目的:观察高海拔地区先天性心脏病患儿到低海拔地区行先天性心脏病矫治手术的临床指标和短期预后,以探讨其围手术期的安全性。方法:回顾性分析2016年1至12月在中南大学湘雅医院择期行先天性心脏病矫治手术的来自西藏自治区(X组)和湖南...目的:观察高海拔地区先天性心脏病患儿到低海拔地区行先天性心脏病矫治手术的临床指标和短期预后,以探讨其围手术期的安全性。方法:回顾性分析2016年1至12月在中南大学湘雅医院择期行先天性心脏病矫治手术的来自西藏自治区(X组)和湖南省(H组)的患儿各7例。比较两组患儿心脏超声心动图检查指标、围手术期血流动力学、术后恢复与并发症和围手术期氨基末端脑钠肽前体(N terminal pro B type natriuretic peptide,NT-proBNP)水平。结果:心脏超声心动图显示两组患儿心脏结构和心功能无明显差异,X组患儿肺高压的发生率明显高于H组(P<0.05)。围手术期血流动力学比较两组之间差异无统计学意义(P>0.05),术后ICU停留时间X组患儿更长(P<0.05)。血清NT-proBNP水平X组患儿明显高于H组(P<0.05)。结论:高海拔地区的先天性心脏病患儿到低海拔地区行先天性心脏病矫治手术有助于提高围手术期安全性,麻醉手术中血流动力学平稳,但术后心功能不全风险仍高于低海拔地区患儿,术后恢复时间延长。展开更多
Resveratrol, as a natural polyphenolic compound, has a wide range of beneficial effects, which includes anti-tumor, cardiovascular protection, anti-oxidant and estrogen-like effects, and so on. Its various physiologic...Resveratrol, as a natural polyphenolic compound, has a wide range of beneficial effects, which includes anti-tumor, cardiovascular protection, anti-oxidant and estrogen-like effects, and so on. Its various physiological properties are closely related to the therapeutic principle for prevention and treatment of high altitude hypoxia injury. Resveratrol may play an important role in relieving or curing high altitude diseases, especially high altitude polycythemia(HAPC). However, the literature about study and application of resveratrol in plateau medicine field is rarely reported up to now. In this review, we summarized the physiological effects of resveratrol, discussed the possible main principle of resveratrol for HAPC therapy, and looked forward to resveratrol's perspective or potential application in high altitude medicine.展开更多
高原生理学是高原医学的核心基础学科,是高原医学专业本科生的专业必修课程。高原生理学目前主要采取传统讲授式教学,教学方式相对单一,在一定程度上影响了学生的学习效果。慕课(massive open online course,MOOC)是新近涌现出的一种在...高原生理学是高原医学的核心基础学科,是高原医学专业本科生的专业必修课程。高原生理学目前主要采取传统讲授式教学,教学方式相对单一,在一定程度上影响了学生的学习效果。慕课(massive open online course,MOOC)是新近涌现出的一种在线开发课程,其教育理念先进。在当前军队改革的大背景条件下,将MOOC有效结合到高原生理学课程教学中,使教学模式得到转变的同时提高教学质量和促进教学相长。这样不仅能全面提高学生的学习效果,更有助于提高高原军事医学学生的岗位任职能力,有效服务高原部队。展开更多
文摘目的:观察高海拔地区先天性心脏病患儿到低海拔地区行先天性心脏病矫治手术的临床指标和短期预后,以探讨其围手术期的安全性。方法:回顾性分析2016年1至12月在中南大学湘雅医院择期行先天性心脏病矫治手术的来自西藏自治区(X组)和湖南省(H组)的患儿各7例。比较两组患儿心脏超声心动图检查指标、围手术期血流动力学、术后恢复与并发症和围手术期氨基末端脑钠肽前体(N terminal pro B type natriuretic peptide,NT-proBNP)水平。结果:心脏超声心动图显示两组患儿心脏结构和心功能无明显差异,X组患儿肺高压的发生率明显高于H组(P<0.05)。围手术期血流动力学比较两组之间差异无统计学意义(P>0.05),术后ICU停留时间X组患儿更长(P<0.05)。血清NT-proBNP水平X组患儿明显高于H组(P<0.05)。结论:高海拔地区的先天性心脏病患儿到低海拔地区行先天性心脏病矫治手术有助于提高围手术期安全性,麻醉手术中血流动力学平稳,但术后心功能不全风险仍高于低海拔地区患儿,术后恢复时间延长。
基金supported by grants from the National Natural Science Foundation of China(81471812)National New Drug Research and Development of Key Project(2011ZXJ09202-0212011ZXJ09105-05B)
文摘Resveratrol, as a natural polyphenolic compound, has a wide range of beneficial effects, which includes anti-tumor, cardiovascular protection, anti-oxidant and estrogen-like effects, and so on. Its various physiological properties are closely related to the therapeutic principle for prevention and treatment of high altitude hypoxia injury. Resveratrol may play an important role in relieving or curing high altitude diseases, especially high altitude polycythemia(HAPC). However, the literature about study and application of resveratrol in plateau medicine field is rarely reported up to now. In this review, we summarized the physiological effects of resveratrol, discussed the possible main principle of resveratrol for HAPC therapy, and looked forward to resveratrol's perspective or potential application in high altitude medicine.
文摘高原生理学是高原医学的核心基础学科,是高原医学专业本科生的专业必修课程。高原生理学目前主要采取传统讲授式教学,教学方式相对单一,在一定程度上影响了学生的学习效果。慕课(massive open online course,MOOC)是新近涌现出的一种在线开发课程,其教育理念先进。在当前军队改革的大背景条件下,将MOOC有效结合到高原生理学课程教学中,使教学模式得到转变的同时提高教学质量和促进教学相长。这样不仅能全面提高学生的学习效果,更有助于提高高原军事医学学生的岗位任职能力,有效服务高原部队。
