鉴于射频识别(RFID)标签芯片苛刻的资源要求,为解决差分功耗分析(Differential Power Analysis,DPA)对密码算法实现方面的威胁难题,将新型DPA防护技术threshold与Piccolo密码算法相结合,提出了一种适用于RFID标签芯片应用的安全化密码...鉴于射频识别(RFID)标签芯片苛刻的资源要求,为解决差分功耗分析(Differential Power Analysis,DPA)对密码算法实现方面的威胁难题,将新型DPA防护技术threshold与Piccolo密码算法相结合,提出了一种适用于RFID标签芯片应用的安全化密码算法实现方案.分别基于布尔式重组和改进型穷举搜索的方式实现了面积最优的S盒及其逆的threshold(3,3)分享,提出了基于锁存器方式解决S盒及其逆实现中潜在的毛刺威胁问题,在Chartered 0.18μm工艺和100 kHz RFID运行频率下,将该方案的资源消耗控制在2155个等效门,平均电流约为2.60μA,基于FPGA的DPA攻击安全性分析结果表明该方案适合于低成本RFID标签芯片对密码算法轻型及实现安全的要求.展开更多
Major aortopulmonary collateral arteries (MAPCAs) are congenital vessels that arise from the aorta or its first-order branches and are distally connected to the pulmonary arterial vasculature, thereby providing pulmon...Major aortopulmonary collateral arteries (MAPCAs) are congenital vessels that arise from the aorta or its first-order branches and are distally connected to the pulmonary arterial vasculature, thereby providing pulmonary blood flow. MAPCAs are often associated with cyanotic congenital heart disease with decreased pulmonary blood flow. Isolated MAPCAs are rare in patients without congenital heart disease with structurally normal hearts. Sometimes, isolated congenital MAPCAs can occur without any lung disease. Isolated MAPCAs represent the occurrence of collaterals in the absence of underlying heart disease, which commonly presents as heart failure, recurrent respiratory tract infection, and pulmonary artery hypertension. We report a rare case of congestive heart failure in a 6-year-old patient with dual arterial supply to an otherwise normal right lung, with a normal bronchial tree, and a structurally normal heart. The patient was successfully managed by the closure of collaterals by Amplatzer vascular plugs II (AVPII) and Amplatzer Piccolo Occluders.展开更多
Ethylene thiourea(ETU)converted from ethylene bisdithiocarbamate(EBDC)fungicides has aroused great concern because of its prevalence and harmful effects.Although ETU-induced neurotoxicity has been reported,the potenti...Ethylene thiourea(ETU)converted from ethylene bisdithiocarbamate(EBDC)fungicides has aroused great concern because of its prevalence and harmful effects.Although ETU-induced neurotoxicity has been reported,the potential mechanisms remain unclear.This study provided insights into its neurotoxic effects at environmentally relevant concentrations in zebrafish.Our findings showed that embryonic exposure to ETU decreased the hatch rate and delayed somite development.Furthermore,ETU treatment significantly reduced the dark velocity in the locomotion assay.The upregulated tendency of the mitogen-activated protein kinases(MAPK)pathway(mknk1,atf4,mapkapk3)screened by transcriptome analysis implied motor neuron degeneration,which was validated by subsequent morphological observation,as axon length and branches were truncated in the 62.5μg/L ETU group.However,although the rescue experiment with a p38 MAPK inhibitor(SB203580)successfully ameliorated axon degeneration,it failed to reverse the locomotion behaviors.Further exploration of transcriptome data revealed the varied expression of presynaptic scaffold protein-related genes(pcloa,pclob,bsna),whose downregulation might impair the neuromuscular junction(NMJ).Therefore,we reasonably suspected that ETU-induced neurobehavioral deficits might result from the combined effects of the MAPK pathway and presynaptic proteins.Considering this,we highlighted the necessity to take precautions and early interventions for susceptible ETU-exposed populations.展开更多
