目的探讨体质指数(BMI)和体脂百分比(PBF)与类风湿关节炎(RA)继发骨质疏松(OP)间的相关性。方法采用生物电阻抗体成分测定法测量359例RA患者和158例年龄、性别相匹配的正常对照组体重(kg)、身高(m)和PBF,根据体重/(身高)2计算出BMI,并将...目的探讨体质指数(BMI)和体脂百分比(PBF)与类风湿关节炎(RA)继发骨质疏松(OP)间的相关性。方法采用生物电阻抗体成分测定法测量359例RA患者和158例年龄、性别相匹配的正常对照组体重(kg)、身高(m)和PBF,根据体重/(身高)2计算出BMI,并将BMI分为4组:消瘦BMI<18.5,正常24>BMI≥18.5,超重28>BMI≥24,肥胖BMI≥28;PBF分为2组:肥胖为PBF男>25%或女>30%,否则为正常。采用双能X线骨密度吸收仪测定髋部(包括股骨颈Neck、Ward三角区、大转子GT、总髋部Hip)及腰椎1-4(L1-4)骨密度(BMD)。结果 RA患者BMI低于正常对照组(22.40±3.76 vs 23.66±3.24,t=3.813,P<0.0001),其中消瘦患者百分比明显高于对照组(14.4%vs 5.8%,x^2=10.536,P=0.015);而PBF则高于对照组(32.45±10.38 vs 30.53±6.98,t=2.442,P=0.015)。RA患者OP发生率为37.9%(128/338),明显高于对照组的13.9%(22/158)(x^2=29.265,P<0.0001)。RA患者不同BMI分组间各部位BMD均有显著不同,且都表现为消瘦组水平更低,超重或肥胖组水平更高(P<0.0001～0.05);除Ward区的PBF正常组BMD高于肥胖组(t=2.224,P=0.027)外,其余各部位BMD均无明显差别(P>0.05)。Hip区和L1-4区均表现为消瘦组OP发生率(27.8%、20.7%)明显高于肥胖组(3.7%、1.1%)(x^2=22.041,P=0.001;x^2=13.401,P=0.037)。不同PBF分组间骨量构成比的比较无差别(P>0.05)。各部位BMD均与BMI成正直线相关(P<0.0001～0.01);而Ward、GT、Hip区BMD与PBF成负直线相关(P=0.015～0.04)。多元Logistic回归分析结果显示:年龄(OR=1.114,95%CI:1.082～1.148,P<0.0001)、性别(OR=5.802,95%CI:2.608～12.906,P<0.0001)和病程(OR=1.050,95%CI:1.017～1.084,P=0.003)均为RA患者发生OP的危险因素,而BMI(OR=0.879,95%CI:0.815～0.946,P=0.001)为发生OP的保护因素。结论 BMI和PBF在RA中变化不同,且呈现出与BMD相反的相关性,BMI是RA患者发生OP的保护因素。展开更多
Air-core photonic bandgap fiber(PBF)is the perfect choice of the next-generation fiber optical gyroscope(FOG),with excellent temperature,electromagnetism and radiation adaptability.Numerical aperture is an important o...Air-core photonic bandgap fiber(PBF)is the perfect choice of the next-generation fiber optical gyroscope(FOG),with excellent temperature,electromagnetism and radiation adaptability.Numerical aperture is an important optical parameter of PBF for application in FOG.The PBF’s maximum theoretical numerical aperture(NAmax)is calculated and compared with the far-field numerical aperture(NAeff)through experiments.The result indicates that the relationship between NAmax and NAeff has much stronger dependence on wavelength than that of the conventional fiber,and they get close at wavelengths near the middle of the photonic bandgap with the error less than 5%.Furthermore,photonic bandgap fiber optical gyroscope(PBFOG)with no fusion splicing points is proposed,and the optimization method and results of the PBF’s structure parameters for application in PBFOG are given from the aspect of numerical aperture.展开更多
[Objective] This study aimed to investigate the polymorphism of PBF en- coding genes from common wheat Chinese Spring （Triticum aestivum L.）. [Method] Using common wheat Chinese Spring as the experimental material, ...[Objective] This study aimed to investigate the polymorphism of PBF en- coding genes from common wheat Chinese Spring （Triticum aestivum L.）