目的探讨常规超声联合血清甲状腺球蛋白抗体(anti-thyroglobulin antibodies,TGAb)水平对桥本甲状腺炎的诊断价值。方法选取2021年3月至2022年10月聊城市第三人民医院收治的86例疑似桥本甲状腺炎患者[男40例、女46例,年龄(41.67±3....目的探讨常规超声联合血清甲状腺球蛋白抗体(anti-thyroglobulin antibodies,TGAb)水平对桥本甲状腺炎的诊断价值。方法选取2021年3月至2022年10月聊城市第三人民医院收治的86例疑似桥本甲状腺炎患者[男40例、女46例,年龄(41.67±3.35)岁,统计病理学诊断结果(经病理诊断为桥本甲状腺炎67例,非桥本甲状腺炎19例)],根据病理诊断结果分为桥本甲状腺炎组和非桥本甲状腺炎组,均行常规超声诊断桥本甲状腺炎。检测患者血清TGAb水平,比较常规超声、血清TGAb水平及联合诊断桥本甲状腺炎的效能。采用logistic回归进行多因素分析,以受试者工作特征曲线(receiver operating characteristic curve,ROC)分析TGAb水平、豹纹状对桥本甲状腺炎的诊断价值。结果桥本甲状腺炎组常规超声中豹纹状及TGAb水平高于非桥本甲状腺炎组[53.73%(36/67)比26.32%(5/19)、(83.25±8.14)IU/ml比(46.34±6.27)IU/ml,均P<0.05]。多因素分析结果显示,TGAb水平与患者桥本甲状腺炎诊断相关(OR=3.615,P<0.05)。常规超声、TGAb水平及联合诊断桥本甲状腺炎的曲线下面积(area under the curve,AUC)分别为0.756、0.706、0.838,特异度分别为57.9%、63.2%、84.2%,灵敏度分别为86.6%、71.6%、89.6%,常规超声联合TGAb水平诊断效能优于单独检查。结论常规超声、血清TGAb水平对桥本甲状腺炎均有一定的诊断价值,但联合的诊断价值更高,可为临床诊断提供可靠的依据。展开更多
This study was to explore the optimal threshold of thyroid-stimulating hormone(TSH)-stimulated serum thyroglobulin(s-Tg) for patients who were to receive18F-fluorodeoxyglucose(18F-FDG) PET/CT scan owing to clinical su...This study was to explore the optimal threshold of thyroid-stimulating hormone(TSH)-stimulated serum thyroglobulin(s-Tg) for patients who were to receive18F-fluorodeoxyglucose(18F-FDG) PET/CT scan owing to clinical suspicion of differentiated thyroid cancer(DTC) recurrence but negative post-therapeutic 131I whole-body scan(131I-WBS). A total of 60 qualified patients underwent PET/CT scanning from October 2010 to July 2014. The receiver operating characteristic(ROC) curve analyses showed that s-Tg levels over 49 μg/L led to the highest diagnostic accuracy of PET/CT to detect recurrence, with a sensitivity of 89.5% and a specificity of 90.9%. Besides, bivariate correlation analysis showed positive correlation between s-Tg levels and the maximum standardized uptake values(SUVmax) of18F-FDG in patients with positive PET/CT scanning, suggesting a significant influence of TSH both on Tg release and uptake of18F-FDG. So, positive PET/CT imaging is expected when patients have negative 131I-WBS but s-Tg levels over 49 μg/L.展开更多
文摘目的探讨常规超声联合血清甲状腺球蛋白抗体(anti-thyroglobulin antibodies,TGAb)水平对桥本甲状腺炎的诊断价值。方法选取2021年3月至2022年10月聊城市第三人民医院收治的86例疑似桥本甲状腺炎患者[男40例、女46例,年龄(41.67±3.35)岁,统计病理学诊断结果(经病理诊断为桥本甲状腺炎67例,非桥本甲状腺炎19例)],根据病理诊断结果分为桥本甲状腺炎组和非桥本甲状腺炎组,均行常规超声诊断桥本甲状腺炎。检测患者血清TGAb水平,比较常规超声、血清TGAb水平及联合诊断桥本甲状腺炎的效能。采用logistic回归进行多因素分析,以受试者工作特征曲线(receiver operating characteristic curve,ROC)分析TGAb水平、豹纹状对桥本甲状腺炎的诊断价值。结果桥本甲状腺炎组常规超声中豹纹状及TGAb水平高于非桥本甲状腺炎组[53.73%(36/67)比26.32%(5/19)、(83.25±8.14)IU/ml比(46.34±6.27)IU/ml,均P<0.05]。多因素分析结果显示,TGAb水平与患者桥本甲状腺炎诊断相关(OR=3.615,P<0.05)。常规超声、TGAb水平及联合诊断桥本甲状腺炎的曲线下面积(area under the curve,AUC)分别为0.756、0.706、0.838,特异度分别为57.9%、63.2%、84.2%,灵敏度分别为86.6%、71.6%、89.6%,常规超声联合TGAb水平诊断效能优于单独检查。结论常规超声、血清TGAb水平对桥本甲状腺炎均有一定的诊断价值,但联合的诊断价值更高,可为临床诊断提供可靠的依据。
基金supported by Shanghai Municipal Commission of Health and Family Planning of China(No.20134339)
文摘This study was to explore the optimal threshold of thyroid-stimulating hormone(TSH)-stimulated serum thyroglobulin(s-Tg) for patients who were to receive18F-fluorodeoxyglucose(18F-FDG) PET/CT scan owing to clinical suspicion of differentiated thyroid cancer(DTC) recurrence but negative post-therapeutic 131I whole-body scan(131I-WBS). A total of 60 qualified patients underwent PET/CT scanning from October 2010 to July 2014. The receiver operating characteristic(ROC) curve analyses showed that s-Tg levels over 49 μg/L led to the highest diagnostic accuracy of PET/CT to detect recurrence, with a sensitivity of 89.5% and a specificity of 90.9%. Besides, bivariate correlation analysis showed positive correlation between s-Tg levels and the maximum standardized uptake values(SUVmax) of18F-FDG in patients with positive PET/CT scanning, suggesting a significant influence of TSH both on Tg release and uptake of18F-FDG. So, positive PET/CT imaging is expected when patients have negative 131I-WBS but s-Tg levels over 49 μg/L.
