Extracts of Gentianaceae herbs have been widely used as food additives,teas,or medicinal remedies for various human diseases and disorders.Iridoids,secoiridoids,and analogs glycosides,mainly include gentiopicroside,sw...Extracts of Gentianaceae herbs have been widely used as food additives,teas,or medicinal remedies for various human diseases and disorders.Iridoids,secoiridoids,and analogs glycosides,mainly include gentiopicroside,sweroside,swertiamarin,and loganic acid,are the characteristic compounds found in the Gentianaceae plants.The uses of the medicinal herbs containing these secoiridoids have been described in Chinese Materia Medica.Herbal extracts containing iridoids,secoiridoids,and analogs could exert protective effects in multiple human tissues and cells.Some of these medicinal herbs have been studied using modern pharmacological means.The results indicate that they have analgesic,liver protective,anti-inflammatory,antiallergic,anti-pathogeny,and anti-bacterial functions.This review was aimed to summarize the use of Gentianaceae herbs for disease treatments and pharmacokinetic characteristics of the active compounds.In so doing,we hope to demonstrate that Gentianaceae herbs and bioactive compounds in them may have abilities to affect inflammation,hepatic metabolism and cell signaling.In addition,we would like to bring this to the attention of the field about the use and study of compounds derived from Gentianaceae herbs.展开更多
From the roots ofPicrorhiza scrophulariiflora, two new secoifidoid glycosides, named picrosecosides Ⅰ and Ⅱ （1, 2） have been isolated. Their structures were elucidated on the basis of chemical and spectropic evide...From the roots ofPicrorhiza scrophulariiflora, two new secoifidoid glycosides, named picrosecosides Ⅰ and Ⅱ （1, 2） have been isolated. Their structures were elucidated on the basis of chemical and spectropic evidences.展开更多
Objective Establishing a fingerprint method to identify the characteristic chemicals in the roots of Gentiana macrophylla and evaluate their quality. Methods RP-HPLC was developed for fingerprint analysis and determin...Objective Establishing a fingerprint method to identify the characteristic chemicals in the roots of Gentiana macrophylla and evaluate their quality. Methods RP-HPLC was developed for fingerprint analysis and determination of four ingredients in G. macrophylla roots from different sources. LC-ESI-TOF-MS was employed to identify the chromatographic peaks of the fingerprint. Results Five common peaks were identified by comparing their retention time with reference secoiridoid glucosides. Eight major peaks in chromatographic fingerprint were analyzed by on-line LC-ESI-TOF-MS. Four secoiridoid glucosides were identified based on their MS data. Conclusion The method is specific and could be served for the quality identification and comprehensive evaluation of G. macrophylla.展开更多
Two new phenylethanoid glycosides,named scroside H（1）,scroside I（2）,and a new secoiridoid glycoside,named picrogentioside I（3）,have been isolated from the underground parts of Picrorhiza scrophulariiflora.Their ...Two new phenylethanoid glycosides,named scroside H（1）,scroside I（2）,and a new secoiridoid glycoside,named picrogentioside I（3）,have been isolated from the underground parts of Picrorhiza scrophulariiflora.Their structures were elucidated on the basis of spectroscopic evidence.展开更多
基金support from Research project of the National Natural Science Foundation of China(No.81873090,81374064)the Fundamental Research Funds for the Central Universities,South-Central University for Nationalities(CZP20002)。
文摘Extracts of Gentianaceae herbs have been widely used as food additives,teas,or medicinal remedies for various human diseases and disorders.Iridoids,secoiridoids,and analogs glycosides,mainly include gentiopicroside,sweroside,swertiamarin,and loganic acid,are the characteristic compounds found in the Gentianaceae plants.The uses of the medicinal herbs containing these secoiridoids have been described in Chinese Materia Medica.Herbal extracts containing iridoids,secoiridoids,and analogs could exert protective effects in multiple human tissues and cells.Some of these medicinal herbs have been studied using modern pharmacological means.The results indicate that they have analgesic,liver protective,anti-inflammatory,antiallergic,anti-pathogeny,and anti-bacterial functions.This review was aimed to summarize the use of Gentianaceae herbs for disease treatments and pharmacokinetic characteristics of the active compounds.In so doing,we hope to demonstrate that Gentianaceae herbs and bioactive compounds in them may have abilities to affect inflammation,hepatic metabolism and cell signaling.In addition,we would like to bring this to the attention of the field about the use and study of compounds derived from Gentianaceae herbs.
基金National Key Project of Scientific and Technical Supporting Programs funded by Ministry of Science & Technology of China(No.2006BAD31B05).
文摘From the roots ofPicrorhiza scrophulariiflora, two new secoifidoid glycosides, named picrosecosides Ⅰ and Ⅱ （1, 2） have been isolated. Their structures were elucidated on the basis of chemical and spectropic evidences.
基金National Science and Technology Ministry "Significant new drugs creation" special science and Technology Major (20082X09101-016)
文摘Objective Establishing a fingerprint method to identify the characteristic chemicals in the roots of Gentiana macrophylla and evaluate their quality. Methods RP-HPLC was developed for fingerprint analysis and determination of four ingredients in G. macrophylla roots from different sources. LC-ESI-TOF-MS was employed to identify the chromatographic peaks of the fingerprint. Results Five common peaks were identified by comparing their retention time with reference secoiridoid glucosides. Eight major peaks in chromatographic fingerprint were analyzed by on-line LC-ESI-TOF-MS. Four secoiridoid glucosides were identified based on their MS data. Conclusion The method is specific and could be served for the quality identification and comprehensive evaluation of G. macrophylla.
基金supported by National Natural Science Foundation of China(No.30800835)National Key Project of Scientific and Technical Supporting Programs funded by Ministry of Science & Technology of China(No. 2006BAD31B05)
文摘Two new phenylethanoid glycosides,named scroside H（1）,scroside I（2）,and a new secoiridoid glycoside,named picrogentioside I（3）,have been isolated from the underground parts of Picrorhiza scrophulariiflora.Their structures were elucidated on the basis of spectroscopic evidence.
