摘要
目的:对龙胆科Gentianaceae獐牙菜属植物毛萼獐牙菜Swertia hispidicalyx Burk.的干燥全草进行化学成分研究。方法:采用各种柱色谱进行分离纯化,通过波谱数据分析(MS,1H-,13C-NMR)进行结构鉴定。结果:从乙酸乙酯萃取部分分离鉴定了11个化合物,其中2个口山酮,2个裂环烯醚萜,2个三萜,2个甾体,以及3个其他类化合物,它们分别鉴定为1,3,5,8-四羟基口山酮(1,3,5,8-tetrahydroxyxanthone,1),1,5,8-三羟基-3-甲氧基口山酮(1,5,8-trihydroxy-3-methoxyxanthone,2),龙胆内酯(gentiolactone,3),獐牙菜苦苷(swertiamarin,4),3,4-dihydro-1H,6H,8H-naphtho[1,2-c:4,5-c',d']dipyrano-1,8-dione(5),(+)-丁香脂素[(+)-syringaresinol,6)],松柏醛(trans-coniferyl aldehyde,7),山楂酸(maslinic acid,8),齐墩果酸(oleanolic acid,9),胡萝卜苷(daucosterol,10),β-谷甾醇(β-sitosterol,11)。结论:化合物1～11均为首次从毛萼獐牙菜中分离得到。
Objective： To study the chemical constituents of Swertia hispidicalyx.Method： The EtOAc part of S.hispidicalyx was chromatographied by various column chromatography methods,and the isolates were identified based on spectroscopic analyses（MS,1H-and 13C-NMR）.Result： Eleven compounds were isolated from S.hispidicalyx and characterized as 1,3,5,8-tetrahydroxyxanthone（1）,1,5,8-trihydroxy-3-methoxyxanthone（2）,gentiolactone（3）,swertiamarin（4）,3,4-dihydro-1H,6H,8H-naphtho[1,2-c：4,5-c′,d′]dipyrano-1,8-dione（5）,（＋）-syringaresinol（6）,trans-coniferyl aldehyde（7）,maslinic acid（8）,oleanolic acid（9）,daucosterol（10）,and-sitosterol（11）.Conclusion： Compounds 1-11were obtained from S.hispidicalyx for the first time.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2011年第16期2215-2218,共4页
China Journal of Chinese Materia Medica
基金
国家杰出青年科学基金项目(81025023)
