Background: Bilirubin is the metabolic end-product of heme degradation by heme oxy-genase (HO), which has recently been shown to act as an antioxidant which can protect against atherosclerosis. This study explored the...Background: Bilirubin is the metabolic end-product of heme degradation by heme oxy-genase (HO), which has recently been shown to act as an antioxidant which can protect against atherosclerosis. This study explored the relationship between serum bilirubin levels and different degrees of atherosclerotic stenosis in intracranial or extracranial arteries. Methods: The study included 189 patients undergoing digital subtraction angiography (DSA) diagnosed as being normal or having been confirmed as atherosc lerotic stenosis in the intracranial or extracranial arteries. The patients were allocated to normal, mild (Results: Indirect bilirubin (Ibil) concentrations increased in parallel with the increasing severity of atherosclerotic stenosis in the intracranial or extracranial arteries, but decreased in patients with occluded cranial vessels. Multivariate analysis showed that Ibil levels were significantly higher in patients with severe stenosis group than in those with mild stenosis (OR, 1.464;95% CI, 1.050 - 2.042;P = 0.024). However, Ibil levels were significantly lower in patients with occlusion than in those with severe stenosis (OR, 0.790;95% CI, 0.684 - 0.913;P = 0.001). Conclusions: Ibil appears to have a protective effect against the development of atherosclerotic stenosis in intracranial or extracranial arteries. The biosynthesis of Ibil increases with stenosis progresses but decreases once occlusion occurs.展开更多
目的研究取栓支架引导中间导管通过技术(stent/solitaire leading intermediate catheter passing,SLIP)在治疗颅内外动脉急性串联闭塞合并近端不稳定血栓病变的临床运用。方法选取2020年10—11月无棣县人民医院1例颅内外动脉急性串联...目的研究取栓支架引导中间导管通过技术(stent/solitaire leading intermediate catheter passing,SLIP)在治疗颅内外动脉急性串联闭塞合并近端不稳定血栓病变的临床运用。方法选取2020年10—11月无棣县人民医院1例颅内外动脉急性串联闭塞患者的临床资料、手术过程、治疗经过等进行回顾性分析,总结该技术的操作要点及技术优势。结果运用该技术快速成功实现闭塞动脉再通,mTICI分级3级;患者预后良好,NIHSS评分0分。结论SLIP/滑行技术在处理颅内外动脉急性串联闭塞合并近端不稳定血栓病变时,操作更为简洁快速、血栓逃逸概率更低、手术成功率更高。展开更多
文摘Background: Bilirubin is the metabolic end-product of heme degradation by heme oxy-genase (HO), which has recently been shown to act as an antioxidant which can protect against atherosclerosis. This study explored the relationship between serum bilirubin levels and different degrees of atherosclerotic stenosis in intracranial or extracranial arteries. Methods: The study included 189 patients undergoing digital subtraction angiography (DSA) diagnosed as being normal or having been confirmed as atherosc lerotic stenosis in the intracranial or extracranial arteries. The patients were allocated to normal, mild (Results: Indirect bilirubin (Ibil) concentrations increased in parallel with the increasing severity of atherosclerotic stenosis in the intracranial or extracranial arteries, but decreased in patients with occluded cranial vessels. Multivariate analysis showed that Ibil levels were significantly higher in patients with severe stenosis group than in those with mild stenosis (OR, 1.464;95% CI, 1.050 - 2.042;P = 0.024). However, Ibil levels were significantly lower in patients with occlusion than in those with severe stenosis (OR, 0.790;95% CI, 0.684 - 0.913;P = 0.001). Conclusions: Ibil appears to have a protective effect against the development of atherosclerotic stenosis in intracranial or extracranial arteries. The biosynthesis of Ibil increases with stenosis progresses but decreases once occlusion occurs.
文摘目的研究取栓支架引导中间导管通过技术(stent/solitaire leading intermediate catheter passing,SLIP)在治疗颅内外动脉急性串联闭塞合并近端不稳定血栓病变的临床运用。方法选取2020年10—11月无棣县人民医院1例颅内外动脉急性串联闭塞患者的临床资料、手术过程、治疗经过等进行回顾性分析,总结该技术的操作要点及技术优势。结果运用该技术快速成功实现闭塞动脉再通,mTICI分级3级;患者预后良好,NIHSS评分0分。结论SLIP/滑行技术在处理颅内外动脉急性串联闭塞合并近端不稳定血栓病变时,操作更为简洁快速、血栓逃逸概率更低、手术成功率更高。
