Studies have shown that repetitive transcra nial magnetic stimulation(rTMS)can enhance synaptic plasticity and improve neurological dysfunction.Howeve r,the mechanism through which rTMS can improve moderate traumatic ...Studies have shown that repetitive transcra nial magnetic stimulation(rTMS)can enhance synaptic plasticity and improve neurological dysfunction.Howeve r,the mechanism through which rTMS can improve moderate traumatic brain injury remains poorly understood.In this study,we established rat models of moderate traumatic brain injury using Feeney's weight-dropping method and treated them using rTMS.To help determine the mechanism of action,we measured levels of seve ral impo rtant brain activity-related proteins and their mRNA.On the injured side of the brain,we found that rTMS increased the protein levels and mRNA expression of brain-derived neurotrophic factor,tropomyosin receptor kinase B,N-methyl-D-aspartic acid receptor 1,and phosphorylated cAMP response element binding protein,which are closely associated with the occurrence of long-term potentiation.rTMS also partially reve rsed the loss of synaptophysin after injury and promoted the remodeling of synaptic ultrastructure.These findings suggest that upregulation of synaptic plasticity-related protein expression is the mechanism through which rTMS promotes neurological function recovery after moderate traumatic brain injury.展开更多
Our recent findings have demonstrated that rodent models of closed head traumatic brain injury exhibit comprehensive evidence of progressive and enduring orofacial allodynias, a hypersensitive pain response induced by...Our recent findings have demonstrated that rodent models of closed head traumatic brain injury exhibit comprehensive evidence of progressive and enduring orofacial allodynias, a hypersensitive pain response induced by non-painful stimulation. These allodynias, tested using thermal hyperalgesia, correlated with changes in several known pain signaling receptors and molecules along the trigeminal pain pathway, especially in the trigeminal nucleus caudalis. This study focused to extend our previous work to investigate the changes in monoamine neurotransmitter immunoreactivity changes in spinal trigeminal nucleus oralis, pars interpolaris and nucleus tractus solitaries following mild to moderate closed head traumatic brain injury, which are related to tactile allodynia, touch-pressure sensitivity, and visceral pain. Our results exhibited significant alterations in the excitatory monoamine, serotonin, in spinal trigeminal nucleus oralis and pars interpolaris which usually modulate tactile and mechanical sensitivity in addition to the thermal sensitivity. Moreover, we also detected a robust alteration in the expression of serotonin, and inhibitory molecule norepinephrine in the nucleus tractus solitaries, which might indicate the possibility of an alteration in visceral pain, and existence of other morbidities related to solitary nucleus dysfunction in this rodent model of mild to moderate closed head traumatic brain injury. Collectively, widespread changes in monoamine neurotransmitter may be related to orofacial allodynhias and headache after traumatic brain injury.展开更多
目的:分析格拉斯哥昏迷评分法(Glasgow Coma Scale,GCS)≥8分轻中型脑外伤患者应用醒脑开窍针刺疗法与小脑顶核电刺激联合治疗对患者简易智力状态检查量表(Mini-mental State Examination,MMSE)评分及生活质量的影响。方法:选取2015年9...目的:分析格拉斯哥昏迷评分法(Glasgow Coma Scale,GCS)≥8分轻中型脑外伤患者应用醒脑开窍针刺疗法与小脑顶核电刺激联合治疗对患者简易智力状态检查量表(Mini-mental State Examination,MMSE)评分及生活质量的影响。方法:选取2015年9月-2017年10月我院收治的80例GCS≥8分轻中型脑外伤患者,随机分组进行对照研究,对照组(40例)予以小脑顶核电刺激治疗,观察组(40例)予以醒脑开窍针刺疗法联合小脑顶核电刺激治疗,比较两组总有效率、治疗前后格拉斯哥昏迷评分法(GCS)评分、简易智力状态检查量表(MMSE)评分、生活质量评定表(Quality Of Life,QOL)评分。结果:观察组总有效率90.00%,高于对照组62.50%(P<0.05);观察组治疗后GCS与MMSE评分高于治疗前,且高于对照组(P<0.05);观察组治疗后QOL评分高于对照组(P<0.05)。结论:醒脑开窍针刺疗法联合小脑顶核电刺激可提高GCS≥8分轻中型脑外伤患者MMSE评分与生活质量,改善昏迷状态与认知功能,疗效显著。展开更多
Major Depressive Disorder(MDD)is one of the most popular mental disorders,the treatment of which is far from satisfactory.One present treatment that has emerged is vagus nerve stimulation(VNS),an FDA approved physical...Major Depressive Disorder(MDD)is one of the most popular mental disorders,the treatment of which is far from satisfactory.One present treatment that has emerged is vagus nerve stimulation(VNS),an FDA approved physical treatment for depressive disorders,while the expensive surgery has limited VNS only to patients who have failed to respond to multiple treatment options.展开更多
基金supported by the President Foundation of Nanfang Hospital,Southern Medical University,No.2016Z003(50107021)(to JZF).
