Central granular cell odontogenic tumors(CGCOTs)are rare,benign,slowly growing odontogenic neoplasms.Due to their uncertain histogenesis,CGCOTs are still not included as a distinct entity in the WHO classification(201...Central granular cell odontogenic tumors(CGCOTs)are rare,benign,slowly growing odontogenic neoplasms.Due to their uncertain histogenesis,CGCOTs are still not included as a distinct entity in the WHO classification(2017)of odontogenic tumors.We report a case of CGCOT involving the right side of maxillary anterior region of a 39-year-old white female.Immunohistochemical staining showed that granular cells positively expressed CD68 and vimentin,and negatively expressed S-100 protein.Meanwhile,we searched Pub Med,Google Scholar,and Scopus databases to summary the clinico-pathological features of 51 reported cases of CGCOT.The results showed that the granular cells of 28.6%cases were immunopositive for vimentin and CD68,and odontogenic epithelial cells were positive immunoreactivity for cytokeratin.These findings reinforced the mesenchymal origin of granular cells and the odontogenic nature of epithelium islands.展开更多
BACKGROUND Sclerosing odontogenic carcinoma is a rare primary intraosseous neoplasm that was featured recently as a single entity in the World Health Organization classification of Head and Neck Tumors 2017,with only ...BACKGROUND Sclerosing odontogenic carcinoma is a rare primary intraosseous neoplasm that was featured recently as a single entity in the World Health Organization classification of Head and Neck Tumors 2017,with only 14 cases published to date.The biological characteristics of sclerosing odontogenic carcinoma remain indistinct because of its rarity;however,it appears to be locally aggressive,with no regional or distant metastasis reported to date.CASE SUMMARY We reported a case of sclerosing odontogenic carcinoma of the maxilla in a 62-year-old woman,who presented with an indolent right palatal swelling,which progressively increased in size over 7 years.Right subtotal maxillectomy with surgical margins of approximately 1.5 cm was performed.The patient remained disease free for 4 years following the ablation surgery.Diagnostic workups,treatment,and therapeutic outcomes were discussed.CONCLUSION More cases are needed to further characterize this entity,understand its biological behavior,and justify the treatment protocols.Resection with wide margins of approximately 1.0 to 1.5 cm is proposed,while neck dissection,post-operative radiotherapy,or chemotherapy are deemed unnecessary.展开更多
Ameloblastoma—a benign epithelial odontogenic tumor-histologically occurs in different patterns, the most common of which are plexiform and follicular. “Hybrid” ameloblastoma is a variant in which areas of follicul...Ameloblastoma—a benign epithelial odontogenic tumor-histologically occurs in different patterns, the most common of which are plexiform and follicular. “Hybrid” ameloblastoma is a variant in which areas of follicular or plexiform pattern (generally called convention alameloblastoma) coexist with areas of pronounced stromal desmoplasia (desmoplastic ameloblastoma). They most often occur in the mandibular ramus. We present a case of “hybrid” lesion—desmoplastic and conventional ameloblastoma—in the anterior mandible, focusing on its’ imaging features.展开更多
Adenomatoid odontogenic tumor is an unusual benign neoplasm which shares clinical and radiographic characteristics with odontogenic cystic lesions denoting a distinct behavior. This paper reports a case of a 12-year-o...Adenomatoid odontogenic tumor is an unusual benign neoplasm which shares clinical and radiographic characteristics with odontogenic cystic lesions denoting a distinct behavior. This paper reports a case of a 12-year-old boy with a bony consistence tumefaction involving the area from teeth 12 to 17. Radiographically, the lesion was characterized by a well-circum- scribed unilocular radiolucent area displacing maxillary canine, first and second premolars. The final diagnosis was adenomatoid odontogenic tumour. The lesion was enucleated concomitantly with the removal of the canine tooth under general anesthesia. The patient was submitted to orthodontic treatment and has been followed-up for four years. Clinical and radiographic features are discussed in this report.展开更多
