目的 检测 SP在单眼剥夺弱视猫 L GN中的表达 ,并探讨其在弱视发病中的意义。方法 采用免疫组化 APA法 ,对 7例正常猫和 8例单眼剥夺弱视猫 L GN SP免疫阳性神经元及神经纤维进行定位并定量研究其变化。结果 在单眼剥夺猫剥夺侧 L GN...目的 检测 SP在单眼剥夺弱视猫 L GN中的表达 ,并探讨其在弱视发病中的意义。方法 采用免疫组化 APA法 ,对 7例正常猫和 8例单眼剥夺弱视猫 L GN SP免疫阳性神经元及神经纤维进行定位并定量研究其变化。结果 在单眼剥夺猫剥夺侧 L GN的A1层 SP表达显著下降 (P <0 .0 5 )。结论 单眼剥夺可造成剥夺侧 L GN剥夺眼相应输入层次的 SP表达下降 。展开更多
The temporal properties of pattern adaptation of relay cells induced by repeated sinusoidal drifting grating were investigated in the dorsal lateral geniculate nucleus (dLGN) of cats. The results showed that the respo...The temporal properties of pattern adaptation of relay cells induced by repeated sinusoidal drifting grating were investigated in the dorsal lateral geniculate nucleus (dLGN) of cats. The results showed that the response amplitude declined and the response latency prolonged when relay cells were pattern-adapted in dLGN, like the similar findings in visual cortex. However, in contrast to the result in cortex, the response phase of relay cells advanced. This implies that an inhibition with relatively long latency may participate in the pattern adaptation of dLGN cells and the adaptation in dLGN may be via a mechanism different from that of visual cortex.展开更多
The action potential （Na<sup>+</sup> spike） of neurons is often followed by a compound after hyperpolarization （AHP） which is mediated by Ca<sup>2+</sup>-dependent K<sup>+</sup>...The action potential （Na<sup>+</sup> spike） of neurons is often followed by a compound after hyperpolarization （AHP） which is mediated by Ca<sup>2+</sup>-dependent K<sup>+</sup> channels. Pyramidal cells in the cerebral cortex are known to have fast, medium and slow AHPs. It is commonly accepted that the fast AHP （fAHP） is mediated by a kind of C- or BK-K<sup>+</sup> channels. The fAHP is characterized by a short duration of about 20 ms, its remarkable voltage dependence and sensitivity to low concentration （【1 mmol/L） of Tetraethylammonium （TEA）.The mAHP results from activation of AHP- or SK-K<sup>+</sup> channels and has a long duration over 200 ms. It is poorly voltage-dependent and blocked by Apamin, but not by TEA.展开更多
It has been demonstrated that the lateral geniculate nucleus (LGN) of the cat possesses two types of inhibitory circuits: feedforward and recurrent inhibitory circuits. The results obtained from brain slice experiment...It has been demonstrated that the lateral geniculate nucleus (LGN) of the cat possesses two types of inhibitory circuits: feedforward and recurrent inhibitory circuits. The results obtained from brain slice experiments have shown that the rat LGN also has the feedforward inhibitory circuit, which mediates an inhibitory postsynaptic potential (IPSP)展开更多
基金the National NaturalScience Foundation of China (Grant Nos. 97908003 and 30070257) the Foundation of the Chinese Academy of Sciences (Grant No. 39893340-03).
文摘The temporal properties of pattern adaptation of relay cells induced by repeated sinusoidal drifting grating were investigated in the dorsal lateral geniculate nucleus (dLGN) of cats. The results showed that the response amplitude declined and the response latency prolonged when relay cells were pattern-adapted in dLGN, like the similar findings in visual cortex. However, in contrast to the result in cortex, the response phase of relay cells advanced. This implies that an inhibition with relatively long latency may participate in the pattern adaptation of dLGN cells and the adaptation in dLGN may be via a mechanism different from that of visual cortex.
文摘The action potential （Na<sup>+</sup> spike） of neurons is often followed by a compound after hyperpolarization （AHP） which is mediated by Ca<sup>2+</sup>-dependent K<sup>+</sup> channels. Pyramidal cells in the cerebral cortex are known to have fast, medium and slow AHPs. It is commonly accepted that the fast AHP （fAHP） is mediated by a kind of C- or BK-K<sup>+</sup> channels. The fAHP is characterized by a short duration of about 20 ms, its remarkable voltage dependence and sensitivity to low concentration （【1 mmol/L） of Tetraethylammonium （TEA）.The mAHP results from activation of AHP- or SK-K<sup>+</sup> channels and has a long duration over 200 ms. It is poorly voltage-dependent and blocked by Apamin, but not by TEA.
基金Project supported by the National Natural Science Foundation of China.
文摘It has been demonstrated that the lateral geniculate nucleus (LGN) of the cat possesses two types of inhibitory circuits: feedforward and recurrent inhibitory circuits. The results obtained from brain slice experiments have shown that the rat LGN also has the feedforward inhibitory circuit, which mediates an inhibitory postsynaptic potential (IPSP)