文摘Studies have shown that repetitive transcra nial magnetic stimulation(rTMS)can enhance synaptic plasticity and improve neurological dysfunction.Howeve r,the mechanism through which rTMS can improve moderate traumatic brain injury remains poorly understood.In this study,we established rat models of moderate traumatic brain injury using Feeney's weight-dropping method and treated them using rTMS.To help determine the mechanism of action,we measured levels of seve ral impo rtant brain activity-related proteins and their mRNA.On the injured side of the brain,we found that rTMS increased the protein levels and mRNA expression of brain-derived neurotrophic factor,tropomyosin receptor kinase B,N-methyl-D-aspartic acid receptor 1,and phosphorylated cAMP response element binding protein,which are closely associated with the occurrence of long-term potentiation.rTMS also partially reve rsed the loss of synaptophysin after injury and promoted the remodeling of synaptic ultrastructure.These findings suggest that upregulation of synaptic plasticity-related protein expression is the mechanism through which rTMS promotes neurological function recovery after moderate traumatic brain injury.
基金supported by Merit Review Awards(No.B6570R,B78071,and B1005-R)from the United States(U.S.)Department of Veterans Affairs Rehabilitation Research and Development Service
文摘Our recent findings have demonstrated that rodent models of closed head traumatic brain injury exhibit comprehensive evidence of progressive and enduring orofacial allodynias, a hypersensitive pain response induced by non-painful stimulation. These allodynias, tested using thermal hyperalgesia, correlated with changes in several known pain signaling receptors and molecules along the trigeminal pain pathway, especially in the trigeminal nucleus caudalis. This study focused to extend our previous work to investigate the changes in monoamine neurotransmitter immunoreactivity changes in spinal trigeminal nucleus oralis, pars interpolaris and nucleus tractus solitaries following mild to moderate closed head traumatic brain injury, which are related to tactile allodynia, touch-pressure sensitivity, and visceral pain. Our results exhibited significant alterations in the excitatory monoamine, serotonin, in spinal trigeminal nucleus oralis and pars interpolaris which usually modulate tactile and mechanical sensitivity in addition to the thermal sensitivity. Moreover, we also detected a robust alteration in the expression of serotonin, and inhibitory molecule norepinephrine in the nucleus tractus solitaries, which might indicate the possibility of an alteration in visceral pain, and existence of other morbidities related to solitary nucleus dysfunction in this rodent model of mild to moderate closed head traumatic brain injury. Collectively, widespread changes in monoamine neurotransmitter may be related to orofacial allodynhias and headache after traumatic brain injury.
文摘目的:分析格拉斯哥昏迷评分法(Glasgow Coma Scale,GCS)≥8分轻中型脑外伤患者应用醒脑开窍针刺疗法与小脑顶核电刺激联合治疗对患者简易智力状态检查量表(Mini-mental State Examination,MMSE)评分及生活质量的影响。方法:选取2015年9月-2017年10月我院收治的80例GCS≥8分轻中型脑外伤患者,随机分组进行对照研究,对照组(40例)予以小脑顶核电刺激治疗,观察组(40例)予以醒脑开窍针刺疗法联合小脑顶核电刺激治疗,比较两组总有效率、治疗前后格拉斯哥昏迷评分法(GCS)评分、简易智力状态检查量表(MMSE)评分、生活质量评定表(Quality Of Life,QOL)评分。结果:观察组总有效率90.00%,高于对照组62.50%(P<0.05);观察组治疗后GCS与MMSE评分高于治疗前,且高于对照组(P<0.05);观察组治疗后QOL评分高于对照组(P<0.05)。结论:醒脑开窍针刺疗法联合小脑顶核电刺激可提高GCS≥8分轻中型脑外伤患者MMSE评分与生活质量,改善昏迷状态与认知功能,疗效显著。
文摘Major Depressive Disorder(MDD)is one of the most popular mental disorders,the treatment of which is far from satisfactory.One present treatment that has emerged is vagus nerve stimulation(VNS),an FDA approved physical treatment for depressive disorders,while the expensive surgery has limited VNS only to patients who have failed to respond to multiple treatment options.
