摘要
目的分析高级别宫颈鳞状上皮内病变患者宫颈锥切术后切缘阳性的影响因素.方法选取2014年3月-2019年12月珠海市人民医院收治的86例宫颈高级别鳞状上皮内病变患者,均接受宫颈锥切术,按术后切缘阳性情况,分为阳性组(16例)和阴性组(70例).比较两组术后残留率、复发率及人乳头瘤病毒(HPV)阳性率.采用多因素Logistic回归分析高级别宫颈鳞状上皮内病变患者宫颈锥切术后切缘阳性的影响因素.结果多因素Logistic回归分析结果显示:孕次、HPV阳性及术后病理检查切缘病变点数均是高级别宫颈鳞状上皮内病变患者宫颈锥切术后切缘阳性的影响因素(均OR>1,P<0.05).阳性组术后残留率和复发率分别为25.00%和12.50%,均显著高于阴性组的2.86%和1.43%(χ^(2)=9.839,P=0.002;χ^(2)=4.742,P=0.029).结论孕次、HPV阳性及术后病理检查切缘病变点数均是高级别宫颈鳞状上皮内病变患者宫颈锥切术后切缘阳性的影响因素,病理切缘阳性患者的复发率较高.
Objective To analyze the influencing factors of positive margin after cervical conization in patients with high-grade cervical squamous intraepithelial lesion.Methods From March 2014 to December 2019,86 patients with high-grade cervical squamous intraepithelial lesion treated in Zhuhai People’s Hospital were selected,then cervical conization was performed,according to positive margin or not after cervical conization,these patients were divided into positive group(16 cases)and negative group(70 cases).The residual rates,recurrence rates,and human papillomavirus(HPV)positive rates in the two groups were compared.Multivariate Logistic regression analysis was used to analyze the influencing factors of positive margin after cervical conization in patients with high-grade cervical squamous intraepithelial lesion.Results Multivariate Logistic regression analysis showed that gravidity,positive HPV,and the lesion number of margin after postoperative pathological examination were influencing factors of positive margin after cervical conization in patients with high-grade cervical squamous intraepithelial lesion(OR>1,P<0.05).The residual rate and recurrence rate in positive group were 25.00%and 12.50%,respectively,which were statistically significantly higher than those in negative group(2.86%and 1.43%,respectively)(χ^(2)=9.839,P=0.002;χ^(2)=4.742,P=0.029).Conclusion Gravidity,positive HPV,and the lesion number of margin after postoperative pathological examination are influencing factors of positive margin after cervical conization in patients with high-grade cervical squamous intraepithelial lesion,the recurrence rate in patients with positive margin after cervical conization is high.
作者
闫彩平
黎华文
邓鹏飞
李宗涛
朱玲娜
陈宛
YAN Cai-Ping;LI Hua-Wen;DENG Peng-Fei(Department of Gynecology,Zhuhai People’s Hospital,Zhuhai,Guangdong 519000,China)
出处
《中国妇幼保健》
CAS
2021年第14期3305-3308,共4页
Maternal and Child Health Care of China
基金
广东省科学技术厅自筹经费类科技计划项目(2015Z0280)。
关键词
宫颈鳞状上皮内病变
宫颈锥切术
切缘阳性
影响因素
Cervical squamous intraepithelial lesion
Cervical conization
Positive margin
Influencing factor