The desmoplastic ameloblastoma (DA) is a rare variant of the conventional ameloblastoma. It accounts for only 4% to 13% of all ameloblastomas. Desmoplastic ameloblastoma (DA) was included in the World Health Organizat...The desmoplastic ameloblastoma (DA) is a rare variant of the conventional ameloblastoma. It accounts for only 4% to 13% of all ameloblastomas. Desmoplastic ameloblastoma (DA) was included in the World Health Organization Classification of Head and Neck Tumors (WHO-2005) as a variant of ameloblastoma with specific clinical, imaging and histological features. The desmoplastic variant of ameloblastoma usually appears in the anterior and premolar regions as a mixed radiolucent and radiopaque lesion, sometimes resembling a benign fibro-osseous lesion [1]. Ameloblastoma is a locally aggressive tumor that may cause recurrence and in rare cases, malignant transformation with repeated postsurgical recurrences [2] [3]. In this paper we present a case of a 47-year-old female with swelling in the left upper jaw, bopsy of which turned out to be desmoplastic ameloblastoma.展开更多
Odontoma is a hamartomatous lesion of odontogenic origin involving both epithelial and mesenchymal tissues. Although it is not an uncommon lesion yet in certain conditions it can lead to complications if left untreate...Odontoma is a hamartomatous lesion of odontogenic origin involving both epithelial and mesenchymal tissues. Although it is not an uncommon lesion yet in certain conditions it can lead to complications if left untreated. This is a retrospective review of 30 diagnosed odontoma cases from the archives of Department of Oral & Maxillofacial Surgery, Government Dental College & Hospital, Nagpur, India. Out of these 30 cases, 17 were diagnosed as complex odon toma and 13 cases as compound odontoma. Two of these unusual cases have been described which emphasize the importance of early & appropriate treatment to prevent further morbidity.展开更多
目的研究 HOXC13 mRNA 在成秞细胞瘤(ameloblastoma,AB)中的表达,探讨其发生的意义。方法采用原位杂交法检测47例 AB(原发 AB 29例,复发 AB 14例,恶变 AB 4例),同时选取骨纤维异样增殖症2例,牙源性角化囊性瘤(keratocystic odontogenic ...目的研究 HOXC13 mRNA 在成秞细胞瘤(ameloblastoma,AB)中的表达,探讨其发生的意义。方法采用原位杂交法检测47例 AB(原发 AB 29例,复发 AB 14例,恶变 AB 4例),同时选取骨纤维异样增殖症2例,牙源性角化囊性瘤(keratocystic odontogenic tumor,KCOT)10例,正常口腔黏膜上皮7例作对照。结果 HOXC13 mRNA AB 中阳性率为97.9%(46/47),10例 KCOT 中7例为HOXC13 mRNA 阳性表达,但在7例正常口腔黏膜细胞中仅3例为 HOXC13 mRNA 阳性表达,AB、KCOT、正常黏膜三组间差异有统计学意义(X^2=21.665,P=0.001),但角化及颗粒样变退化细胞却为阴性。在部分 AB 间质成纤维细胞质中也有阳性表达,2例骨纤维异常增殖症纤维也为阳性。结论在 AB 中存在 HOXC13的高表达;HOXC13 mRNA 在 AB 上皮中的表达有异质性,该基因可促进上皮的增殖,其丢失可导致上皮细胞的角化和退变。展开更多
文摘Central granular cell odontogenic tumors(CGCOTs)are rare,benign,slowly growing odontogenic neoplasms.Due to their uncertain histogenesis,CGCOTs are still not included as a distinct entity in the WHO classification(2017)of odontogenic tumors.We report a case of CGCOT involving the right side of maxillary anterior region of a 39-year-old white female.Immunohistochemical staining showed that granular cells positively expressed CD68 and vimentin,and negatively expressed S-100 protein.Meanwhile,we searched Pub Med,Google Scholar,and Scopus databases to summary the clinico-pathological features of 51 reported cases of CGCOT.The results showed that the granular cells of 28.6%cases were immunopositive for vimentin and CD68,and odontogenic epithelial cells were positive immunoreactivity for cytokeratin.These findings reinforced the mesenchymal origin of granular cells and the odontogenic nature of epithelium islands.
