Background:The 2019 novel coronavirus(2019-nCoV)causing an outbreak of pneumonia in Wuhan,Hubei province of China was isolated in January 2020.This study aims to investigate its epidemiologic history,and analyze the c...Background:The 2019 novel coronavirus(2019-nCoV)causing an outbreak of pneumonia in Wuhan,Hubei province of China was isolated in January 2020.This study aims to investigate its epidemiologic history,and analyze the clinical characteristics,treatment regimens,and prognosis of patients infected with 2019-nCoV during this outbreak.Methods:Clinical data from 1372019-nCoV-infected patients admitted to the respiratory departments of nine tertiary hospitals in Hubei province from December 30,2019 to January 24,2020 were retrospectively collected,including general status,clinical manifestations,laboratory test results,imaging characteristics,and treatment regimens.Results:None of the 137 patients(61 males,76 females,aged 20-83 years,median age 57 years)had a definite history of exposure to Huanan Seafood Wholesale Market.Major initial symptoms included fever(112/137,81.8%),coughing(66/137,48.2%),and muscle pain or fatigue(44/137,32.1%),with other,less typical initial symptoms observed at low frequency,including heart palpitations,diarrhea,and headache.Nearly 80%of the patients had normal or decreased white blood cell counts,and 72.3%(99/137)had lymphocytopenia.Lung involvement was present in all cases,with most chest computed tomography scans showing lesions in multiple lung lobes,some of which were dense;ground-glass opacity co-existed with consolidation shadows or cord-like shadows.Given the lack of effective drugs,treatment focused on symptomatic and respiratory support.Immunoglobulin G was delivered to some critically ill patients according to their conditions.Systemic corticosteroid treatment did not show significant benefits.Notably,early respiratory support facilitated disease recovery and improved prognosis.The risk of death was primarily associated with age,underlying chronic diseases,and median interval from the appearance of initial symptoms to dyspnea.Conclusions:The majority of patients with 2019-nCoV pneumonia present with fever as the first symptom,and most of them still showed typical manifestations of v展开更多
Background:An outbreak of 2019 novel coronavirus diseases(COVID-19)in Wuhan,Hubei Province,China has spread quickly nationwide.Here,we report results of a descriptive,exploratory analysis of all cases diagnosed as of ...Background:An outbreak of 2019 novel coronavirus diseases(COVID-19)in Wuhan,Hubei Province,China has spread quickly nationwide.Here,we report results of a descriptive,exploratory analysis of all cases diagnosed as of February 11,2020.Methods:All COVID-19 cases reported through February 11,2020 were extracted from China’s Infectious Disease Information System.Analyses included the following:(1)summary of patient characteristics;(2)examination of age distributions and sex ratios;(3)calculation of case fatality and mortality rates;(4)geo-temporal analysis of viral spread;(5)epidemiological curve construction;and (6)subgroup analysis.Results:A total of 72,314 patient records—44,672(61.8%)confirmed cases,16,186(22.4%)suspected cases,10,567(14.6%)clinically diagnosed cases(Hubei Province only),and 889 asymptomatic cases(1.2%)-contributed data for the analysis.Among confirmed cases,most were aged 30–79 years(86.6%),diagnosed in Hubei(74.7%),and considered mild(80.9%).A total of 1,023 deaths occurred among confirmed cases for an overall case fatality rate of 2.3%.The COVID-19 spread outward from Hubei Province sometime after December 2019,and by February 11,2020,1,386 counties across all 31 provinces were affected.The epidemic curve of onset of symptoms peaked around January 23–26,then began to decline leading up to February 11.A total of 1,716 health workers have become infected and 5 have died(0.3%).Conclusions:COVID-19 epidemic has spread very quickly taking only 30 days to expand from Hubei to the rest of China's Mainland.With many people returning from a long holiday,China needs to prepare for the possible rebound of the epidemic.展开更多
文摘Background:The 2019 novel coronavirus(2019-nCoV)causing an outbreak of pneumonia in Wuhan,Hubei province of China was isolated in January 2020.This study aims to investigate its epidemiologic history,and analyze the clinical characteristics,treatment regimens,and prognosis of patients infected with 2019-nCoV during this outbreak.Methods:Clinical data from 1372019-nCoV-infected patients admitted to the respiratory departments of nine tertiary hospitals in Hubei province from December 30,2019 to January 24,2020 were retrospectively collected,including general status,clinical manifestations,laboratory test results,imaging characteristics,and treatment regimens.Results:None of the 137 patients(61 males,76 females,aged 20-83 years,median age 57 years)had a definite history of exposure to Huanan Seafood Wholesale Market.Major initial symptoms included fever(112/137,81.8%),coughing(66/137,48.2%),and muscle pain or fatigue(44/137,32.1%),with other,less typical initial symptoms observed at low frequency,including heart palpitations,diarrhea,and headache.Nearly 80%of the patients had normal or decreased white blood cell counts,and 72.3%(99/137)had lymphocytopenia.Lung involvement was present in all cases,with most chest computed tomography scans showing lesions in multiple lung lobes,some of which were dense;ground-glass opacity co-existed with consolidation shadows or cord-like shadows.Given the lack of effective drugs,treatment focused on symptomatic and respiratory support.Immunoglobulin G was delivered to some critically ill patients according to their conditions.Systemic corticosteroid treatment did not show significant benefits.Notably,early respiratory support facilitated disease recovery and improved prognosis.The risk of death was primarily associated with age,underlying chronic diseases,and median interval from the appearance of initial symptoms to dyspnea.Conclusions:The majority of patients with 2019-nCoV pneumonia present with fever as the first symptom,and most of them still showed typical manifestations of v
基金supported by National Science and Technology Foundation of China(2018ZX10201002-008-002),and by National Nature Science Foundation of China(NSFC,71934002).
文摘Background:An outbreak of 2019 novel coronavirus diseases(COVID-19)in Wuhan,Hubei Province,China has spread quickly nationwide.Here,we report results of a descriptive,exploratory analysis of all cases diagnosed as of February 11,2020.Methods:All COVID-19 cases reported through February 11,2020 were extracted from China’s Infectious Disease Information System.Analyses included the following:(1)summary of patient characteristics;(2)examination of age distributions and sex ratios;(3)calculation of case fatality and mortality rates;(4)geo-temporal analysis of viral spread;(5)epidemiological curve construction;and (6)subgroup analysis.Results:A total of 72,314 patient records—44,672(61.8%)confirmed cases,16,186(22.4%)suspected cases,10,567(14.6%)clinically diagnosed cases(Hubei Province only),and 889 asymptomatic cases(1.2%)-contributed data for the analysis.Among confirmed cases,most were aged 30–79 years(86.6%),diagnosed in Hubei(74.7%),and considered mild(80.9%).A total of 1,023 deaths occurred among confirmed cases for an overall case fatality rate of 2.3%.The COVID-19 spread outward from Hubei Province sometime after December 2019,and by February 11,2020,1,386 counties across all 31 provinces were affected.The epidemic curve of onset of symptoms peaked around January 23–26,then began to decline leading up to February 11.A total of 1,716 health workers have become infected and 5 have died(0.3%).Conclusions:COVID-19 epidemic has spread very quickly taking only 30 days to expand from Hubei to the rest of China's Mainland.With many people returning from a long holiday,China needs to prepare for the possible rebound of the epidemic.