. [Method] Using common wheat Chinese Spring as the experimental material, gene-specific primers were designed and applied to amplify the genomic DNA of Chinese Spring. PCR products were isolated, purified and ligated into the cloning vector. Positive clones were randomly selected for sequencing. A series of softwares including DNAMAN, Signalp, PSIPRED, Nuc_PLoc and MEGA were employed for sequence assembly and alignment, signal peptide prediction, primary and secondary structure prediction, as well as analyses of subcellular location and phylogenetic relationships between the PBF family members in Poaceae. [Result] Twenty-five target sequences were obtained from the genome of hexaploid common wheat Chinese Spring, which were classified into three clusters based on the sequence similarity. SNPs exist at two loci of the subunit, resulting in the change of encoded amino acid residues and affecting the secondary structure of final product encoded. [Conclusion] PBF encoding sequences are extremely conservative in Chinese Spring with certain variations. This study provides theoretical reference to evaluate the expression efficiency of wheat storage proteins.展开更多
目的分析15~岁组廊坊市居民不同体质指数(Body Mass Index,BMI)、腰围(Waist Circumference,WC)、内脏脂肪指数(Visceral Fat Index,VFI)、身体脂肪率(Percentage Body Fat,PBF)等肥胖指标与高血压分布特征的关系,为高血压、肥胖防治工...目的分析15~岁组廊坊市居民不同体质指数(Body Mass Index,BMI)、腰围(Waist Circumference,WC)、内脏脂肪指数(Visceral Fat Index,VFI)、身体脂肪率(Percentage Body Fat,PBF)等肥胖指标与高血压分布特征的关系,为高血压、肥胖防治工作提供科学依据。方法对不同居民BMI、WC、VFI、PBF的分布特征进行分析,并对肥胖与高血压流行关系进行分析。结果在3 775名廊坊市居民中,高血压病人1 103人,患病率29.2%;随BMI、VFI、PBF增长,廊坊市居民高血压患病率呈逐渐升高趋势,差异有统计学意义(χ~2=229.231、160.900、11.834,P<0.01);中心性肥胖居民高血压患病率高于正常居民,差异有统计学意义(χ~2=205.741,P<0.01)。结论廊坊市居民高血压患病与肥胖密切相关,应加强健康教育,使居民养成平衡膳食、适度睡眠、积极锻炼的健康生活方式,以有效控制体重,进一步降低居民高血压患病率。展开更多
文摘目的探讨体质指数(BMI)和体脂百分比(PBF)与类风湿关节炎(RA)继发骨质疏松(OP)间的相关性。方法采用生物电阻抗体成分测定法测量359例RA患者和158例年龄、性别相匹配的正常对照组体重(kg)、身高(m)和PBF,根据体重/(身高)2计算出BMI,并将BMI分为4组:消瘦BMI<18.5,正常24>BMI≥18.5,超重28>BMI≥24,肥胖BMI≥28;PBF分为2组:肥胖为PBF男>25%或女>30%,否则为正常。采用双能X线骨密度吸收仪测定髋部(包括股骨颈Neck、Ward三角区、大转子GT、总髋部Hip)及腰椎1-4(L1-4)骨密度(BMD)。结果 RA患者BMI低于正常对照组(22.40±3.76 vs 23.66±3.24,t=3.813,P<0.0001),其中消瘦患者百分比明显高于对照组(14.4%vs 5.8%,x^2=10.536,P=0.015);而PBF则高于对照组(32.45±10.38 vs 30.53±6.98,t=2.442,P=0.015)。RA患者OP发生率为37.9%(128/338),明显高于对照组的13.9%(22/158)(x^2=29.265,P<0.0001)。RA患者不同BMI分组间各部位BMD均有显著不同,且都表现为消瘦组水平更低,超重或肥胖组水平更高(P<0.0001～0.05);除Ward区的PBF正常组BMD高于肥胖组(t=2.224,P=0.027)外,其余各部位BMD均无明显差别(P>0.05)。Hip区和L1-4区均表现为消瘦组OP发生率(27.8%、20.7%)明显高于肥胖组(3.7%、1.1%)(x^2=22.041,P=0.001;x^2=13.401,P=0.037)。不同PBF分组间骨量构成比的比较无差别(P>0.05)。各部位BMD均与BMI成正直线相关(P<0.0001～0.01);而Ward、GT、Hip区BMD与PBF成负直线相关(P=0.015～0.04)。多元Logistic回归分析结果显示:年龄(OR=1.114,95%CI:1.082～1.148,P<0.0001)、性别(OR=5.802,95%CI:2.608～12.906,P<0.0001)和病程(OR=1.050,95%CI:1.017～1.084,P=0.003)均为RA患者发生OP的危险因素,而BMI(OR=0.879,95%CI:0.815～0.946,P=0.001)为发生OP的保护因素。结论 BMI和PBF在RA中变化不同,且呈现出与BMD相反的相关性,BMI是RA患者发生OP的保护因素。
基金supported by the National Natural Science Foundation of China(Grant No.61205077)