文摘BACKGROUND Sclerosing odontogenic carcinoma is a rare primary intraosseous neoplasm that was featured recently as a single entity in the World Health Organization classification of Head and Neck Tumors 2017,with only 14 cases published to date.The biological characteristics of sclerosing odontogenic carcinoma remain indistinct because of its rarity;however,it appears to be locally aggressive,with no regional or distant metastasis reported to date.CASE SUMMARY We reported a case of sclerosing odontogenic carcinoma of the maxilla in a 62-year-old woman,who presented with an indolent right palatal swelling,which progressively increased in size over 7 years.Right subtotal maxillectomy with surgical margins of approximately 1.5 cm was performed.The patient remained disease free for 4 years following the ablation surgery.Diagnostic workups,treatment,and therapeutic outcomes were discussed.CONCLUSION More cases are needed to further characterize this entity,understand its biological behavior,and justify the treatment protocols.Resection with wide margins of approximately 1.0 to 1.5 cm is proposed,while neck dissection,post-operative radiotherapy,or chemotherapy are deemed unnecessary.
文摘Ameloblastoma—a benign epithelial odontogenic tumor-histologically occurs in different patterns, the most common of which are plexiform and follicular. “Hybrid” ameloblastoma is a variant in which areas of follicular or plexiform pattern (generally called convention alameloblastoma) coexist with areas of pronounced stromal desmoplasia (desmoplastic ameloblastoma). They most often occur in the mandibular ramus. We present a case of “hybrid” lesion—desmoplastic and conventional ameloblastoma—in the anterior mandible, focusing on its’ imaging features.
文摘Adenomatoid odontogenic tumor is an unusual benign neoplasm which shares clinical and radiographic characteristics with odontogenic cystic lesions denoting a distinct behavior. This paper reports a case of a 12-year-old boy with a bony consistence tumefaction involving the area from teeth 12 to 17. Radiographically, the lesion was characterized by a well-circum- scribed unilocular radiolucent area displacing maxillary canine, first and second premolars. The final diagnosis was adenomatoid odontogenic tumour. The lesion was enucleated concomitantly with the removal of the canine tooth under general anesthesia. The patient was submitted to orthodontic treatment and has been followed-up for four years. Clinical and radiographic features are discussed in this report.
文摘The desmoplastic ameloblastoma (DA) is a rare variant of the conventional ameloblastoma. It accounts for only 4% to 13% of all ameloblastomas. Desmoplastic ameloblastoma (DA) was included in the World Health Organization Classification of Head and Neck Tumors (WHO-2005) as a variant of ameloblastoma with specific clinical, imaging and histological features. The desmoplastic variant of ameloblastoma usually appears in the anterior and premolar regions as a mixed radiolucent and radiopaque lesion, sometimes resembling a benign fibro-osseous lesion [1]. Ameloblastoma is a locally aggressive tumor that may cause recurrence and in rare cases, malignant transformation with repeated postsurgical recurrences [2] [3]. In this paper we present a case of a 47-year-old female with swelling in the left upper jaw, bopsy of which turned out to be desmoplastic ameloblastoma.
文摘Odontoma is a hamartomatous lesion of odontogenic origin involving both epithelial and mesenchymal tissues. Although it is not an uncommon lesion yet in certain conditions it can lead to complications if left untreated. This is a retrospective review of 30 diagnosed odontoma cases from the archives of Department of Oral & Maxillofacial Surgery, Government Dental College & Hospital, Nagpur, India. Out of these 30 cases, 17 were diagnosed as complex odon toma and 13 cases as compound odontoma. Two of these unusual cases have been described which emphasize the importance of early & appropriate treatment to prevent further morbidity.
文摘目的研究 HOXC13 mRNA 在成秞细胞瘤(ameloblastoma,AB)中的表达,探讨其发生的意义。方法采用原位杂交法检测47例 AB(原发 AB 29例,复发 AB 14例,恶变 AB 4例),同时选取骨纤维异样增殖症2例,牙源性角化囊性瘤(keratocystic odontogenic tumor,KCOT)10例,正常口腔黏膜上皮7例作对照。结果 HOXC13 mRNA AB 中阳性率为97.9%(46/47),10例 KCOT 中7例为HOXC13 mRNA 阳性表达,但在7例正常口腔黏膜细胞中仅3例为 HOXC13 mRNA 阳性表达,AB、KCOT、正常黏膜三组间差异有统计学意义(X^2=21.665,P=0.001),但角化及颗粒样变退化细胞却为阴性。在部分 AB 间质成纤维细胞质中也有阳性表达,2例骨纤维异常增殖症纤维也为阳性。结论在 AB 中存在 HOXC13的高表达;HOXC13 mRNA 在 AB 上皮中的表达有异质性,该基因可促进上皮的增殖,其丢失可导致上皮细胞的角化和退变。
