Introduction: This study describes an intra-operative scoring system to advise the surgeon of the?centricity of the tumour in the excised specimen. Methods: Spatial estimations were prospectively made in 10 consecutiv...Introduction: This study describes an intra-operative scoring system to advise the surgeon of the?centricity of the tumour in the excised specimen. Methods: Spatial estimations were prospectively made in 10 consecutive patients undergoing wide local excision (WLE) using Bioptics intra-operative digital specimen imaging. The centricity score was defined as 100 – (ICD/SD?×?100), where ICD is the inter-centre distance between the specimen’s centre and the tumour’s centre. Results: 10 patients with invasive breast cancer (T1b to T4a), mean age 56 years (range 44 - 71) were studied. The mean tumour and specimen diameter was 24 mm ± 10 (range 12 - 48) and 101 mm ± 22 (range 64 - 140). The mean centricity score was 86 ± 9 (range 65 - 95). Conclusion:?This study successfully?describes an intraoperative radiological spatial scoring system for patients undergoing WLE. Tumours were well centered in specimens with an overall score of 86/100. The centricity score could?be used to guide excision and potentially set benchmarks for conservative breast surgery.展开更多
目的早期宫颈癌标准术式为广泛性子宫切除术,但术后可导致尿瘘,膀胱、排便和性功能障碍等,严重影响患者术后生活质量,究其原因是广泛性子宫切除术切除过多宫旁组织导致。目前早期宫颈癌是否均需切除宫旁组织尚存争议。本研究分析临床早...目的早期宫颈癌标准术式为广泛性子宫切除术,但术后可导致尿瘘,膀胱、排便和性功能障碍等,严重影响患者术后生活质量,究其原因是广泛性子宫切除术切除过多宫旁组织导致。目前早期宫颈癌是否均需切除宫旁组织尚存争议。本研究分析临床早期(ⅠA2~ⅠB1期)宫颈癌宫旁转移率及其相关因素。方法收集2007-01-01-2017-12-31广东医科大学附属龙华中心医院妇科因早期宫颈癌(ⅠA2~ⅠB1期)行广泛性子宫切除术患者的临床病例资料,将宫旁转移与临床病理参数行相关性分析。结果共220例早期宫颈癌(ⅠA2~ⅠB1期)患者纳入研究。其中144例(65.5%)为鳞癌;174例(79.1%)肿瘤直径≤2cm;13例(5.9%)宫旁转移阳性;70例(31.8%)间质浸润深度>10mm;110例(50.0%)宫颈浸润深度>1/2肌层;108例(49.1%)淋巴脉管阳性,18例(8.2%)淋巴结转移阳性,8例(3.6%)切缘阳性。单因素分析结果显示,宫旁转移与间质浸润深度(depth of the stromal invasion,DSI)>10mm(r=0.28,P<0.001)、肿瘤浸润>1/2肌层(r=-0.25,P<0.001)、淋巴脉管浸润(lymphovascular space invasion,LVSI)阳性(r=0.26,P<0.001)、切缘阳性(r=-0.16,P=0.02)和盆腔淋巴结转移阳性(r=0.28,P<0.001)密切相关。多因素分析显示,盆腔淋巴结转移阳性(OR=55.76,95%CI为5.45~570.98)和切缘阳性(P=0.02)是宫旁转移的独立危险因素。结论ⅠA2~ⅠB1期宫颈癌的宫旁转移率低,淋巴结转移阳性和切缘阳性是宫旁转移的独立危险因素。展开更多
文摘Introduction: This study describes an intra-operative scoring system to advise the surgeon of the?centricity of the tumour in the excised specimen. Methods: Spatial estimations were prospectively made in 10 consecutive patients undergoing wide local excision (WLE) using Bioptics intra-operative digital specimen imaging. The centricity score was defined as 100 – (ICD/SD?×?100), where ICD is the inter-centre distance between the specimen’s centre and the tumour’s centre. Results: 10 patients with invasive breast cancer (T1b to T4a), mean age 56 years (range 44 - 71) were studied. The mean tumour and specimen diameter was 24 mm ± 10 (range 12 - 48) and 101 mm ± 22 (range 64 - 140). The mean centricity score was 86 ± 9 (range 65 - 95). Conclusion:?This study successfully?describes an intraoperative radiological spatial scoring system for patients undergoing WLE. Tumours were well centered in specimens with an overall score of 86/100. The centricity score could?be used to guide excision and potentially set benchmarks for conservative breast surgery.
文摘目的早期宫颈癌标准术式为广泛性子宫切除术,但术后可导致尿瘘,膀胱、排便和性功能障碍等,严重影响患者术后生活质量,究其原因是广泛性子宫切除术切除过多宫旁组织导致。目前早期宫颈癌是否均需切除宫旁组织尚存争议。本研究分析临床早期(ⅠA2~ⅠB1期)宫颈癌宫旁转移率及其相关因素。方法收集2007-01-01-2017-12-31广东医科大学附属龙华中心医院妇科因早期宫颈癌(ⅠA2~ⅠB1期)行广泛性子宫切除术患者的临床病例资料,将宫旁转移与临床病理参数行相关性分析。结果共220例早期宫颈癌(ⅠA2~ⅠB1期)患者纳入研究。其中144例(65.5%)为鳞癌;174例(79.1%)肿瘤直径≤2cm;13例(5.9%)宫旁转移阳性;70例(31.8%)间质浸润深度>10mm;110例(50.0%)宫颈浸润深度>1/2肌层;108例(49.1%)淋巴脉管阳性,18例(8.2%)淋巴结转移阳性,8例(3.6%)切缘阳性。单因素分析结果显示,宫旁转移与间质浸润深度(depth of the stromal invasion,DSI)>10mm(r=0.28,P<0.001)、肿瘤浸润>1/2肌层(r=-0.25,P<0.001)、淋巴脉管浸润(lymphovascular space invasion,LVSI)阳性(r=0.26,P<0.001)、切缘阳性(r=-0.16,P=0.02)和盆腔淋巴结转移阳性(r=0.28,P<0.001)密切相关。多因素分析显示,盆腔淋巴结转移阳性(OR=55.76,95%CI为5.45~570.98)和切缘阳性(P=0.02)是宫旁转移的独立危险因素。结论ⅠA2~ⅠB1期宫颈癌的宫旁转移率低,淋巴结转移阳性和切缘阳性是宫旁转移的独立危险因素。
