The densities of the selected quaternary CaO-MgO-Al2O3-SiO2 slag with low silica were measured by the Archimedean method in a wide temperature range from 1773 to 1 873 K. Nine different slag compositions were chosen b...The densities of the selected quaternary CaO-MgO-Al2O3-SiO2 slag with low silica were measured by the Archimedean method in a wide temperature range from 1773 to 1 873 K. Nine different slag compositions were chosen based on three diffel：ent levels of CaO content and three different levels of SiO2 content. WM,O was equal to 7. 0%. Wcao were varied from 40.04% to 50.64%, for wsO2 =10.25%-20. 70%. The effects of temperature, SiOz content and optical basicity were studied. It is shown that density decreases approximately linearly with an increase in temperature. Under the same CaO content, the density decreases with increasing of SiOz content, and increases with optical basicity increasing. Based on the experimental data as the boundary of the homogenous phase region predicated by FACTSAGE software, the mass triangle model is used to calculate the density of selected limited homogenous phase region. The results showed that the mass triangle model works well.展开更多
A novel series of β-propanamide derivatives as inhibitors of cholesteryl ester transfer protein（CETP）were synthesized.Previously,H3（IC_（50） 2 μmol/L） was observed to inhibit CETP moderately（Xie et ah,2016）.S...A novel series of β-propanamide derivatives as inhibitors of cholesteryl ester transfer protein（CETP）were synthesized.Previously,H3（IC_（50） 2 μmol/L） was observed to inhibit CETP moderately（Xie et ah,2016）.Structural modifications based on H3 led to discovery of the successful CETP inhibitor,known as 1-methyl-4-arylpyrazole.Using a similar approach,compound Q08 was identified as a highly potent CETP inhibitor with an IC_（50） of 490 nmol/L in vitro.展开更多
基金Item Sponsored by National Natural Science Foundation of China(50874072)Program for Changjiang Scholars and Innovative Research Team in University of China(IRT0739)
文摘The densities of the selected quaternary CaO-MgO-Al2O3-SiO2 slag with low silica were measured by the Archimedean method in a wide temperature range from 1773 to 1 873 K. Nine different slag compositions were chosen based on three diffel：ent levels of CaO content and three different levels of SiO2 content. WM,O was equal to 7. 0%. Wcao were varied from 40.04% to 50.64%, for wsO2 =10.25%-20. 70%. The effects of temperature, SiOz content and optical basicity were studied. It is shown that density decreases approximately linearly with an increase in temperature. Under the same CaO content, the density decreases with increasing of SiOz content, and increases with optical basicity increasing. Based on the experimental data as the boundary of the homogenous phase region predicated by FACTSAGE software, the mass triangle model is used to calculate the density of selected limited homogenous phase region. The results showed that the mass triangle model works well.
基金supported by the National Natural Science Foundation of China (No. 81373324)the program for Innovative Research Team of the Ministry of Education and Program for Liaoning Innovative Research Team in University
文摘A novel series of β-propanamide derivatives as inhibitors of cholesteryl ester transfer protein（CETP）were synthesized.Previously,H3（IC_（50） 2 μmol/L） was observed to inhibit CETP moderately（Xie et ah,2016）.Structural modifications based on H3 led to discovery of the successful CETP inhibitor,known as 1-methyl-4-arylpyrazole.Using a similar approach,compound Q08 was identified as a highly potent CETP inhibitor with an IC_（50） of 490 nmol/L in vitro.
