Novel chiral PN_4-type multidentate aminophosphine ligands have been successfully synthesized by Schiff-base condensation of bis（o-formylphenyl）phenylphosphane and various chiral amino-sulfonamides.Their structures ...Novel chiral PN_4-type multidentate aminophosphine ligands have been successfully synthesized by Schiff-base condensation of bis（o-formylphenyl）phenylphosphane and various chiral amino-sulfonamides.Their structures were fully characterized by IR,EI-MS and NMR.The catalytic systems,prepared in situ from the multidentate ligands and iridium（I） complexes,showed high activity in asymmetric transfer hydrogenation of propiophenone in 2-propanol solution,leading to corresponding optical alcohol with up to 75%ee.展开更多
This report describes a new three‐component strategy for the regioselective synthesis of a series of tri‐substituted pyridazines via a 1,4‐diazabicyclo[2.2.2]octane （DABCO）‐catalyzed condensation of propiophenon...This report describes a new three‐component strategy for the regioselective synthesis of a series of tri‐substituted pyridazines via a 1,4‐diazabicyclo[2.2.2]octane （DABCO）‐catalyzed condensation of propiophenones, arylglyoxalmonohydrates and hydrazine hydrate in water. This method provides a green and convenient one‐pot route toward a diverse set of 3,6‐diaryl‐4‐methylpyridazines bearing various aryl substituents. This procedure is highly regioselective, operationally simple, uses water as a safe, environmentally friendly solvent, and DABCO as a green base‐organocatalyst, and affords good to excellent yields of products.展开更多
基金the National Natural Science Foundation of China(Nos20423002 and 20703034)Natural Science Foundation of Fujian Province of China(No2008J0235) for the financial support of this work
文摘Novel chiral PN_4-type multidentate aminophosphine ligands have been successfully synthesized by Schiff-base condensation of bis（o-formylphenyl）phenylphosphane and various chiral amino-sulfonamides.Their structures were fully characterized by IR,EI-MS and NMR.The catalytic systems,prepared in situ from the multidentate ligands and iridium（I） complexes,showed high activity in asymmetric transfer hydrogenation of propiophenone in 2-propanol solution,leading to corresponding optical alcohol with up to 75%ee.
基金supported by the Research Council of Payame Noor University
文摘This report describes a new three‐component strategy for the regioselective synthesis of a series of tri‐substituted pyridazines via a 1,4‐diazabicyclo[2.2.2]octane （DABCO）‐catalyzed condensation of propiophenones, arylglyoxalmonohydrates and hydrazine hydrate in water. This method provides a green and convenient one‐pot route toward a diverse set of 3,6‐diaryl‐4‐methylpyridazines bearing various aryl substituents. This procedure is highly regioselective, operationally simple, uses water as a safe, environmentally friendly solvent, and DABCO as a green base‐organocatalyst, and affords good to excellent yields of products.
