Rheumatoid arthritis(RA)is a common autoimmune condition with an elusive etiology.Conventional and biological disease-modifying drugs sometimes fail or produce only partial responses.Traditional Chinese medicine(TCM)h...Rheumatoid arthritis(RA)is a common autoimmune condition with an elusive etiology.Conventional and biological disease-modifying drugs sometimes fail or produce only partial responses.Traditional Chinese medicine(TCM)has long been used in China as a treatment for RA and is achieving everincreasing acceptance worldwide.TCM treatments are traditionally guided by the theory of treatment based on TCM syndrome differentiation;however,they remain a matter of empirical practice relying on TCM theories and doctors’own experience,which places severe restrictions on worldwide TCM application.Nevertheless,TCM is a treasure trove for drug discovery,particularly as a treatment for complicated human conditions.The discoveries of artemisinin as a treatment for malaria and of TCM–arsenic trioxide(As2O3)combination therapy as a treatment for acute promyelocytic leukemia(APL)are excellent examples of the great value of TCM.Regarding RA treatments,many Chinese medicinal herbs and their formulas,extracts,ingredients,and even single compounds have been used in clinical applications.Several Chinese proprietary medicines(CPMs)derived from TCM formulas or herbal bioactive components,such as the controlled-release ZhengQingFengTongNing(ZQFTN)Tablets,Tripterygium Glycoside Tablets,and Total Glucosides of Peony(TGP)Capsules,have been included in the National Health Insurance Directory of China,and show comparable therapeutic efficacies to those of western chemical drugs with fewer side effects.As TCM research has advanced,particularly in the use of multidisciplinary technologies,the scientific foundations and characteristics of the use of TCM to treat RA have been revealed,and the quality of TCM treatments have been increasingly enhanced.However,TCM generally lacks sufficient clinical and laboratory data to be consistent with international standards for quality,safety,and efficacy in order to support its application worldwide.Therefore,intensive basic and clinical studies on TCM are required.In particular,investigations that use cutting展开更多
目的：系统评价中医辨证论治多发性硬化（MS）的临床疗效。方法：全面检索中国期刊全文数据库、维普中文科技期刊全文数据库、中国生物医学文献服务系统、万方医药期刊数据库、Pub Med、Cochrane图书馆等数据库。中文检索词以＂多发性...目的：系统评价中医辨证论治多发性硬化（MS）的临床疗效。方法：全面检索中国期刊全文数据库、维普中文科技期刊全文数据库、中国生物医学文献服务系统、万方医药期刊数据库、Pub Med、Cochrane图书馆等数据库。中文检索词以＂多发性硬化＂和＂中药或针灸或中西医结合＂为并列检索词,英文检索词为＂multiple sclerosis or MS＂AND＂traditional Chinese medicine or herb or herbal or acupuncture or combined traditional Chinese and western medicine＂检索中医辨证治疗MS的随机对照临床试验文献,时间区间设定为2000年1月1日—2016年10月30日。按照Cochrane系统评价手册推荐的简单评价法,评价纳入研究的方法学质量。软件版本为Review Manger 5.3,结局效应指标分别为EDSS评分（EDSS）、有效率、复发次数、临床症状评分、神经功能体征评分。结果：最终纳入16个随机对照临床试验,共906例研究对象。所纳入的研究中有13项研究报道了EDSS评分,纳入统计的为11项,试验组与对照组比较,MD及95%CI为-0.96（-1.50,-0.41）,P〈0.05,有统计学差异;有12项研究观察了有效率,11项研究可提取有效数据,OR值为4.93,95%CI为（3.05,7.96）,P〈0.001,统计学有显著差异;有3项研究对患者进行了复发次数评价,MD及95%CI为-0.43（-0.67,-0.19）,P〈0.05,有统计学差异;有8项研究观察了临床症状评分,7项可提取有效数据,MD及95%CI为-1.09（-3.41,1.23）,P〉0.05,统计学无差异;有4项研究观察了神经功能体征评分,试验组与对照组比较,MD及95%CI为-1.86（-4.70,0.97）,P〉0.05,统计学无差异。结论：中医辨证论治结合西药治疗MS相对于单纯西药治疗,提高了其有效率,减少MS的复发次数,改善神经功能缺损。展开更多
