Under mild conditions, conversion of a variety of ketoximes and aldoximes to their corresponding amides and nitriles proceeded in the presence of PEG-SO3H with high yields.
A facile and efficient approach to the synthesis of secondary thioamides from ketoximes via Beckmann rearrangement has been established, using phosphorus pentasulfide as a dehydrating and thiating agent. It is also ef...A facile and efficient approach to the synthesis of secondary thioamides from ketoximes via Beckmann rearrangement has been established, using phosphorus pentasulfide as a dehydrating and thiating agent. It is also efficient for the preparation of primary thiobenzamide from benzaldoxime. This approach features simple-operation, easy-control and good to excellent yields.展开更多
The Beckmann rearrangement of cyclohexanone oxime was achieved by the combined use of cobalt salt and Lewis acids co-catalysts (each 10 mol%). Various combinations of cobalt salts and Lewis acids gave lactams in a sat...The Beckmann rearrangement of cyclohexanone oxime was achieved by the combined use of cobalt salt and Lewis acids co-catalysts (each 10 mol%). Various combinations of cobalt salts and Lewis acids gave lactams in a satisfactory yield under mild conditions. This method makes it possible to reduce undesirable byproducts.展开更多
A dehydroxylative ring-opening Giese reaction of cyclobutanone oximes enabled by photoredox/Ti dual catalysis has been reported in this work.This protocol avoids the prefunctionalization of oximes and the use of stoic...A dehydroxylative ring-opening Giese reaction of cyclobutanone oximes enabled by photoredox/Ti dual catalysis has been reported in this work.This protocol avoids the prefunctionalization of oximes and the use of stoichiometric triarylphosphine reagents.It also features mild conditions,broad substrate scope and good functional group tolerance.The gram-scale reaction,product derivatization,late-stage functionalization of complex pharmaceutical and natural product derivatives,and oligopeptide modification exhibit the potential application of this methodology in synthetic chemistry.展开更多
Dioxane-NO2 was employed to oxidize oximes to corresponding aldehydes and ketones in high yield in nonaqueous condition at room temperature. Thr reaction proved to be mild and selective.
A wide variety of aldoximes and ketoximes were regenerated to corresponding carbonyl compounds with Al（NO3）3·9H2O in presence of catalytic amounts of NaBr in CH2Cl2 at room temperature.
New pyrimidine nucleoside derivatives with nitric oxide（NO） donor were systematically synthesized.The antivirus activities of these nucleoside analogues against vesicular stomatitis virus（VSV） in Wish cell were ev...New pyrimidine nucleoside derivatives with nitric oxide（NO） donor were systematically synthesized.The antivirus activities of these nucleoside analogues against vesicular stomatitis virus（VSV） in Wish cell were evaluated.It was demonstrated that most of compounds had stronger antiviral acitivity than acyclovir,while their toxicities were similar or lower to acyclovir.展开更多
Silica sulfuric acid in which sulfuric acid is immobilized on the surface of silica gel via covalent bond has been proved to be green catalyst for liquid-phase Beckmann rearrangement of oximes in dried dioxane at room...Silica sulfuric acid in which sulfuric acid is immobilized on the surface of silica gel via covalent bond has been proved to be green catalyst for liquid-phase Beckmann rearrangement of oximes in dried dioxane at room temperature. Excellent conversion and selectivity were acquired in the Beckmann rearrangement of cyclohexanone oxime. The catalyst system was recycled and reused.展开更多
A convenient copper-catalyzed approach has been developed for the synthesis of substituted spiro-fused pyrazolin-5-ones from readily available cyclopropyl O-acyl ketoximes via an intramolecular N-N bond formation reac...A convenient copper-catalyzed approach has been developed for the synthesis of substituted spiro-fused pyrazolin-5-ones from readily available cyclopropyl O-acyl ketoximes via an intramolecular N-N bond formation reaction. These catalytic reactions proceed in excellent yields with a broad scope.展开更多
A variety of carbonyl compounds can be converted into oximes efficiently and conveniently in a novel ionic liquid/water bi-phasic system in the presence of sodium bicarbonate at ambient temperature. The ionic liquid 1...A variety of carbonyl compounds can be converted into oximes efficiently and conveniently in a novel ionic liquid/water bi-phasic system in the presence of sodium bicarbonate at ambient temperature. The ionic liquid 1-butyl-3-methyl imidazolium hexafluorophosphate [bmim]PF6 is immiscible with water or diethyl ether and can be easily recycled for reuse without noticeable droping in activity after separation of the products. The protocol is rapid, the yields are excellent, the method is simple and the ionic liquid can be reused.展开更多
基金support from the Natural Science Foundation of Gansu Province(No.3ZS061-A25-019)the Scientific Research fund of Gansu Provincial Education Department(No.0601-25)
文摘Under mild conditions, conversion of a variety of ketoximes and aldoximes to their corresponding amides and nitriles proceeded in the presence of PEG-SO3H with high yields.
