Objectives:To discuss the mechanism of Sheng Yang San Huo decoction on diabetic peripheral neuropathy using the network pharmacology method.Methods:The BATMAN-TCM database,TCM-ID database,Chinese Natural Product Chemi...Objectives:To discuss the mechanism of Sheng Yang San Huo decoction on diabetic peripheral neuropathy using the network pharmacology method.Methods:The BATMAN-TCM database,TCM-ID database,Chinese Natural Product Chemical Composition Database,and TCMIP database were employed to screen the chemical active ingredients of each herb in Sheng Yang San Huo decoction based on the“Libinsky Drug Rules”.SwissTargetPrediction was used to screen effective action targets for each herb in the prescription.Additionally,Cytoscape 3.7.0 was utilized to construct a“drug-target”network.GeneCards,OMIM,and MaLaCards databases were utilized to gather targets related to diabetic peripheral neuropathy.VENNY 2.1 online platform was employed to match drug and disease targets,draw a Venn diagram,and construct a“drug-active compounds-common target”network using Cytoscape 3.7.0.gene ontology biological process analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis for the targets were conducted using the DAVID 6.8 database.Enrichment analysis results were visualized using the OmicShareTool online platform.Molecular docking was performed using CB-Dock2.Results:Following screening,a total of 217 active compounds and 132 potential targets were identified in Sheng Yang San Huo decoction.The effects are primarily enriched in pathways such as Lipid and Atherosclerosis,AGE-RAGE signaling pathway in diabetic complications,and the IL-17 signaling pathway.The binding energy of the key active ingredients to the core protein targets of DPN was favorable.Conclusion:The study reveals the characteristics of multiple targets and pathways of Sheng Yang San Huo decoction,providing new insights for the clinical application of this prescription.展开更多
Da Sheng Bian,a significant work on obstetrics and gynecology that emerged in the early Qing Dynasty,was initially published as“A Treatise on Midwifery”in 1842 by William Lockhart,a British missionary to China.In 18...Da Sheng Bian,a significant work on obstetrics and gynecology that emerged in the early Qing Dynasty,was initially published as“A Treatise on Midwifery”in 1842 by William Lockhart,a British missionary to China.In 1894,John G.Kerr,an American missionary,translated the text as“The Tat Shang Pin”.This paper conducts a comparative study of the two English translations using a self-constructed English-Chinese parallel corpus of Da Sheng Bian.The study explores the translation styles of the two translators by examining the token-types ratio and frequency at the lexical level,mean sentence length at the syntactic level,and the use of conjunctions at the discourse level.The observed differences in translation styles between the two translations are analyzed in relation to the translators’backgrounds and translation strategies.展开更多
基金the 2022 Chongqing Natural Science Foundation(Postdoctoral Project)(CSTB2022NSCQ-BHX0690)the 2022 Chongqing Postdoctoral Innovation Talent Support Plan(CQBX202212)the 2023 Chongqing Science and Health Joint Medical Research Project(2023QNXM002).
文摘Objectives:To discuss the mechanism of Sheng Yang San Huo decoction on diabetic peripheral neuropathy using the network pharmacology method.Methods:The BATMAN-TCM database,TCM-ID database,Chinese Natural Product Chemical Composition Database,and TCMIP database were employed to screen the chemical active ingredients of each herb in Sheng Yang San Huo decoction based on the“Libinsky Drug Rules”.SwissTargetPrediction was used to screen effective action targets for each herb in the prescription.Additionally,Cytoscape 3.7.0 was utilized to construct a“drug-target”network.GeneCards,OMIM,and MaLaCards databases were utilized to gather targets related to diabetic peripheral neuropathy.VENNY 2.1 online platform was employed to match drug and disease targets,draw a Venn diagram,and construct a“drug-active compounds-common target”network using Cytoscape 3.7.0.gene ontology biological process analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis for the targets were conducted using the DAVID 6.8 database.Enrichment analysis results were visualized using the OmicShareTool online platform.Molecular docking was performed using CB-Dock2.Results:Following screening,a total of 217 active compounds and 132 potential targets were identified in Sheng Yang San Huo decoction.The effects are primarily enriched in pathways such as Lipid and Atherosclerosis,AGE-RAGE signaling pathway in diabetic complications,and the IL-17 signaling pathway.The binding energy of the key active ingredients to the core protein targets of DPN was favorable.Conclusion:The study reveals the characteristics of multiple targets and pathways of Sheng Yang San Huo decoction,providing new insights for the clinical application of this prescription.
基金Phased research results of“The Research and Practice of International Communication Ability Training of English Students”(Approval No.HNJG-2022-0678)。
文摘Da Sheng Bian,a significant work on obstetrics and gynecology that emerged in the early Qing Dynasty,was initially published as“A Treatise on Midwifery”in 1842 by William Lockhart,a British missionary to China.In 1894,John G.Kerr,an American missionary,translated the text as“The Tat Shang Pin”.This paper conducts a comparative study of the two English translations using a self-constructed English-Chinese parallel corpus of Da Sheng Bian.The study explores the translation styles of the two translators by examining the token-types ratio and frequency at the lexical level,mean sentence length at the syntactic level,and the use of conjunctions at the discourse level.The observed differences in translation styles between the two translations are analyzed in relation to the translators’backgrounds and translation strategies.
