Background Found in inflammatory zone 1 （FIZZ1） protein increased in pulmonary epithelial cells and in limited amounts of other lung cells.FIZZ1 increased in murine model of smoke induced chronic obstructive pulmona...Background Found in inflammatory zone 1 （FIZZ1） protein increased in pulmonary epithelial cells and in limited amounts of other lung cells.FIZZ1 increased in murine model of smoke induced chronic obstructive pulmonary disease.However,the direct role of FIZZ1 produced by pulmonary epithelium stimulated with cigarette smoke extraction has not been determined.We examined the expression and function of FIZZ1 in rat lung epithelial L2 cells.Methods The rat lung epithelial L2 cells （CCL 149） were exposed to cigarette smoke extraction,expression of FIZZ1 mRNA was investigated by RT-PCR.Levels of FIZZ1 protein were detected by Western blotting and laser confocal microscope.CCL 149 cells were treated with different concentrations and for different time of recombinant protein FIZZ1.After treatment,the expression levels of interleukin 8 （IL-8） were detected by enzyme-linked immunosorbent assay （ELISA）.Results When CCL 149 cells were exposed to cigarette smoke extraction,FIZZ1 mRNA and protein levels expressed significantly higher than control group.Recombinant protein FIZZ1 promoted the expression of IL-8 in a dose and time dependent manner in a certain range.Conclusions Cigarette smoke extraction activates FIZZ1 at mRNA and protein levels in CCL 149 cells.Recombinant protein FIZZ1 induces the expression of IL-8 and may thus participate in the process of chronic obstructive pulmonary disease airway inflammation and airflow obstruction.Generally,immune cells such as macrophages,neutrophils and lymphocytes are unavoidably involved in airway inflammatory and immune responses to cigarette smoke,but it is still unclear whether their involvement in the pathogenesis of chronic obstructive pulmonary disease is based on the specific expression in lung epithelial cells of FIZZ1.展开更多
CO<sub>2</sub>-RICH fluid inclusions have been found in 6 anhydrous peridotite xenolith minerals in Ceno-zoic basalts of 5 areas in East China.Electron probe backscattering electron image reveals thatsever...CO<sub>2</sub>-RICH fluid inclusions have been found in 6 anhydrous peridotite xenolith minerals in Ceno-zoic basalts of 5 areas in East China.Electron probe backscattering electron image reveals thatseveral inclusions appear in all the rock sections,completely filled with glass or with cavities attheir center part（CO<sub>2</sub> has escaped）.Some inclusions show devitrification and daughter miner-als appear.We have carried out the analysis on the non-devitrification glass in the inclusions.展开更多
Polysurfacic tori or kideas are three-dimensional objects formed by rotating a regular polygon around a central axis. These toric shapes are referred to as “polysurfacic” because their characteristics, such as the n...Polysurfacic tori or kideas are three-dimensional objects formed by rotating a regular polygon around a central axis. These toric shapes are referred to as “polysurfacic” because their characteristics, such as the number of sides or surfaces separated by edges, can vary in a non-trivial manner depending on the degree of twisting during the revolution. We use the term “Kideas” to specifically denote these polysurfacic tori, and we represent the number of sides (referred to as “facets”) of the original polygon followed by a point, while the number of facets from which the torus is twisted during its revolution is indicated. We then explore the use of concave regular polygons to generate Kideas. We finally give acceleration for the algorithm for calculating the set of prime numbers.展开更多
In view of the problems such as the lower automation level and the insufficient precision of the traditional fiber optic gyroscope （FOG） static north-finder, this paper focuses on the in-depth analysis of the FOG dy...In view of the problems such as the lower automation level and the insufficient precision of the traditional fiber optic gyroscope （FOG） static north-finder, this paper focuses on the in-depth analysis of the FOG dynamic north-finder principle and algorithm. The simulation model of the FOG dynamic north found algorithm with the least square method by points is established using Simulink toolbox, and then the platform rotation speed and sampling frequency, which affect FOG dynamic north found precision obviously, are simulated and calculated, and the optimization analysis is carried out as a key consideration. The simulation results show that, when the platform rotation speed is between 4.5°/s and 8.5°/s and the sampling frequency is at about 50Hz in the case of using the parameters of this paper, the FOG dynamic north finding system can reach the higher precision. And the conclusions can provide the reference and validation for the engineering and practical of FOG dynamic north-finder.展开更多
Objective A set of REE-rich clay rocks is formed at the top of the Emeishan basalt in the eastern Yunnan-Western Guizhou area,accompanied by Nb,Zr,Ga.It is a new type of REE deposit and has great resource potential.Th...Objective A set of REE-rich clay rocks is formed at the top of the Emeishan basalt in the eastern Yunnan-Western Guizhou area,accompanied by Nb,Zr,Ga.It is a new type of REE deposit and has great resource potential.This paper introduces its metallogenic conditions and element occurrence states,discusses the genetic mechanism.展开更多
基金The study was supported by a grant from Natural Science Foundation of Guangdong Province,China （No.10151063201000035）.
