Interleukin-17(IL-17)and IL-17-producing cells have been shown to play important roles in inflammation and the immune response.IL-17 is believed to be mainly produced by T helper 17(Th17)cells,a unique helper T-cell s...Interleukin-17(IL-17)and IL-17-producing cells have been shown to play important roles in inflammation and the immune response.IL-17 is believed to be mainly produced by T helper 17(Th17)cells,a unique helper T-cell subset different from Th1 and Th2 cells.Other subsets of T cells such as cdT and natural killer T(NKT)cells have also been found to produce IL-17 in response to innate stimuli.IL-17 acts as a proinflammatory cytokine that can induce the release of certain chemokines,cytokines,matrix metalloproteinases(MMPs)and antimicrobial peptides from mesenchymal and myeloid cells.This leads to the expansion and accumulation of neutrophils in the innate immune system and links innate and adaptive immunity in vivo.Furthermore,increasing evidence indicates that IL-17 and IL-17-producing cells are involved in the pathogenesis of various diseases such as allergies,autoimmune diseases,allograft transplantation and even malignancy.They may also play protective roles in host defense against infectious diseases and promote induction of cytotoxic T lymphocyte(CTL)responses against cancer.Targeting of the IL-17 axis is under investigation for the treatment of inflammatory disorders.展开更多
The etiopathology of inflammatory bowel disease （IBD） remains elusive. Accumulating evidence suggests that the abnormality of innate and adaptive immunity responses plays an important role in intestinal inflam- mati...The etiopathology of inflammatory bowel disease （IBD） remains elusive. Accumulating evidence suggests that the abnormality of innate and adaptive immunity responses plays an important role in intestinal inflam- mation. IBD including Crohn＇s disease （CD） and ulcerative colitis （UC） is a chronic inflammatory disease of the gastrointestinal tract, which is implicated in an inappropriate and overactive mucosal immune response to luminal flora. Traditionally, CD is regarded as a Thl- mediated inflammatory disorder while UC is regarded as a Th2-1ike disease. Recently, Th17 cells were identified as a new subset of T helper cells unrelated to Thl or Th2 cells, and several cytokines [e.g. interleukin （IL）-21, IL-23] are involved in regulating their activation and differentiation. They not only play an important role in host defense against extracellular pathogens, but are also associated with the development of autoimmunity and inflammatory response such as IBD. The identification of Th17 cells helps us to explain some of the anomalies seen in the Thl/Th2 axis and has broadened our understanding of the immunopathological effects of Th17 cells in the development of IBD.展开更多
