With acquisition and accumulation of new data of structural geological investigations and high-resolution isotopic dating data, we have greatly improved our understanding of the tectonic events occurring in eastern Ch...With acquisition and accumulation of new data of structural geological investigations and high-resolution isotopic dating data, we have greatly improved our understanding of the tectonic events occurring in eastern China during the period from the Late Jurassic to Early Cretaceous and may give a new interpretation of the nature, timing and geodynamic settings of the “Yanshan Movement”. During the Mid-Late Jurassic （165±5 Ma）, great readjustment of plate amalgamation kinematics took place in East Asia and the tectonic regime underwent great transformation, thus initiating a new tectonic regime in which the North China Block was the center and different plates converged toward it from the north, east and southwest and forming the “East Asia convergent” tectonic system characterized by intracontinental subduction and orogeny. As a consequence, the crustal lithosphere of the East Asian continent thickened considerably during the Late Jurassic, followed immediately by Early Cretaceous substantial lithospheric thinning and craton destruction featured by drastic lithospheric extension and widespread volcano-magmatic activities, resulting in a major biotic turnover from the Yanliao biota to Jehol Biota. Such a tremendous tectonic event that took place in the continent of China and East Asia is the basic connotation of the “Yanshan Movement”. In the paper, according to the deformation patterns, geodynamic settings and deep processes, the “Yanshan Movement” is redefined as the Late Jurassic East Asian multi-directional plate convergent tectonic regime and its associated extensive intracontinental orogeny and great tectonic change that started at -165±5 Ma. The substantial lithospheric attenuation in East China is considered the post-effect of the Yanshanian intracontinental orogeny and deformation.展开更多
East Asians are the most populous race in the world and their health status is an important global issue.Compared with Caucasian populations, East Asian patients have a different benefit/risk ratio when using antithro...East Asians are the most populous race in the world and their health status is an important global issue.Compared with Caucasian populations, East Asian patients have a different benefit/risk ratio when using antithrombotic treatment. Despite this observation, treatment strategies in East Asian patients are mostly based on the American and European guidelines. Despite a lower platelet inhibitory response to clopidogrel, East Asian patients show a similar or even a lower rate of ischemic event occurrence and higher bleeding risk compared with Caucasian patients. For potent P2Y_(12) inhibitors(ticagrelor and prasugrel),East Asian patients have shown less favorable net clinical benefits compared with Caucasian patients,which may be related to differences in pharmacokinetic/pharmacodynamic profiles and therapeutic zone of antiplatelet effect. This updated consensus mainly focuses on state-of-the-art and current controversies in the East Asian population. In addition, when East Asian patients are administered potent P2Y_(12) receptor inhibitors, the strategies and ongoing trials to overcome the related hurdles are discussed.展开更多
文摘With acquisition and accumulation of new data of structural geological investigations and high-resolution isotopic dating data, we have greatly improved our understanding of the tectonic events occurring in eastern China during the period from the Late Jurassic to Early Cretaceous and may give a new interpretation of the nature, timing and geodynamic settings of the “Yanshan Movement”. During the Mid-Late Jurassic （165±5 Ma）, great readjustment of plate amalgamation kinematics took place in East Asia and the tectonic regime underwent great transformation, thus initiating a new tectonic regime in which the North China Block was the center and different plates converged toward it from the north, east and southwest and forming the “East Asia convergent” tectonic system characterized by intracontinental subduction and orogeny. As a consequence, the crustal lithosphere of the East Asian continent thickened considerably during the Late Jurassic, followed immediately by Early Cretaceous substantial lithospheric thinning and craton destruction featured by drastic lithospheric extension and widespread volcano-magmatic activities, resulting in a major biotic turnover from the Yanliao biota to Jehol Biota. Such a tremendous tectonic event that took place in the continent of China and East Asia is the basic connotation of the “Yanshan Movement”. In the paper, according to the deformation patterns, geodynamic settings and deep processes, the “Yanshan Movement” is redefined as the Late Jurassic East Asian multi-directional plate convergent tectonic regime and its associated extensive intracontinental orogeny and great tectonic change that started at -165±5 Ma. The substantial lithospheric attenuation in East China is considered the post-effect of the Yanshanian intracontinental orogeny and deformation.
基金partly supported by the National Research Foundation (NRF) Republic of Korea (NRF-2015R1A5A2008833)
文摘East Asians are the most populous race in the world and their health status is an important global issue.Compared with Caucasian populations, East Asian patients have a different benefit/risk ratio when using antithrombotic treatment. Despite this observation, treatment strategies in East Asian patients are mostly based on the American and European guidelines. Despite a lower platelet inhibitory response to clopidogrel, East Asian patients show a similar or even a lower rate of ischemic event occurrence and higher bleeding risk compared with Caucasian patients. For potent P2Y_(12) inhibitors(ticagrelor and prasugrel),East Asian patients have shown less favorable net clinical benefits compared with Caucasian patients,which may be related to differences in pharmacokinetic/pharmacodynamic profiles and therapeutic zone of antiplatelet effect. This updated consensus mainly focuses on state-of-the-art and current controversies in the East Asian population. In addition, when East Asian patients are administered potent P2Y_(12) receptor inhibitors, the strategies and ongoing trials to overcome the related hurdles are discussed.
