The multiple sensing provides booming options to eliminate interference and ensure the accuracy of detection by mutually coupling and validating multiple data sets.Here,we integrate the jigsaw-like multifunctional min...The multiple sensing provides booming options to eliminate interference and ensure the accuracy of detection by mutually coupling and validating multiple data sets.Here,we integrate the jigsaw-like multifunctional mini-pillar platform to perform multi-mode(electrochemical,fluorescence,surface-enhanced Raman scattering(SERS)and colorimetric)sensing in individual microdroplets.Each mini-pillar connector can parallelize together by specific concave-convex interface to form integrated jigsaw-like platform for multi-mode sensing,and each specific mini-pillar can be modified into the individual sensing unit to read the prescribed signals.We successfully implemented electrochemical,fluorescence,SERS and colorimetric detection by multiple signals coupling to reduce the false positive analysis.Such platform brings a promising clue of in-situ analysis and point-of-care testing for disease diagnosis and health monitoring.展开更多
A rapid and cost-effective method for fabricating mini lens arrays is proposed. The lenses are made of silicone oil droplets and filled inside a polydimethylsiloxane(PDMS) elastomer. The lens arrays of different initi...A rapid and cost-effective method for fabricating mini lens arrays is proposed. The lenses are made of silicone oil droplets and filled inside a polydimethylsiloxane(PDMS) elastomer. The lens arrays of different initial focal lengths and apertures can be fabricated by using the droplets of different volumes. Due to good elastic behavior of PDMS, the droplet lenses can be flexibly deformed, and the focal length and numerical aperture can be tuned by applying an external force on the PDMS elastomer. Furthermore, an apparatus for focal length tuning is designed and employed in the imaging system.展开更多
基金National Natural Science Foundation of China(Nos.21804007 and 21890742)Youth Scholars of Beijing Technology and Business University(No.QNJJ2020-04)+1 种基金SZU Top Ranking Project(No.86000000210)Shenzhen Stability Support Plan(No.20200806163622001)。
文摘The multiple sensing provides booming options to eliminate interference and ensure the accuracy of detection by mutually coupling and validating multiple data sets.Here,we integrate the jigsaw-like multifunctional mini-pillar platform to perform multi-mode(electrochemical,fluorescence,surface-enhanced Raman scattering(SERS)and colorimetric)sensing in individual microdroplets.Each mini-pillar connector can parallelize together by specific concave-convex interface to form integrated jigsaw-like platform for multi-mode sensing,and each specific mini-pillar can be modified into the individual sensing unit to read the prescribed signals.We successfully implemented electrochemical,fluorescence,SERS and colorimetric detection by multiple signals coupling to reduce the false positive analysis.Such platform brings a promising clue of in-situ analysis and point-of-care testing for disease diagnosis and health monitoring.
基金supported by the National Key Research and Development Program of China(No.2016YFD0500603)the National Natural Science Foundation of China(Nos.61601292 and 61775140)the Shanghai Science and Technology Commission(Nos.17060502500 and 17JC1400601)
文摘A rapid and cost-effective method for fabricating mini lens arrays is proposed. The lenses are made of silicone oil droplets and filled inside a polydimethylsiloxane(PDMS) elastomer. The lens arrays of different initial focal lengths and apertures can be fabricated by using the droplets of different volumes. Due to good elastic behavior of PDMS, the droplet lenses can be flexibly deformed, and the focal length and numerical aperture can be tuned by applying an external force on the PDMS elastomer. Furthermore, an apparatus for focal length tuning is designed and employed in the imaging system.
