年患者中具有更好的预测价值。
文摘Objective:To investigate the clinical significance of serum thyroid stimulating hormone(TSH) receptor antibody(TRAb) levels in pregnant women with Graves'disease,on neonatal hyperthyroidism. Methods:The clinical data of 68 pregnant women with Graves' disease and their newborns were retrospectively analyzed.Testing indicators included thyroid function tests and TRAb levels during pregnancy,at delivery,and within 2 weeks after birth.The serum TRAb and T_3,T_4,Free T_3,Free T_4,TSH levels were detected by radio receptor assay(RRA) and electrical chemiluminescence immunoassay(ECLIA),respectively. Results:The results showed that serum TRAb levels of the third trimester of pregnancy was positively correlated with that of the umbilical vein(n = 68,r= 0.8494,P<0.01),and that of the newborns(n = 68, r=0.8286,P<0.01).The incidence of neonatal hyperthyroidism was 11.8%(8/68).The serum TRAb levels in the 8 neonates with hyperthyroidism within 2 weeks after birth were 3 times higher than those in the normal neonates.Of these 8 neonates,2 had 15 times higher serum TRAb levels than those of normal neonates within 2 weeks after birth.The thyroid function and TRAb levels of these 2 neonates were still abnormal 6 months later. Conclusions:The risk of hyperthyroidism in newborn whose mother's TRAb levels were high in the third trimester of pregnancy was increased.This study suggests a significant correlation between TRAb levels in pregnant women with Graves' disease and the severity of neonatal hyperthyroidism.