文摘Background Found in inflammatory zone 1 （FIZZ1） protein increased in pulmonary epithelial cells and in limited amounts of other lung cells.FIZZ1 increased in murine model of smoke induced chronic obstructive pulmonary disease.However,the direct role of FIZZ1 produced by pulmonary epithelium stimulated with cigarette smoke extraction has not been determined.We examined the expression and function of FIZZ1 in rat lung epithelial L2 cells.Methods The rat lung epithelial L2 cells （CCL 149） were exposed to cigarette smoke extraction,expression of FIZZ1 mRNA was investigated by RT-PCR.Levels of FIZZ1 protein were detected by Western blotting and laser confocal microscope.CCL 149 cells were treated with different concentrations and for different time of recombinant protein FIZZ1.After treatment,the expression levels of interleukin 8 （IL-8） were detected by enzyme-linked immunosorbent assay （ELISA）.Results When CCL 149 cells were exposed to cigarette smoke extraction,FIZZ1 mRNA and protein levels expressed significantly higher than control group.Recombinant protein FIZZ1 promoted the expression of IL-8 in a dose and time dependent manner in a certain range.Conclusions Cigarette smoke extraction activates FIZZ1 at mRNA and protein levels in CCL 149 cells.Recombinant protein FIZZ1 induces the expression of IL-8 and may thus participate in the process of chronic obstructive pulmonary disease airway inflammation and airflow obstruction.Generally,immune cells such as macrophages,neutrophils and lymphocytes are unavoidably involved in airway inflammatory and immune responses to cigarette smoke,but it is still unclear whether their involvement in the pathogenesis of chronic obstructive pulmonary disease is based on the specific expression in lung epithelial cells of FIZZ1.
文摘CO<sub>2</sub>-RICH fluid inclusions have been found in 6 anhydrous peridotite xenolith minerals in Ceno-zoic basalts of 5 areas in East China.Electron probe backscattering electron image reveals thatseveral inclusions appear in all the rock sections,completely filled with glass or with cavities attheir center part（CO<sub>2</sub> has escaped）.Some inclusions show devitrification and daughter miner-als appear.We have carried out the analysis on the non-devitrification glass in the inclusions.
文摘Polysurfacic tori or kideas are three-dimensional objects formed by rotating a regular polygon around a central axis. These toric shapes are referred to as “polysurfacic” because their characteristics, such as the number of sides or surfaces separated by edges, can vary in a non-trivial manner depending on the degree of twisting during the revolution. We use the term “Kideas” to specifically denote these polysurfacic tori, and we represent the number of sides (referred to as “facets”) of the original polygon followed by a point, while the number of facets from which the torus is twisted during its revolution is indicated. We then explore the use of concave regular polygons to generate Kideas. We finally give acceleration for the algorithm for calculating the set of prime numbers.
文摘In view of the problems such as the lower automation level and the insufficient precision of the traditional fiber optic gyroscope （FOG） static north-finder, this paper focuses on the in-depth analysis of the FOG dynamic north-finder principle and algorithm. The simulation model of the FOG dynamic north found algorithm with the least square method by points is established using Simulink toolbox, and then the platform rotation speed and sampling frequency, which affect FOG dynamic north found precision obviously, are simulated and calculated, and the optimization analysis is carried out as a key consideration. The simulation results show that, when the platform rotation speed is between 4.5°/s and 8.5°/s and the sampling frequency is at about 50Hz in the case of using the parameters of this paper, the FOG dynamic north finding system can reach the higher precision. And the conclusions can provide the reference and validation for the engineering and practical of FOG dynamic north-finder.
基金supported by the National Natural Science Foundation of China(grant No.41602120)CGS Geological survey project(grant No.DD20189507).
文摘Objective A set of REE-rich clay rocks is formed at the top of the Emeishan basalt in the eastern Yunnan-Western Guizhou area,accompanied by Nb,Zr,Ga.It is a new type of REE deposit and has great resource potential.This paper introduces its metallogenic conditions and element occurrence states,discusses the genetic mechanism.