文摘A facile and efficient approach to the synthesis of secondary thioamides from ketoximes via Beckmann rearrangement has been established, using phosphorus pentasulfide as a dehydrating and thiating agent. It is also efficient for the preparation of primary thiobenzamide from benzaldoxime. This approach features simple-operation, easy-control and good to excellent yields.
文摘The Beckmann rearrangement of cyclohexanone oxime was achieved by the combined use of cobalt salt and Lewis acids co-catalysts (each 10 mol%). Various combinations of cobalt salts and Lewis acids gave lactams in a satisfactory yield under mild conditions. This method makes it possible to reduce undesirable byproducts.
基金grateful for the financial support from the National Natural Science Foundation of China(Nos.22101135 and 21502096)the Natural Science Foundation of Jiangsu Province(No.BK20150652)+1 种基金the Fundamental Research Funds for the Central Universities(Nos.KYQN2022058,KJQN201629 and XUEKEN2022032)“333 High-Level Talent Project”of Jiangsu Province.
文摘A dehydroxylative ring-opening Giese reaction of cyclobutanone oximes enabled by photoredox/Ti dual catalysis has been reported in this work.This protocol avoids the prefunctionalization of oximes and the use of stoichiometric triarylphosphine reagents.It also features mild conditions,broad substrate scope and good functional group tolerance.The gram-scale reaction,product derivatization,late-stage functionalization of complex pharmaceutical and natural product derivatives,and oligopeptide modification exhibit the potential application of this methodology in synthetic chemistry.
基金the National Natural Science Foundation of China and Henan Province Education Committee.
文摘Dioxane-NO2 was employed to oxidize oximes to corresponding aldehydes and ketones in high yield in nonaqueous condition at room temperature. Thr reaction proved to be mild and selective.
基金support for this work by the research facilities of Ilam University
文摘A wide variety of aldoximes and ketoximes were regenerated to corresponding carbonyl compounds with Al（NO3）3·9H2O in presence of catalytic amounts of NaBr in CH2Cl2 at room temperature.
基金the National Natural Science Foundation of China(No.30572240)
文摘New pyrimidine nucleoside derivatives with nitric oxide（NO） donor were systematically synthesized.The antivirus activities of these nucleoside analogues against vesicular stomatitis virus（VSV） in Wish cell were evaluated.It was demonstrated that most of compounds had stronger antiviral acitivity than acyclovir,while their toxicities were similar or lower to acyclovir.
文摘Silica sulfuric acid in which sulfuric acid is immobilized on the surface of silica gel via covalent bond has been proved to be green catalyst for liquid-phase Beckmann rearrangement of oximes in dried dioxane at room temperature. Excellent conversion and selectivity were acquired in the Beckmann rearrangement of cyclohexanone oxime. The catalyst system was recycled and reused.
文摘A convenient copper-catalyzed approach has been developed for the synthesis of substituted spiro-fused pyrazolin-5-ones from readily available cyclopropyl O-acyl ketoximes via an intramolecular N-N bond formation reaction. These catalytic reactions proceed in excellent yields with a broad scope.
基金The project was supported by the National Natural Science Foundation of China(No 20272018)the Guangdong Natural Science Foundation(No 021166,04010458)the Scientific Research Foundation for the Retumed Overseas Chinese Scholars,State Education Ministry of China.
文摘A variety of carbonyl compounds can be converted into oximes efficiently and conveniently in a novel ionic liquid/water bi-phasic system in the presence of sodium bicarbonate at ambient temperature. The ionic liquid 1-butyl-3-methyl imidazolium hexafluorophosphate [bmim]PF6 is immiscible with water or diethyl ether and can be easily recycled for reuse without noticeable droping in activity after separation of the products. The protocol is rapid, the yields are excellent, the method is simple and the ionic liquid can be reused.
