AIM To elucidate the effects of small intestinal bacterial overgrowth(SIBO) on the severity and complications of acute pancreatitis(AP).METHODS In total,208 patients with AP as defined by the revised Atlanta classific...AIM To elucidate the effects of small intestinal bacterial overgrowth(SIBO) on the severity and complications of acute pancreatitis(AP).METHODS In total,208 patients with AP as defined by the revised Atlanta classification were admitted to Xuanwu Hospital of capital Medical University from 2013 to 2016. All patients were admitted within 72 h of AP onset. The hydrogen breath test was performed 7 d after AP onset to detect hydrogen production and evaluate the development of SIBO. The incidence of SIBO was analyzed in patients with AP of three different severity grades. The association between SIBO and complications of AP was also assessed.RESULTS Of the 27 patients with severe AP(SAP),seven(25.92%) developed SIBO. Of the 86 patients with moderately severe AP(MSAP),22(25.58%) developed SIBO. Of the 95 patients with mild AP(MAP),eight(8.42%) developed SIBO. There were significant differences in the rates of SIBO among patients with AP of different severities. Additionally,more severe APwas associated with higher rates of SIBO positivity(P < 0.05). SIBO in patients with AP mainly occurred within 72 h of the onset of AP. The incidence of organ failure was significantly higher in patients with SIBO than in those without(P < 0.05).CONCLUSION SIBO occurs more frequently in patients with MSAP or SAP than in those with MAP,usually ≤ 72 h after AP onset. Additionally,SIBO is associated with organ failure.展开更多
目的研究恶性梗阻性黄疸患者围手术期血浆内毒素(PE)的动态变化,应用呼气氢试验(HBT)判断小肠细菌的移位及其意义。方法选择38例可行手术治疗的恶性梗阻性黄疸患者为试验组(A组),健康受试者30例为对照组(B组)。观察A组患者术前、术后PE...目的研究恶性梗阻性黄疸患者围手术期血浆内毒素(PE)的动态变化,应用呼气氢试验(HBT)判断小肠细菌的移位及其意义。方法选择38例可行手术治疗的恶性梗阻性黄疸患者为试验组(A组),健康受试者30例为对照组(B组)。观察A组患者术前、术后PE的变化及HBT的结果,并与B组进行比较。结果入院时A组PE水平为(0.69±0.22)EU/mL(Endotoxin Unit per mL),与B组(0.17±0.05)EU/mL相比差异有显著性(P<0.01);A组术前1d PE下降不明显(P>0.05),术后下降显著(P<0.05)。A组入院时,术前1 d,术后3,7,14 d HBT阳性率分别为86.8%,73.7%,39.5%,21.1%和7.9%;B组阳性率为6.7%。A组入院时与B组相比差异有显著性(P<0.05)。A组术后3,7 d与术前1d相比较差异有显著性(P<0.05)。结论恶性梗阻性黄疸患者存在肠道细菌移位,合并不同程度的内毒素血症。展开更多
Small intestinal bacterial overgrowth has been found to be associated with a variety of gastrointestinal disorders such as irritable bowel syndrome, inflammatory bowel disease, and, in recent years, diabetes mellitus ...Small intestinal bacterial overgrowth has been found to be associated with a variety of gastrointestinal disorders such as irritable bowel syndrome, inflammatory bowel disease, and, in recent years, diabetes mellitus and systemic sclerosis, among other extraintestinal diseases. Several novel diagnostic tools for small intestinal bacterial overgrowth have emerged in recent years, and several therapeutic approaches have been proposed. Therefore, it has become necessary to find an effective, safe, and simple diagnostic method and a safe treatment modality. This article provides a review of current diagnostic and therapeutic approaches to small intestinal bacterial overgrowth.展开更多
基金Supported by Wu Jieping Medical Foundation,No.320.6750.12120
文摘AIM To elucidate the effects of small intestinal bacterial overgrowth(SIBO) on the severity and complications of acute pancreatitis(AP).METHODS In total,208 patients with AP as defined by the revised Atlanta classification were admitted to Xuanwu Hospital of capital Medical University from 2013 to 2016. All patients were admitted within 72 h of AP onset. The hydrogen breath test was performed 7 d after AP onset to detect hydrogen production and evaluate the development of SIBO. The incidence of SIBO was analyzed in patients with AP of three different severity grades. The association between SIBO and complications of AP was also assessed.RESULTS Of the 27 patients with severe AP(SAP),seven(25.92%) developed SIBO. Of the 86 patients with moderately severe AP(MSAP),22(25.58%) developed SIBO. Of the 95 patients with mild AP(MAP),eight(8.42%) developed SIBO. There were significant differences in the rates of SIBO among patients with AP of different severities. Additionally,more severe APwas associated with higher rates of SIBO positivity(P < 0.05). SIBO in patients with AP mainly occurred within 72 h of the onset of AP. The incidence of organ failure was significantly higher in patients with SIBO than in those without(P < 0.05).CONCLUSION SIBO occurs more frequently in patients with MSAP or SAP than in those with MAP,usually ≤ 72 h after AP onset. Additionally,SIBO is associated with organ failure.
文摘目的研究恶性梗阻性黄疸患者围手术期血浆内毒素(PE)的动态变化,应用呼气氢试验(HBT)判断小肠细菌的移位及其意义。方法选择38例可行手术治疗的恶性梗阻性黄疸患者为试验组(A组),健康受试者30例为对照组(B组)。观察A组患者术前、术后PE的变化及HBT的结果,并与B组进行比较。结果入院时A组PE水平为(0.69±0.22)EU/mL(Endotoxin Unit per mL),与B组(0.17±0.05)EU/mL相比差异有显著性(P<0.01);A组术前1d PE下降不明显(P>0.05),术后下降显著(P<0.05)。A组入院时,术前1 d,术后3,7,14 d HBT阳性率分别为86.8%,73.7%,39.5%,21.1%和7.9%;B组阳性率为6.7%。A组入院时与B组相比差异有显著性(P<0.05)。A组术后3,7 d与术前1d相比较差异有显著性(P<0.05)。结论恶性梗阻性黄疸患者存在肠道细菌移位,合并不同程度的内毒素血症。
文摘Small intestinal bacterial overgrowth has been found to be associated with a variety of gastrointestinal disorders such as irritable bowel syndrome, inflammatory bowel disease, and, in recent years, diabetes mellitus and systemic sclerosis, among other extraintestinal diseases. Several novel diagnostic tools for small intestinal bacterial overgrowth have emerged in recent years, and several therapeutic approaches have been proposed. Therefore, it has become necessary to find an effective, safe, and simple diagnostic method and a safe treatment modality. This article provides a review of current diagnostic and therapeutic approaches to small intestinal bacterial overgrowth.
