An unusual substitution reaction of an aromatic sulfonic group based on 3-carbonyl-4-phenolsulfonic acid was discovered in a diazo-coupling process. The reaction occurred under mild reaction conditions （pH 8.0-9.0, 0...An unusual substitution reaction of an aromatic sulfonic group based on 3-carbonyl-4-phenolsulfonic acid was discovered in a diazo-coupling process. The reaction occurred under mild reaction conditions （pH 8.0-9.0, 0-5 ℃, solvent： water） within a short reaction time （1 h）. A plausible substitution reaction mechanism by phenol-ketone resonance was proposed.展开更多
在室温下,以对氯邻硝基苯胺邻叔丁基对甲基苯酚和亚硝酸钠为原料通过固相重氮偶合反应一步合成了2-硝基-4-氯-2′-羟基-3′-特丁基-5′-甲基偶氮苯。反应时间15 m in,产率达93%。以HPLC分析,其纯度>99%,并用IR和UV光谱等对其结构进...在室温下,以对氯邻硝基苯胺邻叔丁基对甲基苯酚和亚硝酸钠为原料通过固相重氮偶合反应一步合成了2-硝基-4-氯-2′-羟基-3′-特丁基-5′-甲基偶氮苯。反应时间15 m in,产率达93%。以HPLC分析,其纯度>99%,并用IR和UV光谱等对其结构进行了表征和确认。展开更多
基金supported by the National Natural Science Foundation for Young Scholar of China(No.21276042)the National Science and Technology Pillar Program(No. 2013BAF08B06)Jiaogai Foundation of DUT(No.JGXM201224)
文摘An unusual substitution reaction of an aromatic sulfonic group based on 3-carbonyl-4-phenolsulfonic acid was discovered in a diazo-coupling process. The reaction occurred under mild reaction conditions （pH 8.0-9.0, 0-5 ℃, solvent： water） within a short reaction time （1 h）. A plausible substitution reaction mechanism by phenol-ketone resonance was proposed.