目的探讨细胞因子IL-17、IL-23、IL-22、IL-11在溃疡性结肠炎（UC）患者肠道黏膜中的表达及临床意义。方法选取2008年1月~2015年1月于南方医院消化科就诊的活动期UC患者40例,缓解期UC患者15例,健康对照组15例,运用免疫组织化学法检测上...目的探讨细胞因子IL-17、IL-23、IL-22、IL-11在溃疡性结肠炎（UC）患者肠道黏膜中的表达及临床意义。方法选取2008年1月~2015年1月于南方医院消化科就诊的活动期UC患者40例,缓解期UC患者15例,健康对照组15例,运用免疫组织化学法检测上述70例入选者肠黏膜活检组织中IL-17、IL-23、IL-22、IL-11的表达与分布。进一步收集40例经规范化治疗并且定期随访的活动期UC患者,根据规范化治疗2月后内镜下黏膜愈合情况分为黏膜愈合良好组和预后欠佳组,比较上述细胞因子在两组间治疗前肠道黏膜中的表达。结果活动期UC患者肠黏膜组织IL-17、IL-23、IL-22、IL-11的表达均明显高于缓解UC组和健康对照组（分别为0.0727±0.0037 vs 0.0354±0.0243 vs 0.0330±0.0045;0.1407±0.0068 vs 0.0865±0.0051 vs 0.0442±0.0137;0.0522±0.0045 vs 0.0259±0.0063 vs 0.0115±0.0061;0.0479±0.0022 vs 0.0365±0.0024 vs 0.0232±0.0009）（P〈0.05）。IL-17、IL-23、IL-22在肠黏膜中表达水平随疾病活动度增加而增加（分别为：0.0545±0.0072 vs 0.0786±0.0051 vs 0.0847±0.0197;0.1112±0.0046 vs 0.1480±0.0089 vs 0.1644±0.0190;0.0307±0.0063 vs 0.0548±0.0071 vs 0.0719±0.0056）（P〈0.05）。IL-17、IL-23、IL-22、IL-11表达水平,与内镜下活动度分级均呈正相关（P〈0.05）,其中IL-17、IL-22表达水平,与病理组织学分级亦呈正相关（P〈0.05）。此外,各炎性细胞因子相互之间的表达水平均呈正相关。IL-17高表达组的黏膜愈合欠佳率（66.67%）较低表达组（25.00%）的显著增高（P〈0.05）。结论 IL-17、IL-23、IL-22、IL-11在溃疡性结肠炎的发病发展中均发挥一定作用,可一定程度上评估患者病情的严重程度,IL-17的表达水平可能对短期治疗后黏膜愈合的预后预测有一定参考价值。展开更多
目的探讨丁苯酞对急性脑梗死患者血清炎症因子与氧化应激水平的影响。方法选取2014年3月—2016年9月我院神经内科收治的急性脑梗死患者120例,根据治疗方法的不同分为常规治疗组(56例)和丁苯酞组(64例)。常规治疗组给予抗血小板聚集、改...目的探讨丁苯酞对急性脑梗死患者血清炎症因子与氧化应激水平的影响。方法选取2014年3月—2016年9月我院神经内科收治的急性脑梗死患者120例,根据治疗方法的不同分为常规治疗组(56例)和丁苯酞组(64例)。常规治疗组给予抗血小板聚集、改善微循环等常规治疗,丁苯酞组在常规治疗的基础上加用丁苯酞注射液治疗(100 m L静脉滴注,每日2次)。分别检测患者入院时,治疗7 d、14 d的血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、IL-17、IL-23和氧化应激产物丙二醛(MDA)的水平,并评价其临床疗效。结果治疗后第7天及第14天,2组患者血清TNF-α、IL-6、IL-17、IL-23,MDA水平均较治疗前下降,差异均有统计学意义(P<0.05),同时丁苯酞组上述指标均较常规治疗组下降(P<0.05)。2组均未出现明显的不良反应。结论丁苯酞可通过抑制炎症反应和对抗氧化应激等方面来改善急性脑梗死患者的临床症状,改善预后。展开更多
文摘Interleukin-17(IL-17)and IL-17-producing cells have been shown to play important roles in inflammation and the immune response.IL-17 is believed to be mainly produced by T helper 17(Th17)cells,a unique helper T-cell subset different from Th1 and Th2 cells.Other subsets of T cells such as cdT and natural killer T(NKT)cells have also been found to produce IL-17 in response to innate stimuli.IL-17 acts as a proinflammatory cytokine that can induce the release of certain chemokines,cytokines,matrix metalloproteinases(MMPs)and antimicrobial peptides from mesenchymal and myeloid cells.This leads to the expansion and accumulation of neutrophils in the innate immune system and links innate and adaptive immunity in vivo.Furthermore,increasing evidence indicates that IL-17 and IL-17-producing cells are involved in the pathogenesis of various diseases such as allergies,autoimmune diseases,allograft transplantation and even malignancy.They may also play protective roles in host defense against infectious diseases and promote induction of cytotoxic T lymphocyte(CTL)responses against cancer.Targeting of the IL-17 axis is under investigation for the treatment of inflammatory disorders.
