目的:研究在髋臼发育不良(development dysplasia ofhip,DDH)继发骨关节炎患者中,骨盆倾斜与髋臼假体安放角度的关系。方法:2008年1月—2012年12月在复旦大学附属中山医院因DDH继发骨关节炎而行初次全髋关节置换术(total hip arthroplas...目的:研究在髋臼发育不良(development dysplasia ofhip,DDH)继发骨关节炎患者中,骨盆倾斜与髋臼假体安放角度的关系。方法:2008年1月—2012年12月在复旦大学附属中山医院因DDH继发骨关节炎而行初次全髋关节置换术(total hip arthroplasty,THA)的患者353例,将其中89例骨盆倾斜者纳入研究。89例中,脊柱固定畸形者按功能位安放髋臼假体,其他按解剖位置安放髋臼假体。结果:89例中76例患者随访超过1年,术后按功能位测量,平均外展角(41.4±6.5)度;按解剖位测量,平均外展角(37.9±6.3)度。76例均无脱位或感染。1例CrowⅣ型DDH假体移位,术后14个月进行了翻修。结论:骨盆倾斜在全髋关节置换术中是影响髋臼方向的一个重要因素,在安放髋臼假体时应评估未来可能的变化,错误的髋臼方向可能导致髋关节不稳定并增加磨损。展开更多
The novel Coronavirus Disease (nCOVID-19) is a highly contagious viral infection which emerged as “Pneumonia of Unknown Etiology” at Hubei province of Wuhan city in China. The health authorities provided a considera...The novel Coronavirus Disease (nCOVID-19) is a highly contagious viral infection which emerged as “Pneumonia of Unknown Etiology” at Hubei province of Wuhan city in China. The health authorities provided a considerable empirical evidence after this outbreak and it was notified that the causative virus, named Novel Coronavirus (subsequently SARS-CoV-2) is the culprit for progressively exerting grim effects not only on individual patients but also on the International public health, with high mutational tendencies. WHO declared nCOVID-19 as a Pandemic on 11<sup>th</sup> March 2020. The spike glycoprotein of SARS-CoV-2 plays a pivotal role in the entry of virus into the cell and it further interacts with ACE-II receptors which are widely distributed on the human cell surface especially on alveolar type II cells (AT-2) and endothelium. The mortality in nCOVID-19 patients is usually preceded by acute respiratory distress syndrome (ARDS) because of the cytokine storm. Advanced molecular biology and regenerative sciences renders a breakthrough in the treatment of severely ill nCOVID-19 patients with Mesenchymal Stem Cells (MSCs). Autologous or allogenic MSCs attenuate cytokine storm, improvise lung compliance, regulate inflammatory response, maintain functional alveoli microenvironment, promote endogenous regeneration and repair with no or minimal side effects. MSCs are naturally resistant to this novel Coronavirus. Even though it is corroborated with evidences from current clinical trials and pilot study, we emphasize the need for conducting more clinical trials with ethical consideration to prove the efficacy and safety of MSCs in combating nCOVID-19 infection and its complications.展开更多
文摘目的:研究在髋臼发育不良(development dysplasia ofhip,DDH)继发骨关节炎患者中,骨盆倾斜与髋臼假体安放角度的关系。方法:2008年1月—2012年12月在复旦大学附属中山医院因DDH继发骨关节炎而行初次全髋关节置换术(total hip arthroplasty,THA)的患者353例,将其中89例骨盆倾斜者纳入研究。89例中,脊柱固定畸形者按功能位安放髋臼假体,其他按解剖位置安放髋臼假体。结果:89例中76例患者随访超过1年,术后按功能位测量,平均外展角(41.4±6.5)度;按解剖位测量,平均外展角(37.9±6.3)度。76例均无脱位或感染。1例CrowⅣ型DDH假体移位,术后14个月进行了翻修。结论:骨盆倾斜在全髋关节置换术中是影响髋臼方向的一个重要因素,在安放髋臼假体时应评估未来可能的变化,错误的髋臼方向可能导致髋关节不稳定并增加磨损。
文摘The novel Coronavirus Disease (nCOVID-19) is a highly contagious viral infection which emerged as “Pneumonia of Unknown Etiology” at Hubei province of Wuhan city in China. The health authorities provided a considerable empirical evidence after this outbreak and it was notified that the causative virus, named Novel Coronavirus (subsequently SARS-CoV-2) is the culprit for progressively exerting grim effects not only on individual patients but also on the International public health, with high mutational tendencies. WHO declared nCOVID-19 as a Pandemic on 11<sup>th</sup> March 2020. The spike glycoprotein of SARS-CoV-2 plays a pivotal role in the entry of virus into the cell and it further interacts with ACE-II receptors which are widely distributed on the human cell surface especially on alveolar type II cells (AT-2) and endothelium. The mortality in nCOVID-19 patients is usually preceded by acute respiratory distress syndrome (ARDS) because of the cytokine storm. Advanced molecular biology and regenerative sciences renders a breakthrough in the treatment of severely ill nCOVID-19 patients with Mesenchymal Stem Cells (MSCs). Autologous or allogenic MSCs attenuate cytokine storm, improvise lung compliance, regulate inflammatory response, maintain functional alveoli microenvironment, promote endogenous regeneration and repair with no or minimal side effects. MSCs are naturally resistant to this novel Coronavirus. Even though it is corroborated with evidences from current clinical trials and pilot study, we emphasize the need for conducting more clinical trials with ethical consideration to prove the efficacy and safety of MSCs in combating nCOVID-19 infection and its complications.