为了评估Piccolo密码算法的功耗分析安全性,该文提出一种针对Piccolo末轮的攻击模型,基于SASEBO(Side-channel Attack Standard Evaluation BOard)实测功耗数据对该算法进行了相关性功耗分析攻击。针对Piccolo末轮运算中包含白化密钥的...为了评估Piccolo密码算法的功耗分析安全性,该文提出一种针对Piccolo末轮的攻击模型,基于SASEBO(Side-channel Attack Standard Evaluation BOard)实测功耗数据对该算法进行了相关性功耗分析攻击。针对Piccolo末轮运算中包含白化密钥的特点,将末轮攻击密钥(包括轮密钥RK24L,RK24R,WK2,WK3)分成4段子密钥,逐个完成各个子密钥的攻击,使80位种子密钥的搜索空间从280降低到(2×220+2×212+216),使种子密钥的恢复成为可能。攻击结果表明,在实测功耗数据情况下,3000条功耗曲线即可恢复80位种子密钥,证实了该攻击模型的有效性和Piccolo硬件面向功耗分析的脆弱性,研究并采取切实有效的防护措施势在必行。展开更多
文摘Major aortopulmonary collateral arteries (MAPCAs) are congenital vessels that arise from the aorta or its first-order branches and are distally connected to the pulmonary arterial vasculature, thereby providing pulmonary blood flow. MAPCAs are often associated with cyanotic congenital heart disease with decreased pulmonary blood flow. Isolated MAPCAs are rare in patients without congenital heart disease with structurally normal hearts. Sometimes, isolated congenital MAPCAs can occur without any lung disease. Isolated MAPCAs represent the occurrence of collaterals in the absence of underlying heart disease, which commonly presents as heart failure, recurrent respiratory tract infection, and pulmonary artery hypertension. We report a rare case of congestive heart failure in a 6-year-old patient with dual arterial supply to an otherwise normal right lung, with a normal bronchial tree, and a structurally normal heart. The patient was successfully managed by the closure of collaterals by Amplatzer vascular plugs II (AVPII) and Amplatzer Piccolo Occluders.
基金supported by the National Key R&D Program of China (Nos.2018YFC1004300 and 2018YFC1004304)。
文摘Ethylene thiourea(ETU)converted from ethylene bisdithiocarbamate(EBDC)fungicides has aroused great concern because of its prevalence and harmful effects.Although ETU-induced neurotoxicity has been reported,the potential mechanisms remain unclear.This study provided insights into its neurotoxic effects at environmentally relevant concentrations in zebrafish.Our findings showed that embryonic exposure to ETU decreased the hatch rate and delayed somite development.Furthermore,ETU treatment significantly reduced the dark velocity in the locomotion assay.The upregulated tendency of the mitogen-activated protein kinases(MAPK)pathway(mknk1,atf4,mapkapk3)screened by transcriptome analysis implied motor neuron degeneration,which was validated by subsequent morphological observation,as axon length and branches were truncated in the 62.5μg/L ETU group.However,although the rescue experiment with a p38 MAPK inhibitor(SB203580)successfully ameliorated axon degeneration,it failed to reverse the locomotion behaviors.Further exploration of transcriptome data revealed the varied expression of presynaptic scaffold protein-related genes(pcloa,pclob,bsna),whose downregulation might impair the neuromuscular junction(NMJ).Therefore,we reasonably suspected that ETU-induced neurobehavioral deficits might result from the combined effects of the MAPK pathway and presynaptic proteins.Considering this,we highlighted the necessity to take precautions and early interventions for susceptible ETU-exposed populations.
文摘为了评估Piccolo密码算法的功耗分析安全性,该文提出一种针对Piccolo末轮的攻击模型,基于SASEBO(Side-channel Attack Standard Evaluation BOard)实测功耗数据对该算法进行了相关性功耗分析攻击。针对Piccolo末轮运算中包含白化密钥的特点,将末轮攻击密钥(包括轮密钥RK24L,RK24R,WK2,WK3)分成4段子密钥,逐个完成各个子密钥的攻击,使80位种子密钥的搜索空间从280降低到(2×220+2×212+216),使种子密钥的恢复成为可能。攻击结果表明,在实测功耗数据情况下,3000条功耗曲线即可恢复80位种子密钥,证实了该攻击模型的有效性和Piccolo硬件面向功耗分析的脆弱性,研究并采取切实有效的防护措施势在必行。