基金Supported by Grants From the National Natural Science Foundation of China,No.30770988 and No.30971358
文摘The etiopathology of inflammatory bowel disease （IBD） remains elusive. Accumulating evidence suggests that the abnormality of innate and adaptive immunity responses plays an important role in intestinal inflam- mation. IBD including Crohn＇s disease （CD） and ulcerative colitis （UC） is a chronic inflammatory disease of the gastrointestinal tract, which is implicated in an inappropriate and overactive mucosal immune response to luminal flora. Traditionally, CD is regarded as a Thl- mediated inflammatory disorder while UC is regarded as a Th2-1ike disease. Recently, Th17 cells were identified as a new subset of T helper cells unrelated to Thl or Th2 cells, and several cytokines [e.g. interleukin （IL）-21, IL-23] are involved in regulating their activation and differentiation. They not only play an important role in host defense against extracellular pathogens, but are also associated with the development of autoimmunity and inflammatory response such as IBD. The identification of Th17 cells helps us to explain some of the anomalies seen in the Thl/Th2 axis and has broadened our understanding of the immunopathological effects of Th17 cells in the development of IBD.
文摘目的探讨细胞因子IL-17、IL-23、IL-22、IL-11在溃疡性结肠炎（UC）患者肠道黏膜中的表达及临床意义。方法选取2008年1月~2015年1月于南方医院消化科就诊的活动期UC患者40例,缓解期UC患者15例,健康对照组15例,运用免疫组织化学法检测上述70例入选者肠黏膜活检组织中IL-17、IL-23、IL-22、IL-11的表达与分布。进一步收集40例经规范化治疗并且定期随访的活动期UC患者,根据规范化治疗2月后内镜下黏膜愈合情况分为黏膜愈合良好组和预后欠佳组,比较上述细胞因子在两组间治疗前肠道黏膜中的表达。结果活动期UC患者肠黏膜组织IL-17、IL-23、IL-22、IL-11的表达均明显高于缓解UC组和健康对照组（分别为0.0727±0.0037 vs 0.0354±0.0243 vs 0.0330±0.0045;0.1407±0.0068 vs 0.0865±0.0051 vs 0.0442±0.0137;0.0522±0.0045 vs 0.0259±0.0063 vs 0.0115±0.0061;0.0479±0.0022 vs 0.0365±0.0024 vs 0.0232±0.0009）（P〈0.05）。IL-17、IL-23、IL-22在肠黏膜中表达水平随疾病活动度增加而增加（分别为：0.0545±0.0072 vs 0.0786±0.0051 vs 0.0847±0.0197;0.1112±0.0046 vs 0.1480±0.0089 vs 0.1644±0.0190;0.0307±0.0063 vs 0.0548±0.0071 vs 0.0719±0.0056）（P〈0.05）。IL-17、IL-23、IL-22、IL-11表达水平,与内镜下活动度分级均呈正相关（P〈0.05）,其中IL-17、IL-22表达水平,与病理组织学分级亦呈正相关（P〈0.05）。此外,各炎性细胞因子相互之间的表达水平均呈正相关。IL-17高表达组的黏膜愈合欠佳率（66.67%）较低表达组（25.00%）的显著增高（P〈0.05）。结论 IL-17、IL-23、IL-22、IL-11在溃疡性结肠炎的发病发展中均发挥一定作用,可一定程度上评估患者病情的严重程度,IL-17的表达水平可能对短期治疗后黏膜愈合的预后预测有一定参考价值。
文摘目的探讨丁苯酞对急性脑梗死患者血清炎症因子与氧化应激水平的影响。方法选取2014年3月—2016年9月我院神经内科收治的急性脑梗死患者120例,根据治疗方法的不同分为常规治疗组(56例)和丁苯酞组(64例)。常规治疗组给予抗血小板聚集、改善微循环等常规治疗,丁苯酞组在常规治疗的基础上加用丁苯酞注射液治疗(100 m L静脉滴注,每日2次)。分别检测患者入院时,治疗7 d、14 d的血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、IL-17、IL-23和氧化应激产物丙二醛(MDA)的水平,并评价其临床疗效。结果治疗后第7天及第14天,2组患者血清TNF-α、IL-6、IL-17、IL-23,MDA水平均较治疗前下降,差异均有统计学意义(P<0.05),同时丁苯酞组上述指标均较常规治疗组下降(P<0.05)。2组均未出现明显的不良反应。结论丁苯酞可通过抑制炎症反应和对抗氧化应激等方面来改善急性脑梗死患者的临床症状,改善预后。