文摘Rheumatoid arthritis(RA)is a common autoimmune condition with an elusive etiology.Conventional and biological disease-modifying drugs sometimes fail or produce only partial responses.Traditional Chinese medicine(TCM)has long been used in China as a treatment for RA and is achieving everincreasing acceptance worldwide.TCM treatments are traditionally guided by the theory of treatment based on TCM syndrome differentiation;however,they remain a matter of empirical practice relying on TCM theories and doctors’own experience,which places severe restrictions on worldwide TCM application.Nevertheless,TCM is a treasure trove for drug discovery,particularly as a treatment for complicated human conditions.The discoveries of artemisinin as a treatment for malaria and of TCM–arsenic trioxide(As2O3)combination therapy as a treatment for acute promyelocytic leukemia(APL)are excellent examples of the great value of TCM.Regarding RA treatments,many Chinese medicinal herbs and their formulas,extracts,ingredients,and even single compounds have been used in clinical applications.Several Chinese proprietary medicines(CPMs)derived from TCM formulas or herbal bioactive components,such as the controlled-release ZhengQingFengTongNing(ZQFTN)Tablets,Tripterygium Glycoside Tablets,and Total Glucosides of Peony(TGP)Capsules,have been included in the National Health Insurance Directory of China,and show comparable therapeutic efficacies to those of western chemical drugs with fewer side effects.As TCM research has advanced,particularly in the use of multidisciplinary technologies,the scientific foundations and characteristics of the use of TCM to treat RA have been revealed,and the quality of TCM treatments have been increasingly enhanced.However,TCM generally lacks sufficient clinical and laboratory data to be consistent with international standards for quality,safety,and efficacy in order to support its application worldwide.Therefore,intensive basic and clinical studies on TCM are required.In particular,investigations that use cutting
文摘目的：系统评价中医辨证论治多发性硬化（MS）的临床疗效。方法：全面检索中国期刊全文数据库、维普中文科技期刊全文数据库、中国生物医学文献服务系统、万方医药期刊数据库、Pub Med、Cochrane图书馆等数据库。中文检索词以＂多发性硬化＂和＂中药或针灸或中西医结合＂为并列检索词,英文检索词为＂multiple sclerosis or MS＂AND＂traditional Chinese medicine or herb or herbal or acupuncture or combined traditional Chinese and western medicine＂检索中医辨证治疗MS的随机对照临床试验文献,时间区间设定为2000年1月1日—2016年10月30日。按照Cochrane系统评价手册推荐的简单评价法,评价纳入研究的方法学质量。软件版本为Review Manger 5.3,结局效应指标分别为EDSS评分（EDSS）、有效率、复发次数、临床症状评分、神经功能体征评分。结果：最终纳入16个随机对照临床试验,共906例研究对象。所纳入的研究中有13项研究报道了EDSS评分,纳入统计的为11项,试验组与对照组比较,MD及95%CI为-0.96（-1.50,-0.41）,P〈0.05,有统计学差异;有12项研究观察了有效率,11项研究可提取有效数据,OR值为4.93,95%CI为（3.05,7.96）,P〈0.001,统计学有显著差异;有3项研究对患者进行了复发次数评价,MD及95%CI为-0.43（-0.67,-0.19）,P〈0.05,有统计学差异;有8项研究观察了临床症状评分,7项可提取有效数据,MD及95%CI为-1.09（-3.41,1.23）,P〉0.05,统计学无差异;有4项研究观察了神经功能体征评分,试验组与对照组比较,MD及95%CI为-1.86（-4.70,0.97）,P〉0.05,统计学无差异。结论：中医辨证论治结合西药治疗MS相对于单纯西药治疗,提高了其有效率,减少MS的复发次数,改善神经功能缺损。