文摘Air-core photonic bandgap fiber(PBF)is the perfect choice of the next-generation fiber optical gyroscope(FOG),with excellent temperature,electromagnetism and radiation adaptability.Numerical aperture is an important optical parameter of PBF for application in FOG.The PBF’s maximum theoretical numerical aperture(NAmax)is calculated and compared with the far-field numerical aperture(NAeff)through experiments.The result indicates that the relationship between NAmax and NAeff has much stronger dependence on wavelength than that of the conventional fiber,and they get close at wavelengths near the middle of the photonic bandgap with the error less than 5%.Furthermore,photonic bandgap fiber optical gyroscope(PBFOG)with no fusion splicing points is proposed,and the optimization method and results of the PBF’s structure parameters for application in PBFOG are given from the aspect of numerical aperture.
基金Supported by National Natural Science Foundation of China(30900896)Special Fund for the Construction of Modern Agricultural Technology System(NYCYTX-001)Cyrus Tang Breeding Fund(A212020912)~~
文摘[Objective] This study aimed to investigate the polymorphism of PBF en- coding genes from common wheat Chinese Spring （Triticum aestivum L.）. [Method] Using common wheat Chinese Spring as the experimental material, gene-specific primers were designed and applied to amplify the genomic DNA of Chinese Spring. PCR products were isolated, purified and ligated into the cloning vector. Positive clones were randomly selected for sequencing. A series of softwares including DNAMAN, Signalp, PSIPRED, Nuc_PLoc and MEGA were employed for sequence assembly and alignment, signal peptide prediction, primary and secondary structure prediction, as well as analyses of subcellular location and phylogenetic relationships between the PBF family members in Poaceae. [Result] Twenty-five target sequences were obtained from the genome of hexaploid common wheat Chinese Spring, which were classified into three clusters based on the sequence similarity. SNPs exist at two loci of the subunit, resulting in the change of encoded amino acid residues and affecting the secondary structure of final product encoded. [Conclusion] PBF encoding sequences are extremely conservative in Chinese Spring with certain variations. This study provides theoretical reference to evaluate the expression efficiency of wheat storage proteins.
文摘目的分析15~岁组廊坊市居民不同体质指数(Body Mass Index,BMI)、腰围(Waist Circumference,WC)、内脏脂肪指数(Visceral Fat Index,VFI)、身体脂肪率(Percentage Body Fat,PBF)等肥胖指标与高血压分布特征的关系,为高血压、肥胖防治工作提供科学依据。方法对不同居民BMI、WC、VFI、PBF的分布特征进行分析,并对肥胖与高血压流行关系进行分析。结果在3 775名廊坊市居民中,高血压病人1 103人,患病率29.2%;随BMI、VFI、PBF增长,廊坊市居民高血压患病率呈逐渐升高趋势,差异有统计学意义(χ~2=229.231、160.900、11.834,P<0.01);中心性肥胖居民高血压患病率高于正常居民,差异有统计学意义(χ~2=205.741,P<0.01)。结论廊坊市居民高血压患病与肥胖密切相关,应加强健康教育,使居民养成平衡膳食、适度睡眠、积极锻炼的健康生活方式,以有效控制体重,进一步降低居民高血压患病率。
