目的：研究骨疼静胶囊对热板法致小鼠疼痛及对尾部加压法致小鼠疼痛的影响。方法取体重19～22 g雌性小鼠，随机分组；分别灌服大中小剂量骨疼静胶囊混悬液，颈复康颗粒混悬液和同体积的0,．5％CMC。按热板法及尾部加压法测定小鼠痛阈，...目的：研究骨疼静胶囊对热板法致小鼠疼痛及对尾部加压法致小鼠疼痛的影响。方法取体重19～22 g雌性小鼠，随机分组；分别灌服大中小剂量骨疼静胶囊混悬液，颈复康颗粒混悬液和同体积的0,．5％CMC。按热板法及尾部加压法测定小鼠痛阈，并计算痛阈提高值。结果骨疼静胶囊组和颈复康颗粒组可显著提高小鼠痛阈（ P ＜0．01）；骨疼静胶囊组和颈复康颗粒组可显著提高在小鼠30 min和60min 的压痛痛阈（ P ＜0．01）。结论骨疼静胶囊有显著的镇痛作用。展开更多
OBJECTIVE:To evaluate the effectiveness and safety of cervical spondylosis formula granules in reducing the symptoms of patients with the nerve root type and the vertebral artery type of cervical spondylosis.METHODS:T...OBJECTIVE:To evaluate the effectiveness and safety of cervical spondylosis formula granules in reducing the symptoms of patients with the nerve root type and the vertebral artery type of cervical spondylosis.METHODS:This was a multicenter, single-blind,randomized, controlled trial.From April 2002 to November 2003, 499 patients were randomly assigned to either the treatment or the control group.The treatment group was orally administered granules prepared with a formula for cervical spondylosis, while the control group was given Jingfukang granules.The treatment course was 1 month for both groups.RESULTS:In patients with the nerve root type of cervical spondylosis, the total effect rate in the treatment group(87.21%) was significantly higher than that in the control group(80.70%, P < 0.01).After the treatment period in both groups, the treatment group had a significantly greater rate of resolution of pain, numbness of the upper limbs, muscle strength of the upper limbs, and fatigue than the control group(all P < 0.05).In patients with the vertebral artery type of cervical spondylosis, the total effect rate in the treatment group(82.07%) was similar to that in the control group(71.21%, P >0.05).After the treatment period in both groups,the treatment group had a significantly greater rate of resolution of weakness of the waist and knees than the control group(P < 0.05).CONCLUSION:The cervical spondylosis formula granules significantly improve numbness, muscle strength, and fatigue, and reduce pain in patients with the nerve root type of cervical spondylosis,and improve the weakness of the waist and knees in patients with the vertebral artery type of cervical spondylosis.展开更多
文摘目的：研究骨疼静胶囊对热板法致小鼠疼痛及对尾部加压法致小鼠疼痛的影响。方法取体重19～22 g雌性小鼠，随机分组；分别灌服大中小剂量骨疼静胶囊混悬液，颈复康颗粒混悬液和同体积的0,．5％CMC。按热板法及尾部加压法测定小鼠痛阈，并计算痛阈提高值。结果骨疼静胶囊组和颈复康颗粒组可显著提高小鼠痛阈（ P ＜0．01）；骨疼静胶囊组和颈复康颗粒组可显著提高在小鼠30 min和60min 的压痛痛阈（ P ＜0．01）。结论骨疼静胶囊有显著的镇痛作用。
文摘OBJECTIVE:To evaluate the effectiveness and safety of cervical spondylosis formula granules in reducing the symptoms of patients with the nerve root type and the vertebral artery type of cervical spondylosis.METHODS:This was a multicenter, single-blind,randomized, controlled trial.From April 2002 to November 2003, 499 patients were randomly assigned to either the treatment or the control group.The treatment group was orally administered granules prepared with a formula for cervical spondylosis, while the control group was given Jingfukang granules.The treatment course was 1 month for both groups.RESULTS:In patients with the nerve root type of cervical spondylosis, the total effect rate in the treatment group(87.21%) was significantly higher than that in the control group(80.70%, P < 0.01).After the treatment period in both groups, the treatment group had a significantly greater rate of resolution of pain, numbness of the upper limbs, muscle strength of the upper limbs, and fatigue than the control group(all P < 0.05).In patients with the vertebral artery type of cervical spondylosis, the total effect rate in the treatment group(82.07%) was similar to that in the control group(71.21%, P >0.05).After the treatment period in both groups,the treatment group had a significantly greater rate of resolution of weakness of the waist and knees than the control group(P < 0.05).CONCLUSION:The cervical spondylosis formula granules significantly improve numbness, muscle strength, and fatigue, and reduce pain in patients with the nerve root type of cervical spondylosis,and improve the weakness of the waist and knees in patients with the vertebral artery type of cervical spondylosis.
