摘要
目的:探讨血清甲状腺球蛋白水平对术后分化型甲状腺癌患者预后的临床价值。方法:选择2012年5月~2015年5月期间某院接收的分化型甲状腺癌患者62例作为研究对象,均行甲状腺全切除治疗,术后12个月复诊测定血清甲状腺球蛋白水平,评估不同临床病理特征甲状腺球蛋白水平及不同甲状腺球蛋白水平的无进展生存期。结果:淋巴结转移及远处转移患者血清甲状腺球蛋白水平明显提升,且显著高于非转移患者(P<0.05);血清甲状腺球蛋白临界值为14.3μg/L,灵敏度为85.12%,特异度为84.05%;血清甲状腺球蛋白≥14.3μg/L疾病进展或死亡率为82.61%,而不足14.3μg/L疾病进展或死亡率为23.08%,差异显著(P<0.05)。结论:针对行甲状腺全切除治疗分化型甲状腺癌患者术后检测血清甲状腺球蛋白水平可作为评估患者预后的可靠指标,可评估其是否发生淋巴结转移及无进展生存期。
Objective:To investigate the clinical value of serum thyroglobulin level in the prognosis of patients with differentiated thyroid cancer after operation.Methods:62 patients with differentiated thyroid cancer in a hospital from May 2012 to May 2015 were selected and treated with total thyroidectomy.Serum thyroglobulin levels were measured at 12 months after operation,and the progression-free survival of different thyroid globulin levels and thyroid globulin levels in different clinicopathological features were evaluated.Results:The serum thyroglobulin levels in patients with lymph node metastasis and distant metastasis were significantly higher than those in patients without metastasis(P<0.05);The threshold value of serum thyroglobulin was 14.3 ug/L,the sensitivity was 85.12%,and the specificity was 84.05%.The progression or mortality rate of serum thyroglobulin≥14.3 ug/L was 82.61%,that of less than 14.3 ug/L was 23.08%.The difference was significant(P<0.05).Conclusion:Detection of serum thyroglobulin levels after total thyroidectomy for differentiated thyroid cancer can be used as a reliable prognostic indicator to evaluate the prognosis of patients,and whether lymph node metastasis and progression-free survival can be evaluated.
作者
张永博
Zhang Yongbo(Department of Hematology,Hongli Hospital,Henan Province,Xinxiang 453400)
出处
《数理医药学杂志》
2021年第2期179-180,共2页
Journal of Mathematical Medicine
