摘要
96例Graves病（GD）甲亢患者抗甲状腺药物（ATD）治疗一年半观察疗效。测定血清促甲状腺激素受体抗体（TRAb）水平、血清总碘含量和外周血单个核细胞表面CD80mRNA表达。多因素条件logistic回归分析各危险因素，结果显示GD患者TRAb水平增高、GD阳性家族史、CD80表达量增高、血清总碘含量增高、发病年龄早可能是导致ATD治疗后复发的危险因素。
A total of 96 patients with Graves＇ disease （GD） were followed for one and half years to observe the effect of antithyroid drugs （ATD）treatment. Serum TRAb, total iodine concentration and CDS0 mRNA expression of peripheral blood monouclear ceils were measured. Logistics regression analysis was conducted with the combination of above parameters. Those GD patients with high level of TRAb, positive family history of GD, increased expression of CD80 and early age of onset were more inclined to relapse after ATD treatment.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2009年第2期184-185,共2页
Chinese Journal of Endocrinology and Metabolism
基金
基金项目：2007年湖北省科技攻关（2006AA412C29）
