Seven residual heterozygous lines （RHLs） displaying different genotypic compositions in the genomic region covering probable locations of C （Chromogen for anthocyanin） gene on the short arm of rice chromosome 6 we...Seven residual heterozygous lines （RHLs） displaying different genotypic compositions in the genomic region covering probable locations of C （Chromogen for anthocyanin） gene on the short arm of rice chromosome 6 were selected from the progenies of the indica cross Zhenshan 97B/Milyang 46. Seeds were harvested from each of the seven plants, and the resultant F2：3 populations were used for fine mapping of C gene. It was shown in the populations that the apiculus coloration matched to basal leaf sheath coloration in each plant. By relating the coloration performances of the populations with the genotypic compositions of the RHLs, the C locus was located between rice SSR markers RM314 and RM253. By using a total of 1279 F2：3 individuals from two populations showing coloration segregation, the C locus was then located between RM111 and RM253, with genetic distances of 0.7 cM to RM111 and 0.4 cM to RM253. Twenty-two recombinants found in the two populations were assayed with seven more markers located between RM111 and RM253, including six SSR markers and one marker for the C gene candidate, OsCl. The C locus was delimited to a 59.3-kb region in which OsC1 was located.展开更多
不宁腿综合征(restless legs syndrome,RLS)是一种常见的神经系统疾病,特点是不舒服的腿部冲动,在运动或起身行走时缓解,并在夜间症状加重。RLS的发病机制仍不清楚,但随着病理生理学研究的进展,发现可能涉及中枢神经系统的多巴胺功能障...不宁腿综合征(restless legs syndrome,RLS)是一种常见的神经系统疾病,特点是不舒服的腿部冲动,在运动或起身行走时缓解,并在夜间症状加重。RLS的发病机制仍不清楚,但随着病理生理学研究的进展,发现可能涉及中枢神经系统的多巴胺功能障碍,以及其他未确定的促进机制,特别是缺铁和慢性肾功能障碍。有家族史的遗传易感性很常见。RLS增强的特点是症状的严重性更强,症状发生的时间更早,而且常常是症状从腿部扩散至手臂或身体其他区域。一些RLS患者通过非药物措施,如按摩和温水浴,可以充分控制症状。一线治疗方案包括对体内铁储存减少的人进行铁补充治疗,或使用加巴喷丁、普瑞巴林,以及多巴胺激动剂,如普拉克索、罗匹尼罗和罗替戈汀。二线疗法包括曲马多、羟考酮和美沙酮等阿片类药物。RLS严重影响患者的生活质量,且仍是一个非常需要创新的治疗领域,需要有更多新的、有生物依据的治疗方法。展开更多
基金This work was supported by the Chinese 863 Program(Grant No.2006AA10Z1E8)the Super Rice Program of the Chinese Ministry of Agriculture(Grant No.200606)the Natural Science Foundation of Zhejiang Province(Grant No.Y304446).
文摘Seven residual heterozygous lines （RHLs） displaying different genotypic compositions in the genomic region covering probable locations of C （Chromogen for anthocyanin） gene on the short arm of rice chromosome 6 were selected from the progenies of the indica cross Zhenshan 97B/Milyang 46. Seeds were harvested from each of the seven plants, and the resultant F2：3 populations were used for fine mapping of C gene. It was shown in the populations that the apiculus coloration matched to basal leaf sheath coloration in each plant. By relating the coloration performances of the populations with the genotypic compositions of the RHLs, the C locus was located between rice SSR markers RM314 and RM253. By using a total of 1279 F2：3 individuals from two populations showing coloration segregation, the C locus was then located between RM111 and RM253, with genetic distances of 0.7 cM to RM111 and 0.4 cM to RM253. Twenty-two recombinants found in the two populations were assayed with seven more markers located between RM111 and RM253, including six SSR markers and one marker for the C gene candidate, OsCl. The C locus was delimited to a 59.3-kb region in which OsC1 was located.
文摘不宁腿综合征(restless legs syndrome,RLS)是一种常见的神经系统疾病,特点是不舒服的腿部冲动,在运动或起身行走时缓解,并在夜间症状加重。RLS的发病机制仍不清楚,但随着病理生理学研究的进展,发现可能涉及中枢神经系统的多巴胺功能障碍,以及其他未确定的促进机制,特别是缺铁和慢性肾功能障碍。有家族史的遗传易感性很常见。RLS增强的特点是症状的严重性更强,症状发生的时间更早,而且常常是症状从腿部扩散至手臂或身体其他区域。一些RLS患者通过非药物措施,如按摩和温水浴,可以充分控制症状。一线治疗方案包括对体内铁储存减少的人进行铁补充治疗,或使用加巴喷丁、普瑞巴林,以及多巴胺激动剂,如普拉克索、罗匹尼罗和罗替戈汀。二线疗法包括曲马多、羟考酮和美沙酮等阿片类药物。RLS严重影响患者的生活质量,且仍是一个非常需要创新的治疗领域,需要有更多新的、有生物依据的治疗方法。
