Vascular endothelial growth factor receptor 2(VEGFR-2)and neuropilin-1(NRP-1)are two prominent antiangiogenic targets.They are highly expressed on vascular endothelial cells and some tumor cells.Therefore,targeting VE...Vascular endothelial growth factor receptor 2(VEGFR-2)and neuropilin-1(NRP-1)are two prominent antiangiogenic targets.They are highly expressed on vascular endothelial cells and some tumor cells.Therefore,targeting VEGFR-2 and NRP-1 may be a potential antiangiogenic and antitumor strategy.A7R,a peptide with sequence of Ala-Thr-Trp-Leu-Pro-Pro-Arg that was found by phage display of peptide libraries,can preferentially target VEGFR-2 and NRP-1 and destroy the binding between vascular endothelial growth factor 165(VEGF165)and VEGFR-2 or NRP-1.This peptide is a new potent inhibitor of tumor angiogenesis and a targeting ligand for cancer therapy.This review describes the discovery,function and mechanism of the action of A7R,and further introduces the applications of A7R in antitumor angiogenic treatments,tumor angiogenesis imaging and targeted drug delivery systems.In this review,strategies to deliver different drugs by A7R-modified liposomes and nanoparticles are highlighted.A7R,a new dual targeting ligand of VEGFR-2 and NRP-1,is expected to have efficient therapeutic or targeting roles in tumor drug delivery.展开更多
Photoacoustic mesoscopy(PAMe) offers high-sensitivity in vivo imaging based on the rich optical contrast in biological tissues,with sub-100-micron resolutions at a few millimeters depth. By benefiting from low ultraso...Photoacoustic mesoscopy(PAMe) offers high-sensitivity in vivo imaging based on the rich optical contrast in biological tissues,with sub-100-micron resolutions at a few millimeters depth. By benefiting from low ultrasonic scattering,this emerging technology has pushed the penetration depth beyond the optical diffuse limit unprecedented for high-resolution optical methods.Here,we review ed the state-of-art implementations of PAMe and their achievements in biological and primary clinical applications. With the high-frequency focused ultrasonic detector,the high-resolution optical visualization can be achieved by utilizing various PAMe systems. These capabilities of PAMe have made it well applicable for understanding the biological mechanisms,exploring the pathological features and analyzing the characteristics of human skin. Future improvements and prospects of PAMe are also mentioned,suggesting its great potential tow ards the corresponding emerging biomedical and clinical applications.展开更多
目的三维超声造影(three-dimensional contrast-enhanced ultrasound,3D-CEUS)是一种新型成像技术,可用于评估肿瘤的血供、内部结构及其边界。探讨3D-CEUS在肾肿瘤中的应用价值。方法对35例肾肿瘤患者行三维彩色血管能量成像(three-dime...目的三维超声造影(three-dimensional contrast-enhanced ultrasound,3D-CEUS)是一种新型成像技术,可用于评估肿瘤的血供、内部结构及其边界。探讨3D-CEUS在肾肿瘤中的应用价值。方法对35例肾肿瘤患者行三维彩色血管能量成像(three-dimensional color power angiography,3D-CPA),二维超声造影(two-dimensional contrast-enhanced ultrasound,2D-CEUS)检查后再行3D-CEUS检查。重建三维图像后利用后处理软件观察病灶的血管特征,对比2种三维成像技术对肾肿瘤滋养血管的显示率。结果3D-CEUS成像时,皮质相早期采集获知病灶的滋养动脉及起始强化部位,皮质相肾皮质强化后采集显示瘤灶的强化程度及方式,延迟相采集清晰显示瘤灶境界、坏死灶范围。3D-CEUS/3D-CPA对同组肾肿瘤滋养血管的显示率为82.86%/51.43%。结论3D-CEUS可有效评估肾肿瘤的血供情况,为临床提供更丰富的信息。展开更多
基金funded by National Natural Science Foundation of China(No.81302686)Primary Research&Developement Plan of Shandong Province(No.2016GSF201083)
文摘Vascular endothelial growth factor receptor 2(VEGFR-2)and neuropilin-1(NRP-1)are two prominent antiangiogenic targets.They are highly expressed on vascular endothelial cells and some tumor cells.Therefore,targeting VEGFR-2 and NRP-1 may be a potential antiangiogenic and antitumor strategy.A7R,a peptide with sequence of Ala-Thr-Trp-Leu-Pro-Pro-Arg that was found by phage display of peptide libraries,can preferentially target VEGFR-2 and NRP-1 and destroy the binding between vascular endothelial growth factor 165(VEGF165)and VEGFR-2 or NRP-1.This peptide is a new potent inhibitor of tumor angiogenesis and a targeting ligand for cancer therapy.This review describes the discovery,function and mechanism of the action of A7R,and further introduces the applications of A7R in antitumor angiogenic treatments,tumor angiogenesis imaging and targeted drug delivery systems.In this review,strategies to deliver different drugs by A7R-modified liposomes and nanoparticles are highlighted.A7R,a new dual targeting ligand of VEGFR-2 and NRP-1,is expected to have efficient therapeutic or targeting roles in tumor drug delivery.
基金the National Natural Science Foundation of China (Grant Nos.81401453,81371602,61475115,61475116,61575140,81571723,and 81671728)the Tianjin Municipal Government of China (Grant Nos.14JCQNJC14400,15JCZDJC31800,15JCQNJC14500,and 16JCZDJC31200)
文摘Photoacoustic mesoscopy(PAMe) offers high-sensitivity in vivo imaging based on the rich optical contrast in biological tissues,with sub-100-micron resolutions at a few millimeters depth. By benefiting from low ultrasonic scattering,this emerging technology has pushed the penetration depth beyond the optical diffuse limit unprecedented for high-resolution optical methods.Here,we review ed the state-of-art implementations of PAMe and their achievements in biological and primary clinical applications. With the high-frequency focused ultrasonic detector,the high-resolution optical visualization can be achieved by utilizing various PAMe systems. These capabilities of PAMe have made it well applicable for understanding the biological mechanisms,exploring the pathological features and analyzing the characteristics of human skin. Future improvements and prospects of PAMe are also mentioned,suggesting its great potential tow ards the corresponding emerging biomedical and clinical applications.
文摘目的三维超声造影(three-dimensional contrast-enhanced ultrasound,3D-CEUS)是一种新型成像技术,可用于评估肿瘤的血供、内部结构及其边界。探讨3D-CEUS在肾肿瘤中的应用价值。方法对35例肾肿瘤患者行三维彩色血管能量成像(three-dimensional color power angiography,3D-CPA),二维超声造影(two-dimensional contrast-enhanced ultrasound,2D-CEUS)检查后再行3D-CEUS检查。重建三维图像后利用后处理软件观察病灶的血管特征,对比2种三维成像技术对肾肿瘤滋养血管的显示率。结果3D-CEUS成像时,皮质相早期采集获知病灶的滋养动脉及起始强化部位,皮质相肾皮质强化后采集显示瘤灶的强化程度及方式,延迟相采集清晰显示瘤灶境界、坏死灶范围。3D-CEUS/3D-CPA对同组肾肿瘤滋养血管的显示率为82.86%/51.43%。结论3D-CEUS可有效评估肾肿瘤的血供情况,为临床提供更丰富的信息。
